Non-coding RNAs in depression: Promising diagnostic and therapeutic biomarkers

Non-coding RNAs (ncRNAs), including microRNAs, circular RNAs, and long non-coding RNAs, are important regulators of normal biological processes and their abnormal expression may be involved in the pathogenesis of human diseases including depression. Multiple studies have demonstrated a significantly...

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Vydáno v:EBioMedicine Ročník 71; s. 103569
Hlavní autoři: Shi, Yachen, Wang, Qingyun, Song, Ruize, Kong, Yan, Zhang, Zhijun
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 01.09.2021
Elsevier
Témata:
Advanced Basic Science
Animals
Biomarker
Biomarkers
Cell-Free Nucleic Acids
Circular RNAs
Depression
Depression - diagnosis
Depression - etiology
Depression - metabolism
Depression - therapy
Disease Susceptibility
Drug Development
Gene Expression Regulation
Gene Regulatory Networks
Humans
Internal Medicine
Long non-coding RNAs
MicroRNAs
MicroRNAs - genetics
Molecular Diagnostic Techniques
Molecular Targeted Therapy
Non-coding RNAs
Prognosis
Review
RNA Interference
RNA, Circular
RNA, Long Noncoding
Non-coding RNAs
Depression
Long non-coding RNAs
Biomarker
MicroRNAs
Circular RNAs
ISSN:2352-3964, 2352-3964
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Shrnutí:Non-coding RNAs (ncRNAs), including microRNAs, circular RNAs, and long non-coding RNAs, are important regulators of normal biological processes and their abnormal expression may be involved in the pathogenesis of human diseases including depression. Multiple studies have demonstrated a significantly increased or reduced ncRNAs expression in depressed patients compared with healthy subjects and that antidepressant therapy can alter the aberrant expression of ncRNAs in depressed patients. Although the existing evidence is important, it is also mixed and a comprehensive review to guide an effective clinical translation is lacking. Focused on human research, this review summarizes clinical findings of ncRNAs in depression, including those in brain tissues and peripheral samples. We outlined the characteristics and functions of ncRNAs and highlighted their performance in the diagnosis and treatment of depression. Although their precise roles in depression remain uncertain, ncRNAs have shown potential value as biomarkers for diagnosis and therapy in depressed patients.
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ISSN:2352-3964
2352-3964
DOI:10.1016/j.ebiom.2021.103569