Compartmentalized Human Immunodeficiency Virus Type 1 Originates from Long-Lived Cells in Some Subjects with HIV-1–Associated Dementia

Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) shortly after systemic infection and can result in the subsequent development of HIV-1-associated dementia (HAD) in a subset of infected individuals. Genetically compartmentalized virus in the CNS is associated with...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 5; no. 4; p. e1000395
Main Authors:	Schnell, Gretja, Spudich, Serena, Harrington, Patrick, Price, Richard W., Swanstrom, Ronald
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.04.2009 Public Library of Science (PLoS)
Subjects:	AIDS Dementia Complex - pathology AIDS Dementia Complex - virology Antiretroviral drugs Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Blood - virology Brain CD4-Positive T-Lymphocytes - pathology CD4-Positive T-Lymphocytes - virology Cellular Senescence Central nervous system Central Nervous System - virology Cerebrospinal Fluid - virology Dementia Drug therapy Experiments Genetic aspects Genetic Variation Half-Life Health aspects HIV HIV (Viruses) HIV Infections - complications HIV Infections - pathology HIV Infections - virology HIV-1 - genetics Human immunodeficiency virus Humans Infections Leukocytosis Macrophages - pathology Macrophages - virology Neurological Disorders/Infectious Diseases of the Nervous System Physiological aspects Plasma Risk factors Studies T cells Virology/Immunodeficiency Viruses United States
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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