The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study
Since a national lockdown was introduced across the UK in March, 2020, in response to the COVID-19 pandemic, cancer screening has been suspended, routine diagnostic work deferred, and only urgent symptomatic cases prioritised for diagnostic intervention. In this study, we estimated the impact of del...
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| Vydané v: | The lancet oncology Ročník 21; číslo 8; s. 1023 - 1034 |
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| Hlavní autori: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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England
Elsevier Ltd
01.08.2020
Elsevier Limited The Author(s). Published by Elsevier Ltd |
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| ISSN: | 1470-2045, 1474-5488, 1474-5488 |
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| Abstract | Since a national lockdown was introduced across the UK in March, 2020, in response to the COVID-19 pandemic, cancer screening has been suspended, routine diagnostic work deferred, and only urgent symptomatic cases prioritised for diagnostic intervention. In this study, we estimated the impact of delays in diagnosis on cancer survival outcomes in four major tumour types.
In this national population-based modelling study, we used linked English National Health Service (NHS) cancer registration and hospital administrative datasets for patients aged 15–84 years, diagnosed with breast, colorectal, and oesophageal cancer between Jan 1, 2010, and Dec 31, 2010, with follow-up data until Dec 31, 2014, and diagnosed with lung cancer between Jan 1, 2012, and Dec 31, 2012, with follow-up data until Dec 31, 2015. We use a routes-to-diagnosis framework to estimate the impact of diagnostic delays over a 12-month period from the commencement of physical distancing measures, on March 16, 2020, up to 1, 3, and 5 years after diagnosis. To model the subsequent impact of diagnostic delays on survival, we reallocated patients who were on screening and routine referral pathways to urgent and emergency pathways that are associated with more advanced stage of disease at diagnosis. We considered three reallocation scenarios representing the best to worst case scenarios and reflect actual changes in the diagnostic pathway being seen in the NHS, as of March 16, 2020, and estimated the impact on net survival at 1, 3, and 5 years after diagnosis to calculate the additional deaths that can be attributed to cancer, and the total years of life lost (YLLs) compared with pre-pandemic data.
We collected data for 32 583 patients with breast cancer, 24 975 with colorectal cancer, 6744 with oesophageal cancer, and 29 305 with lung cancer. Across the three different scenarios, compared with pre-pandemic figures, we estimate a 7·9–9·6% increase in the number of deaths due to breast cancer up to year 5 after diagnosis, corresponding to between 281 (95% CI 266–295) and 344 (329–358) additional deaths. For colorectal cancer, we estimate 1445 (1392–1591) to 1563 (1534–1592) additional deaths, a 15·3–16·6% increase; for lung cancer, 1235 (1220–1254) to 1372 (1343–1401) additional deaths, a 4·8–5·3% increase; and for oesophageal cancer, 330 (324–335) to 342 (336–348) additional deaths, 5·8–6·0% increase up to 5 years after diagnosis. For these four tumour types, these data correspond with 3291–3621 additional deaths across the scenarios within 5 years. The total additional YLLs across these cancers is estimated to be 59 204–63 229 years.
Substantial increases in the number of avoidable cancer deaths in England are to be expected as a result of diagnostic delays due to the COVID-19 pandemic in the UK. Urgent policy interventions are necessary, particularly the need to manage the backlog within routine diagnostic services to mitigate the expected impact of the COVID-19 pandemic on patients with cancer.
UK Research and Innovation Economic and Social Research Council. |
|---|---|
| AbstractList | Since a national lockdown was introduced across the UK in March, 2020, in response to the COVID-19 pandemic, cancer screening has been suspended, routine diagnostic work deferred, and only urgent symptomatic cases prioritised for diagnostic intervention. In this study, we estimated the impact of delays in diagnosis on cancer survival outcomes in four major tumour types.
In this national population-based modelling study, we used linked English National Health Service (NHS) cancer registration and hospital administrative datasets for patients aged 15-84 years, diagnosed with breast, colorectal, and oesophageal cancer between Jan 1, 2010, and Dec 31, 2010, with follow-up data until Dec 31, 2014, and diagnosed with lung cancer between Jan 1, 2012, and Dec 31, 2012, with follow-up data until Dec 31, 2015. We use a routes-to-diagnosis framework to estimate the impact of diagnostic delays over a 12-month period from the commencement of physical distancing measures, on March 16, 2020, up to 1, 3, and 5 years after diagnosis. To model the subsequent impact of diagnostic delays on survival, we reallocated patients who were on screening and routine referral pathways to urgent and emergency pathways that are associated with more advanced stage of disease at diagnosis. We considered three reallocation scenarios representing the best to worst case scenarios and reflect actual changes in the diagnostic pathway being seen in the NHS, as of March 16, 2020, and estimated the impact on net survival at 1, 3, and 5 years after diagnosis to calculate the additional deaths that can be attributed to cancer, and the total years of life lost (YLLs) compared with pre-pandemic data.
