Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer

Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate a hypoxia-related mRNA signature for localized prostate cancer. Hypoxia genes were identified in vitro via RNA-sequencing and combined with in vivo gene co-expression analysis to generate a signatu...

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Bibliographic Details
Published in:	EBioMedicine Vol. 31; pp. 182 - 189
Main Authors:	Yang, Lingjian, Roberts, Darren, Takhar, Mandeep, Erho, Nicholas, Bibby, Becky A.S., Thiruthaneeswaran, Niluja, Bhandari, Vinayak, Cheng, Wei-Chen, Haider, Syed, McCorry, Amy M.B., McArt, Darragh, Jain, Suneil, Alshalalfa, Mohammed, Ross, Ashley, Schaffer, Edward, Den, Robert B., Jeffrey Karnes, R., Klein, Eric, Hoskin, Peter J., Freedland, Stephen J., Lamb, Alastair D., Neal, David E., Buffa, Francesca M., Bristow, Robert G., Boutros, Paul C., Davicioni, Elai, Choudhury, Ananya, West, Catharine M.L.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.05.2018 Elsevier
Subjects:	Advanced Basic Science Disease-Free Survival Gene Expression Regulation, Neoplastic Gene expression signature Humans Hypoxia Internal Medicine Male Neoplasm Metastasis Prognostic biomarker Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - mortality Prostatic Neoplasms - therapy Radiotherapy Research Paper Survival Rate Tumor Hypoxia - genetics Hypoxia Radiotherapy Gene expression signature Prostate cancer Prognostic biomarker
ISSN:	2352-3964, 2352-3964
Online Access:	Get full text
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