Extrapulmonary manifestations of COVID-19

Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal s...

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Vydáno v:Nature medicine Ročník 26; číslo 7; s. 1017 - 1032
Hlavní autoři: Gupta, Aakriti, Madhavan, Mahesh V., Sehgal, Kartik, Nair, Nandini, Mahajan, Shiwani, Sehrawat, Tejasav S., Bikdeli, Behnood, Ahluwalia, Neha, Ausiello, John C., Wan, Elaine Y., Freedberg, Daniel E., Kirtane, Ajay J., Parikh, Sahil A., Maurer, Mathew S., Nordvig, Anna S., Accili, Domenico, Bathon, Joan M., Mohan, Sumit, Bauer, Kenneth A., Leon, Martin B., Krumholz, Harlan M., Uriel, Nir, Mehra, Mandeep R., Elkind, Mitchell S. V., Stone, Gregg W., Schwartz, Allan, Ho, David D., Bilezikian, John P., Landry, Donald W.
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Nature Publishing Group US 01.07.2020
Nature Publishing Group
Témata:
692/420/254
692/699/255/2514
ACE2
Adaptive Immunity - physiology
Angiotensin-converting enzyme 2
Arrhythmia
Betacoronavirus - pathogenicity
Betacoronavirus - physiology
Biomedical and Life Sciences
Biomedicine
Cancer Research
Coronavirus Infections - diagnosis
Coronavirus Infections - immunology
Coronavirus Infections - pathology
Coronavirus Infections - therapy
Coronaviruses
COVID-19
Damage
Disease Progression
Endothelium, Vascular - pathology
Endothelium, Vascular - virology
Gastrointestinal symptoms
Humans
Hyperglycemia
Immune response
Infectious Diseases
Inflammation - etiology
Inflammation - pathology
Inflammation - virology
Injuries
Ketosis
Metabolic Diseases
Molecular Medicine
Neurosciences
Organ Specificity
Pandemics
Pathophysiology
Pneumonia, Viral - diagnosis
Pneumonia, Viral - immunology
Pneumonia, Viral - pathology
Pneumonia, Viral - therapy
Renin-Angiotensin System - physiology
Respiratory diseases
Respiratory pathology
Review Article
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Thrombosis - etiology
Thrombosis - pathology
Thrombosis - virology
Viral diseases
Virus Internalization
United States
ISSN:1078-8956, 1546-170X, 1546-170X
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Shrnutí:Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications. Given that ACE2, the entry receptor for the causative coronavirus SARS-CoV-2, is expressed in multiple extrapulmonary tissues, direct viral tissue damage is a plausible mechanism of injury. In addition, endothelial damage and thromboinflammation, dysregulation of immune responses, and maladaptation of ACE2-related pathways might all contribute to these extrapulmonary manifestations of COVID-19. Here we review the extrapulmonary organ-specific pathophysiology, presentations and management considerations for patients with COVID-19 to aid clinicians and scientists in recognizing and monitoring the spectrum of manifestations, and in developing research priorities and therapeutic strategies for all organ systems involved. Recent clinical observations have prompted clinicians to think of COVID-19 as being more than a respiratory disease.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1078-8956
1546-170X
1546-170X
DOI:10.1038/s41591-020-0968-3