We collected data for 32 583 patients with breast cancer, 24 975 with colorectal cancer, 6744 with oesophageal cancer, and 29 305 with lung cancer. Across the three different scenarios, compared with pre-pandemic figures, we estimate a 7·9-9·6% increase in the number of deaths due to breast cancer up to year 5 after diagnosis, corresponding to between 281 (95% CI 266-295) and 344 (329-358) additional deaths. For colorectal cancer, we estimate 1445 (1392-1591) to 1563 (1534-1592) additional deaths, a 15·3-16·6% increase; for lung cancer, 1235 (1220-1254) to 1372 (1343-1401) additional deaths, a 4·8-5·3% increase; and for oesophageal cancer, 330 (324-335) to 342 (336-348) additional deaths, 5·8-6·0% increase up to 5 years after diagnosis. For these four tumour types, these data correspond with 3291-3621 additional deaths across the scenarios within 5 years. The total additional YLLs across these cancers is estimated to be 59 204-63 229 years.
Substantial increases in the number of avoidable cancer deaths in England are to be expected as a result of diagnostic delays due to the COVID-19 pandemic in the UK. Urgent policy interventions are necessary, particularly the need to manage the backlog within routine diagnostic services to mitigate the expected impact of the COVID-19 pandemic on patients with cancer.
UK Research and Innovation Economic and Social Research Council. SummaryBackgroundSince a national lockdown was introduced across the UK in March, 2020, in response to the COVID-19 pandemic, cancer screening has been suspended, routine diagnostic work deferred, and only urgent symptomatic cases prioritised for diagnostic intervention. In this study, we estimated the impact of delays in diagnosis on cancer survival outcomes in four major tumour types. MethodsIn this national population-based modelling study, we used linked English National Health Service (NHS) cancer registration and hospital administrative datasets for patients aged 15–84 years, diagnosed with breast, colorectal, and oesophageal cancer between Jan 1, 2010, and Dec 31, 2010, with follow-up data until Dec 31, 2014, and diagnosed with lung cancer between Jan 1, 2012, and Dec 31, 2012, with follow-up data until Dec 31, 2015. We use a routes-to-diagnosis framework to estimate the impact of diagnostic delays over a 12-month period from the commencement of physical distancing measures, on March 16, 2020, up to 1, 3, and 5 years after diagnosis. To model the subsequent impact of diagnostic delays on survival, we reallocated patients who were on screening and routine referral pathways to urgent and emergency pathways that are associated with more advanced stage of disease at diagnosis. We considered three reallocation scenarios representing the best to worst case scenarios and reflect actual changes in the diagnostic pathway being seen in the NHS, as of March 16, 2020, and estimated the impact on net survival at 1, 3, and 5 years after diagnosis to calculate the additional deaths that can be attributed to cancer, and the total years of life lost (YLLs) compared with pre-pandemic data. FindingsWe collected data for 32 583 patients with breast cancer, 24 975 with colorectal cancer, 6744 with oesophageal cancer, and 29 305 with lung cancer. Across the three different scenarios, compared with pre-pandemic figures, we estimate a 7·9–9·6% increase in the number of deaths due to breast cancer up to year 5 after diagnosis, corresponding to between 281 (95% CI 266–295) and 344 (329–358) additional deaths. For colorectal cancer, we estimate 1445 (1392–1591) to 1563 (1534–1592) additional deaths, a 15·3–16·6% increase; for lung cancer, 1235 (1220–1254) to 1372 (1343–1401) additional deaths, a 4·8–5·3% increase; and for oesophageal cancer, 330 (324–335) to 342 (336–348) additional deaths, 5·8–6·0% increase up to 5 years after diagnosis. For these four tumour types, these data correspond with 3291–3621 additional deaths across the scenarios within 5 years. The total additional YLLs across these cancers is estimated to be 59 204–63 229 years. InterpretationSubstantial increases in the number of avoidable cancer deaths in England are to be expected as a result of diagnostic delays due to the COVID-19 pandemic in the UK. Urgent policy interventions are necessary, particularly the need to manage the backlog within routine diagnostic services to mitigate the expected impact of the COVID-19 pandemic on patients with cancer. FundingUK Research and Innovation Economic and Social Research Council. Since a national lockdown was introduced across the UK in March, 2020, in response to the COVID-19 pandemic, cancer screening has been suspended, routine diagnostic work deferred, and only urgent symptomatic cases prioritised for diagnostic intervention. In this study, we estimated the impact of delays