Pancreatic cancer circulating tumour cells express a cell motility gene signature that predicts survival after surgery

Background Most cancer deaths are caused by metastases, resulting from circulating tumor cells (CTC) that detach from the primary cancer and survive in distant organs. The aim of the present study was to develop a CTC gene signature and to assess its prognostic relevance after surgery for pancreatic...

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Bibliographic Details
Published in:	BMC cancer Vol. 12; no. 1; p. 527
Main Authors:	Sergeant, Gregory, van Eijsden, Rudy, Roskams, Tania, Van Duppen, Victor, Topal, Baki
Format:	Journal Article
Language:	English
Published:	London BioMed Central 16.11.2012 BioMed Central Ltd Springer Nature B.V
Subjects:	Adenocarcinoma - diagnosis Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - surgery Aged Analysis Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Bone morphogenetic proteins Cancer Cancer Research Cancer therapies Carcinoma, Pancreatic Ductal - diagnosis Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - mortality Carcinoma, Pancreatic Ductal - surgery Care and treatment Cell Line, Tumor DNA microarrays Female Fluorescence Gene expression Gene Expression Profiling Genes Genetic aspects Genomics Health Promotion and Disease Prevention Hematology Humans Information management Male Medical research Medicine/Public Health Metastasis Microarray Analysis Middle Aged Mitogens Motility Neoplastic Cells, Circulating - metabolism Oncology Oncology, Experimental Pancreas Pancreatic cancer Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - genetics Pancreatic Neoplasms - mortality Pancreatic Neoplasms - surgery Patient outcomes Predictive Value of Tests Prognosis Protein kinases Proteins Research Article RNA Statistical analysis Surgery Surgical Oncology Survival Analysis Transforming growth factors Translational oncology Cell motility Transforming growth factor - β1 Gene expression profiling Pancreatic ductal adenocarcinoma p38 – MAPK signaling Circulating tumour cells Cancer cell migration
ISSN:	1471-2407, 1471-2407
Online Access:	Get full text
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