Gut mycobiome and its interaction with diet, gut bacteria and alzheimer's disease markers in subjects with mild cognitive impairment: A pilot study

Recently, we reported that patients with mild cognitive impairment (MCI) harbor specific signature of bacteria in their gut and that a modified Mediterranean ketogenic diet (MMKD) improves Alzheimer's disease (AD) markers in cerebrospinal fluid (CSF) and the signatures of gut bacteria. However,...

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Bibliographic Details
Published in:	EBioMedicine Vol. 59; p. 102950
Main Authors:	Nagpal, Ravinder, Neth, Bryan J., Wang, Shaohua, Mishra, Sidharth P., Craft, Suzanne, Yadav, Hariom
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.09.2020 Elsevier
Subjects:	Advanced Basic Science Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - psychology Alzheimer's amyloid peptides Apolipoprotein E4 - genetics Bacteria Biomarkers Cognitive Dysfunction Computational Biology - methods Dementia Diet Diet, Ketogenic Feces - microbiology Female Fungi Gastrointestinal Microbiome Genotype Humans Internal Medicine Ketogenic diet Male Mediterranean diet Metagenome Metagenomics - methods Microbiome Mycobiota Nutrition Pilot Projects Research paper Short-chain fatty acids tau PCoA ApoE ε−4 LP OTUs LDA ITS LPS Fungi AHAD CSF KD MMKD Alzheimer's Short-chain fatty acids AD Nutrition Mediterranean diet tau CN Ketogenic diet LEfSe Mycobiota MCI SCFAs amyloid peptides Aß Dementia Microbiome Alzheimer disease internal transcribed spacer principal coordinate analysis American Heart Association Diet modified Mediterranean-ketogenic diet lumbar puncture linear discrimination analysis apolipoprotein-E ε−4 allele linear discrimination analysis effect size amyloid beta cerebrospinal fluid operational taxonomic units cognitively normal lipopolysaccharide mildly cognitive impairment
ISSN:	2352-3964, 2352-3964
Online Access:	Get full text
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