in diagnosis on cancer survival outcomes in four major tumour types.BACKGROUNDSince a national lockdown was introduced across the UK in March, 2020, in response to the COVID-19 pandemic, cancer screening has been suspended, routine diagnostic work deferred, and only urgent symptomatic cases prioritised for diagnostic intervention. In this study, we estimated the impact of delays in diagnosis on cancer survival outcomes in four major tumour types.In this national population-based modelling study, we used linked English National Health Service (NHS) cancer registration and hospital administrative datasets for patients aged 15-84 years, diagnosed with breast, colorectal, and oesophageal cancer between Jan 1, 2010, and Dec 31, 2010, with follow-up data until Dec 31, 2014, and diagnosed with lung cancer between Jan 1, 2012, and Dec 31, 2012, with follow-up data until Dec 31, 2015. We use a routes-to-diagnosis framework to estimate the impact of diagnostic delays over a 12-month period from the commencement of physical distancing measures, on March 16, 2020, up to 1, 3, and 5 years after diagnosis. To model the subsequent impact of diagnostic delays on survival, we reallocated patients who were on screening and routine referral pathways to urgent and emergency pathways that are associated with more advanced stage of disease at diagnosis. We considered three reallocation scenarios representing the best to worst case scenarios and reflect actual changes in the diagnostic pathway being seen in the NHS, as of March 16, 2020, and estimated the impact on net survival at 1, 3, and 5 years after diagnosis to calculate the additional deaths that can be attributed to cancer, and the total years of life lost (YLLs) compared with pre-pandemic data.METHODSIn this national population-based modelling study, we used linked English National Health Service (NHS) cancer registration and hospital administrative datasets for patients aged 15-84 years, diagnosed with breast, colorectal, and oesophageal cancer between Jan 1, 2010, and Dec 31, 2010, with follow-up data until Dec 31, 2014, and diagnosed with lung cancer between Jan 1, 2012, and Dec 31, 2012, with follow-up data until Dec 31, 2015. We use a routes-to-diagnosis framework to estimate the impact of diagnostic delays over a 12-month period from the commencement of physical distancing measures, on March 16, 2020, up to 1, 3, and 5 years after diagnosis. To model the subsequent impact of diagnostic delays on survival, we reallocated patients who were on screening and routine referral pathways to urgent and emergency pathways that are associated with more advanced stage of disease at diagnosis. We considered three reallocation scenarios representing the best to worst case scenarios and reflect actual changes in the diagnostic pathway being seen in the NHS, as of March 16, 2020, and estimated the impact on net survival at 1, 3, and 5 years after diagnosis to calculate the additional deaths that can be attributed to cancer, and the total years of life lost (YLLs) compared with pre-pandemic data.We collected data for 32 583 patients with breast cancer, 24 975 with colorectal cancer, 6744 with oesophageal cancer, and 29 305 with lung cancer. Across the three different scenarios, compared with pre-pandemic figures, we estimate a 7·9-9·6% increase in the number of deaths due to breast cancer up to year 5 after diagnosis, corresponding to between 281 (95% CI 266-295) and 344 (329-358) additional deaths. For colorectal cancer, we estimate 1445 (1392-1591) to 1563 (1534-1592) additional deaths, a 15·3-16·6% increase; for lung cancer, 1235 (1220-1254) to 1372 (1343-1401) additional deaths, a 4·8-5·3% increase; and for oesophageal cancer, 330 (324-335) to 342 (336-348) additional deaths, 5·8-6·0% increase up to 5 years after diagnosis. For these four tumour types, these data correspond with 3291-3621 additional deaths across the scenarios within 5 years. The total additional YLLs across these cancers is estimated to be 59 204-63 229 years.FINDINGSWe collected data for 32 583 patients with breast cancer, 24 975 with colorectal cancer, 6744 with oesophageal cancer, and 29 305 with lung cancer. Across the three different scenarios, compared with pre-pandemic figures, we estimate a 7·9-9·6% increase in the number of deaths due to breast cancer up to year 5 after diagnosis, corresponding to between 281 (95% CI 266-295) and 344 (329-358) additional deaths. For colorectal cancer, we estimate 1445 (1392-1591) to 1563 (1534-1592) additional deaths, a 15·3-16·6% increase; for lung cancer, 1235 (1220-1254) to 1372 (1343-1401) additional deaths, a 4·8-5·3% increase; and for oesophageal cancer, 330 (324-335) to 342 (336-348) additional deaths, 5·8-6·0% increase up to 5 years after diagnosis. For these four tumour types, these