Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

Resistance to chemotherapy is a challenging problem for treatment of cancer patients and autophagy has been shown to mediate development of resistance. In this study we systematically screened a library of 306 known anti-cancer drugs for their ability to induce autophagy using a cell-based assay. 11...

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Bibliographic Details
Published in:	Cancer letters Vol. 435; pp. 32 - 43
Main Authors:	Dyczynski, Matheus, Yu, Yasmin, Otrocka, Magdalena, Parpal, Santiago, Braga, Tiago, Henley, Aine Brigette, Zazzi, Henric, Lerner, Mikael, Wennerberg, Krister, Viklund, Jenny, Martinsson, Jessica, Grandér, Dan, De Milito, Angelo, Pokrovskaja Tamm, Katja
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 28.10.2018 Elsevier Limited
Subjects:	Autophagy Breast cancer Cancer therapies Cell culture Chemotherapy Combination therapy Cytotoxicity Drug development Drugs Erlotinib High-content screening Hypoxia Inhibitor drugs Kinases Libraries Medical screening Metabolism Oncology Phagocytosis Protein transport Protein-tyrosine kinase Proteins siRNA Spheroids Targeted cancer therapy Therapeutic applications Tumor cell lines Vps34 Xenografts Sweden MCL-1 Vps34 Chk1 Combination therapy Autophagy High-content screening GFP PI3P PI3K mTOR ATG7 LC3 NCOA4 AKT KU PROPPIN FGFR p62 CQ Erlotinib HCQ BafA1 HER2 MCS HDAC
ISSN:	0304-3835, 1872-7980, 1872-7980
Online Access:	Get full text
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