data correspond with 3291-3621 additional deaths across the scenarios within 5 years. The total additional YLLs across these cancers is estimated to be 59 204-63 229 years.Substantial increases in the number of avoidable cancer deaths in England are to be expected as a result of diagnostic delays due to the COVID-19 pandemic in the UK. Urgent policy interventions are necessary, particularly the need to manage the backlog within routine diagnostic services to mitigate the expected impact of the COVID-19 pandemic on patients with cancer.INTERPRETATIONSubstantial increases in the number of avoidable cancer deaths in England are to be expected as a result of diagnostic delays due to the COVID-19 pandemic in the UK. Urgent policy interventions are necessary, particularly the need to manage the backlog within routine diagnostic services to mitigate the expected impact of the COVID-19 pandemic on patients with cancer.UK Research and Innovation Economic and Social Research Council.FUNDINGUK Research and Innovation Economic and Social Research Council. Summary Background Since a national lockdown was introduced across the UK in March, 2020, in response to the COVID-19 pandemic, cancer screening has been suspended, routine diagnostic work deferred, and only urgent symptomatic cases prioritised for diagnostic intervention. In this study, we estimated the impact of delays in diagnosis on cancer survival outcomes in four major tumour types. Methods In this national population-based modelling study, we used linked English National Health Service (NHS) cancer registration and hospital administrative datasets for patients aged 15–84 years, diagnosed with breast, colorectal, and oesophageal cancer between Jan 1, 2010, and Dec 31, 2010, with follow-up data until Dec 31, 2014, and diagnosed with lung cancer between Jan 1, 2012, and Dec 31, 2012, with follow-up data until Dec 31, 2015. We use a routes-to-diagnosis framework to estimate the impact of diagnostic delays over a 12-month period from the commencement of physical distancing measures, on March 16, 2020, up to 1, 3, and 5 years after diagnosis. To model the subsequent impact of diagnostic delays on survival, we reallocated patients who were on screening and routine referral pathways to urgent and emergency pathways that are associated with more advanced stage of disease at diagnosis. We considered three reallocation scenarios representing the best to worst case scenarios and reflect actual changes in the diagnostic pathway being seen in the NHS, as of March 16, 2020, and estimated the impact on net survival at 1, 3, and 5 years after diagnosis to calculate the additional deaths that can be attributed to cancer, and the total years of life lost (YLLs) compared with pre-pandemic data. Findings We collected data for 32 583 patients with breast cancer, 24 975 with colorectal cancer, 6744 with oesophageal cancer, and 29 305 with lung cancer. Across the three different scenarios, compared with pre-pandemic figures, we estimate a 7·9–9·6% increase in the number of deaths due to breast cancer up to year 5 after diagnosis, corresponding to between 281 (95% CI 266–295) and 344 (329–358) additional deaths. For colorectal cancer, we estimate 1445 (1392–1591) to 1563 (1534–1592) additional deaths, a 15·3–16·6% increase; for lung cancer, 1235 (1220–1254) to 1372 (1343–1401) additional deaths, a 4·8–5·3% increase; and for oesophageal cancer, 330 (324–335) to 342 (336–348) additional deaths, 5·8–6·0% increase up to 5 years after diagnosis. For these four tumour types, these data correspond with 3291–3621 additional deaths across the scenarios within 5 years. The total additional YLLs across these cancers is estimated to be 59 204–63 229 years. Interpretation Substantial increases in the number of avoidable cancer deaths in England are to be expected as a result of diagnostic delays due to the COVID-19 pandemic in the UK. Urgent policy interventions are necessary, particularly the need to manage the backlog within routine diagnostic services to mitigate the expected impact of the COVID-19 pandemic on patients with cancer. Funding UK Research and Innovation Economic and Social Research Council. |
| Author | Aggarwal, Ajay Nolte, Ellen Spicer, James Morris, Melanie Purushotham, Arnie Sullivan, Richard Rachet, Bernard Maringe, Camille |
| Author_xml | – sequence: 1 givenname: Camille surname: Maringe fullname: Maringe, Camille organization: Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK – sequence: 2 givenname: James surname: Spicer fullname: Spicer, James organization: School of Cancer and Pharmaceutical Sciences, King's College London, London, UK – sequence: 3 givenname: Melanie surname: Morris fullname: Morris, Melanie organization: Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK – sequence: 4 givenname: Arnie surname: Purushotham fullname: Purushotham, Arnie organization: School of Cancer and Pharmaceutical Sciences, King's College London, London, UK – sequence: 5 givenname: Ellen surname: Nolte fullname: Nolte, Ellen organization: Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK – sequence: 6 givenname: Richard surname: Sullivan fullname: Sullivan, Richard organization: School of Cancer and Pharmaceutical Sciences, King's College London, London, UK – sequence: 7 givenname: Bernard surname: Rachet fullname: Rachet, Bernard organization: Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK – sequence: 8 givenname: Ajay surname: Aggarwal fullname: Aggarwal, Ajay email: ajay.aggarwal@lshtm.ac.uk organization: Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32702310$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S1470-2045(20)30242-4 10.1016/j.annonc.2020.05.009 10.1038/bjc.2017.236 10.1016/j.clon.2020.03.006 10.1371/journal.pone.0126608 10.3109/02688697.2015.1012050 10.1038/bjc.2013.177 10.1371/journal.pone.0172814 10.1038/sj.bjc.6605384 10.1038/bjc.2012.408 10.1016/S0140-6736(20)30985-5 10.1056/NEJMp2007637 10.1136/bmjgast-2019-000293 10.1016/j.canep.2011.09.007 10.1038/s43018-020-0074-y 10.1038/bjc.2015.48 10.1186/s12885-016-2967-9 10.1007/s11605-009-1109-y 10.1053/j.gastro.2018.07.037 |
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| References | (bib37) Aug 12, 2019 Noble, McLennan, Wilkinson (bib16) 2008 Sud, Jones, Broggio (bib22) 2020 (bib9) July 26, 2017 Elliss-Brookes, McPhail, Ives (bib13) 2012; 107 (bib5) March 20, 2020 (bib1) 2020 Neal (bib33) 2009; 101 Studdert, Hall (bib30) 2020 Morris (bib25) June 18, 2020 Roberts (bib35) June 1, 2020 Mason, Proctor (bib11) April 22, 2020 (bib24) 2020 Marmot, Altman, Cameron, Dewar, Thompson, Wilcox (bib18) 2013; 108 Richards, Anderson, Carter, Ebert, Mossialos (bib23) 2020; 1 Grotenhuis, van Hagen, Wijnhoven, Spaander, Tilanus, van Lanschot (bib32) 2010; 14 Tørring, Murchie, Hamilton (bib40) 2017; 117 Tørring, Murchie, Esteva (bib3) 2015; 24 (bib14) July 3, 2019 Coles, Aristei, Bliss (bib6) 2020; 32 (bib38) 2018 Neal, Tharmanathan, France (bib2) 2015; 112 Maringe, Fowler, Rachet, Luque-Fernandez (bib15) 2017; 12 Jones, Neal, Duffy, Scott, Whitaker, Brain (bib12) 2020; 21 Altmann, Douek, Boyton (bib27) 2020; 395 (bib8) April 3, 2020 (bib4) April 7, 2020 Penman, Rees (bib36) June 30, 2020 (bib28) April 27, 2020 Illman (bib26) April 5, 2020 Kalager, Wieszczy, Lansdorp-Vogelaar, Corley, Bretthauer, Kaminski (bib39) 2018; 155 Redaniel, Martin, Ridd, Wade, Jeffreys (bib31) 2015; 10 Aggarwal, Herz, Campbell, Arkush, Short, Rees (bib34) 2015; 29 Bodkin (bib10) April 15, 2020 (bib7) 2020 (bib17) 2019 Pohar Perme, Estève, Rachet (bib19) 2016; 16 Hinchliffe, Dickman, Lambert (bib21) 2012; 36 Mowat, Digby, Strachan (bib29) 2019; 6 Ederer, Axtell, Cutler (bib20) 1961; 6 Studdert (10.1016/S1470-2045(20)30388-0_bib30) 2020 Grotenhuis (10.1016/S1470-2045(20)30388-0_bib32) 2010; 14 (10.1016/S1470-2045(20)30388-0_bib4) 2020 Redaniel (10.1016/S1470-2045(20)30388-0_bib31) 2015; 10 Aggarwal (10.1016/S1470-2045(20)30388-0_bib34) 2015; 29 Coles (10.1016/S1470-2045(20)30388-0_bib6) 2020; 32 Illman (10.1016/S1470-2045(20)30388-0_bib26) 2020 (10.1016/S1470-2045(20)30388-0_bib14) 2019 Richards (10.1016/S1470-2045(20)30388-0_bib23) 2020; 1 Marmot (10.1016/S1470-2045(20)30388-0_bib18) 2013; 108 (10.1016/S1470-2045(20)30388-0_bib7) 2020 Elliss-Brookes (10.1016/S1470-2045(20)30388-0_bib13) 2012; 107 Maringe (10.1016/S1470-2045(20)30388-0_bib15) 2017; 12 Hinchliffe (10.1016/S1470-2045(20)30388-0_bib21) 2012; 36 (10.1016/S1470-2045(20)30388-0_bib9) 2017 Tørring (10.1016/S1470-2045(20)30388-0_bib3) 2015; 24 (10.1016/S1470-2045(20)30388-0_bib17) 2019 Pohar Perme (10.1016/S1470-2045(20)30388-0_bib19) 2016; 16 Altmann (10.1016/S1470-2045(20)30388-0_bib27) 2020; 395 Noble (10.1016/S1470-2045(20)30388-0_bib16) 2008 (10.1016/S1470-2045(20)30388-0_bib37) 2019 Neal (10.1016/S1470-2045(20)30388-0_bib2) 2015; 112 Penman (10.1016/S1470-2045(20)30388-0_bib36) Ederer (10.1016/S1470-2045(20)30388-0_bib20) 1961; 6 (10.1016/S1470-2045(20)30388-0_bib38) 2018 Roberts (10.1016/S1470-2045(20)30388-0_bib35) 2020 Mason (10.1016/S1470-2045(20)30388-0_bib11) 2020 Tørring (10.1016/S1470-2045(20)30388-0_bib40) 2017; 117 (10.1016/S1470-2045(20)30388-0_bib5) 2020 Morris (10.1016/S1470-2045(20)30388-0_bib25) 2020 Sud (10.1016/S1470-2045(20)30388-0_bib22) 2020 Bodkin (10.1016/S1470-2045(20)30388-0_bib10) 2020 (10.1016/S1470-2045(20)30388-0_bib8) 2020 Neal (10.1016/S1470-2045(20)30388-0_bib33) 2009; 101 Mowat (10.1016/S1470-2045(20)30388-0_bib29) 2019; 6 Kalager (10.1016/S1470-2045(20)30388-0_bib39) 2018; 155 Jones (10.1016/S1470-2045(20)30388-0_bib12) 2020; 21 (10.1016/S1470-2045(20)30388-0_bib24) 2020 32702312 - Lancet Oncol. 2020 Aug;21(8):1000-1002. doi: 10.1016/S1470-2045(20)30391-0. 34049776 - Eur J Cancer. 2021 Jul;152:233-242. doi: 10.1016/j.ejca.2021.04.019. 33387506 - Lancet Oncol. 2021 Jan;22(1):e5. doi: 10.1016/S1470-2045(20)30752-X. 33778775 - Lancet Rheumatol. 2021 Feb;3(2):e83. doi: 10.1016/S2665-9913(21)00001-1. 33053379 - Radiother Oncol. 2021 Feb;155:1-2. doi: 10.1016/j.radonc.2020.09.055. |
| References_xml | – volume: 107 start-page: 1220 year: 2012 end-page: 1226 ident: bib13 article-title: Routes to diagnosis for cancer - determining the patient journey using multiple routine data sets publication-title: Br J Cancer – year: 2008 ident: bib16 article-title: The English Indices of Deprivation 2007 – volume: 36 start-page: 148 year: 2012 end-page: 152 ident: bib21 article-title: Adjusting for the proportion of cancer deaths in the general population when using relative survival: a sensitivity analysis publication-title: Cancer Epidemiol – volume: 395 start-page: 1527 year: 2020 end-page: 1529 ident: bib27 article-title: What policy makers need to know about COVID-19 protective immunity publication-title: Lancet – year: April 7, 2020 ident: bib4 article-title: Publication approval reference 001559. Specialty guides for patient management during the coronavirus pandemic. Clinical guide for the management of essential cancer surgery for adults during the coronavirus pandemic – volume: 32 start-page: 279 year: 2020 end-page: 281 ident: bib6 article-title: Guidelines on radiation therapy for breast cancer during the COVID-19 pandemic publication-title: Clin Oncol – year: 2018 ident: bib38 article-title: Annual report 2018. 2018 – volume: 155 start-page: 592 year: 2018 end-page: 595 ident: bib39 article-title: Overdiagnosis in colorectal cancer screening: time to acknowledge a blind spot publication-title: Gastroenterology – year: 2019 ident: bib17 article-title: Cancer registration statistics, England Statistical bulletins – volume: 24 start-page: 22 year: 2015 ident: bib3 article-title: The signal and the noise in colorectal cancer diagnosis: exploring and explaining the relationship between diagnostic delays and stage at diagnosis using the Ca-PRI Colorectal Cancer Collaboration dataset publication-title: Eur J Cancer Care – volume: 1 start-page: 565 year: 2020 end-page: 567 ident: bib23 article-title: The impact of the COVID-19 pandemic on cancer care publication-title: Nature Cancer – year: 2020 ident: bib7 article-title: Coronavirus (COVID-19): cancer treatment documents – year: June 1, 2020 ident: bib35 article-title: Over 2 million people waiting for cancer screening, tests and treatments – volume: 14 start-page: 476 year: 2010 end-page: 483 ident: bib32 article-title: Delay in diagnostic workup and treatment of esophageal cancer publication-title: J Gastrointest Surg – volume: 108 start-page: 2205 year: 2013 end-page: 2240 ident: bib18 article-title: The benefits and harms of breast cancer screening: an independent review publication-title: Br J Cancer – year: 2020 ident: bib24 article-title: Resuming bowel cancer screening post-COVID-19 publication-title: Lancet Gastroenterol Hepatol – volume: 112 start-page: S92 year: 2015 end-page: S107 ident: bib2 article-title: Is increased time to diagnosis and treatment in symptomatic cancer associated with poorer outcomes? Systematic review publication-title: Br J Cancer – year: 2020 ident: bib1 article-title: Coronavirus (COVID-19) guidance – year: June 30, 2020 ident: bib36 article-title: British Society of Gastroenterology guidance on recommencing gastrointestinal endoscopy in the deceleration and early recovery phases of COVID-19 pandemic – year: 2020 ident: bib22 article-title: Collateral damage: the impact on outcomes from cancer surgery of the COVID-19 pandemic publication-title: Ann Oncol – year: 2020 ident: bib30 article-title: Disease control, civil liberties, and mass testing - calibrating restrictions during the COVID-19 pandemic publication-title: N Engl J Med – volume: 16 start-page: 933 year: 2016 ident: bib19 article-title: Analysing population-based cancer survival - settling the controversies publication-title: BMC Cancer – year: Aug 12, 2019 ident: bib37 article-title: Cancer survival in England - adults diagnosed – volume: 117 start-page: 888 year: 2017 end-page: 897 ident: bib40 article-title: Evidence of advanced stage colorectal cancer with longer diagnostic intervals: a pooled analysis of seven primary care cohorts comprising 11 720 patients in five countries publication-title: Br J Cancer – volume: 6 start-page: 101 year: 1961 end-page: 121 ident: bib20 article-title: The relative survival rate: a statistical methodology publication-title: Natl Cancer Inst Monogr – year: June 18, 2020 ident: bib25 article-title: Chart of the week: the alarming drop in referrals from GPs to hospital services since the COVID-19 outbreak – year: April 15, 2020 ident: bib10 article-title: Cancer referrals down by the 80 per cent in some areas as coronavirus fears keep patients from hospitals – year: March 20, 2020 ident: bib5 article-title: COVID-19 rapid guidelines: delivery of systemic anticancer treatments – year: July 26, 2017 ident: bib9 article-title: Suspected Cancer: recognition and referral – volume: 10 year: 2015 ident: bib31 article-title: Diagnostic intervals and its association with breast, prostate, lung and colorectal cancer survival in England: historical cohort study using the Clinical Practice Research Datalink publication-title: PLoS One – year: April 27, 2020 ident: bib28 article-title: Book an appointment using the NHS e-Referral Service – year: July 3, 2019 ident: bib14 article-title: Quality assurance of administrative data used in cancer registrations and cancer survival statistics – volume: 101 start-page: S9 year: 2009 end-page: S12 ident: bib33 article-title: Do diagnostic delays in cancer matter? publication-title: Br J Cancer – year: April 3, 2020 ident: bib8 article-title: Endoscopy activity and COVID-19: BSC and JAG guidance – volume: 21 start-page: 748 year: 2020 end-page: 750 ident: bib12 article-title: Impact of the COVID-19 pandemic on the symptomatic diagnosis of cancer: the view from primary care publication-title: Lancet Oncol – volume: 29 start-page: 520 year: 2015 end-page: 523 ident: bib34 article-title: Diagnostic delay and survival in high-grade gliomas - evidence of the ‘waiting time paradox’? publication-title: Br J Neurosurg – volume: 12 year: 2017 ident: bib15 article-title: Reproducibility, reliability and validity of population-based administrative health data for the assessment of cancer non-related comorbidities publication-title: PLoS One – year: April 5, 2020 ident: bib26 article-title: Coronavirus response could create ‘very serious unintended consequences’ – volume: 6 year: 2019 ident: bib29 article-title: Impact of introducing a faecal immunochemical test (FIT) for haemoglobin into primary care on the outcome of patients with new bowel symptoms: a prospective cohort study publication-title: BMJ Open Gastroenterol – year: April 22, 2020 ident: bib11 article-title: UK will need social distancing until the end of year, says Whitty – volume: 21 start-page: 748 year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib12 article-title: Impact of the COVID-19 pandemic on the symptomatic diagnosis of cancer: the view from primary care publication-title: Lancet Oncol doi: 10.1016/S1470-2045(20)30242-4 – year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib22 article-title: Collateral damage: the impact on outcomes from cancer surgery of the COVID-19 pandemic publication-title: Ann Oncol doi: 10.1016/j.annonc.2020.05.009 – year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib5 – volume: 6 start-page: 101 year: 1961 ident: 10.1016/S1470-2045(20)30388-0_bib20 article-title: The relative survival rate: a statistical methodology publication-title: Natl Cancer Inst Monogr – volume: 117 start-page: 888 year: 2017 ident: 10.1016/S1470-2045(20)30388-0_bib40 article-title: Evidence of advanced stage colorectal cancer with longer diagnostic intervals: a pooled analysis of seven primary care cohorts comprising 11 720 patients in five countries publication-title: Br J Cancer doi: 10.1038/bjc.2017.236 – volume: 24 start-page: 22 issue: suppl 2 year: 2015 ident: 10.1016/S1470-2045(20)30388-0_bib3 article-title: The signal and the noise in colorectal cancer diagnosis: exploring and explaining the relationship between diagnostic delays and stage at diagnosis using the Ca-PRI Colorectal Cancer Collaboration dataset publication-title: Eur J Cancer Care – volume: 32 start-page: 279 year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib6 article-title: Guidelines on radiation therapy for breast cancer during the COVID-19 pandemic publication-title: Clin Oncol doi: 10.1016/j.clon.2020.03.006 – volume: 10 year: 2015 ident: 10.1016/S1470-2045(20)30388-0_bib31 article-title: Diagnostic intervals and its association with breast, prostate, lung and colorectal cancer survival in England: historical cohort study using the Clinical Practice Research Datalink publication-title: PLoS One doi: 10.1371/journal.pone.0126608 – year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib10 – volume: 29 start-page: 520 year: 2015 ident: 10.1016/S1470-2045(20)30388-0_bib34 article-title: Diagnostic delay and survival in high-grade gliomas - evidence of the ‘waiting time paradox’? publication-title: Br J Neurosurg doi: 10.3109/02688697.2015.1012050 – year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib11 – year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib25 – volume: 108 start-page: 2205 year: 2013 ident: 10.1016/S1470-2045(20)30388-0_bib18 article-title: The benefits and harms of breast cancer screening: an independent review publication-title: Br J Cancer doi: 10.1038/bjc.2013.177 – ident: 10.1016/S1470-2045(20)30388-0_bib36 – volume: 12 year: 2017 ident: 10.1016/S1470-2045(20)30388-0_bib15 article-title: Reproducibility, reliability and validity of population-based administrative health data for the assessment of cancer non-related comorbidities publication-title: PLoS One doi: 10.1371/journal.pone.0172814 – year: 2019 ident: 10.1016/S1470-2045(20)30388-0_bib17 – volume: 101 start-page: S9 issue: suppl 2 year: 2009 ident: 10.1016/S1470-2045(20)30388-0_bib33 article-title: Do diagnostic delays in cancer matter? publication-title: Br J Cancer doi: 10.1038/sj.bjc.6605384 – volume: 107 start-page: 1220 year: 2012 ident: 10.1016/S1470-2045(20)30388-0_bib13 article-title: Routes to diagnosis for cancer - determining the patient journey using multiple routine data sets publication-title: Br J Cancer doi: 10.1038/bjc.2012.408 – year: 2018 ident: 10.1016/S1470-2045(20)30388-0_bib38 – year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib24 article-title: Resuming bowel cancer screening post-COVID-19 publication-title: Lancet Gastroenterol Hepatol – volume: 395 start-page: 1527 year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib27 article-title: What policy makers need to know about COVID-19 protective immunity publication-title: Lancet doi: 10.1016/S0140-6736(20)30985-5 – year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib30 article-title: Disease control, civil liberties, and mass testing - calibrating restrictions during the COVID-19 pandemic publication-title: N Engl J Med doi: 10.1056/NEJMp2007637 – year: 2019 ident: 10.1016/S1470-2045(20)30388-0_bib14 – volume: 6 year: 2019 ident: 10.1016/S1470-2045(20)30388-0_bib29 article-title: Impact of introducing a faecal immunochemical test (FIT) for haemoglobin into primary care on the outcome of patients with new bowel symptoms: a prospective cohort study publication-title: BMJ Open Gastroenterol doi: 10.1136/bmjgast-2019-000293 – volume: 36 start-page: 148 year: 2012 ident: 10.1016/S1470-2045(20)30388-0_bib21 article-title: Adjusting for the proportion of cancer deaths in the general population when using relative survival: a sensitivity analysis publication-title: Cancer Epidemiol doi: 10.1016/j.canep.2011.09.007 – volume: 1 start-page: 565 year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib23 article-title: The impact of the COVID-19 pandemic on cancer care publication-title: Nature Cancer doi: 10.1038/s43018-020-0074-y – year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib7 – volume: 112 start-page: S92 issue: suppl 1 year: 2015 ident: 10.1016/S1470-2045(20)30388-0_bib2 article-title: Is increased time to diagnosis and treatment in symptomatic cancer associated with poorer outcomes? Systematic review publication-title: Br J Cancer doi: 10.1038/bjc.2015.48 – year: 2008 ident: 10.1016/S1470-2045(20)30388-0_bib16 – volume: 16 start-page: 933 year: 2016 ident: 10.1016/S1470-2045(20)30388-0_bib19 article-title: Analysing population-based cancer survival - settling the controversies publication-title: BMC Cancer doi: 10.1186/s12885-016-2967-9 – year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib35 – year: 2019 ident: 10.1016/S1470-2045(20)30388-0_bib37 – year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib4 – volume: 14 start-page: 476 year: 2010 ident: 10.1016/S1470-2045(20)30388-0_bib32 article-title: Delay in diagnostic workup and treatment of esophageal cancer publication-title: J Gastrointest Surg doi: 10.1007/s11605-009-1109-y – year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib8 – year: 2017 ident: 10.1016/S1470-2045(20)30388-0_bib9 – volume: 155 start-page: 592 year: 2018 ident: 10.1016/S1470-2045(20)30388-0_bib39 article-title: Overdiagnosis in colorectal cancer screening: time to acknowledge a blind spot publication-title: Gastroenterology doi: 10.1053/j.gastro.2018.07.037 – year: 2020 ident: 10.1016/S1470-2045(20)30388-0_bib26 – reference: 33778775 - Lancet Rheumatol. 2021 Feb;3(2):e83. doi: 10.1016/S2665-9913(21)00001-1. – reference: 34049776 - Eur J Cancer. 2021 Jul;152:233-242. doi: 10.1016/j.ejca.2021.04.019. – reference: 33387506 - Lancet Oncol. 2021 Jan;22(1):e5. doi: 10.1016/S1470-2045(20)30752-X. – reference: 32702312 - Lancet Oncol. 2020 Aug;21(8):1000-1002. doi: 10.1016/S1470-2045(20)30391-0. – reference: 33053379 - Radiother Oncol. 2021 Feb;155:1-2. doi: 10.1016/j.radonc.2020.09.055. |
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| Title | The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study |
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