Simultaneous CXCL12 and ESR1 CpG island hypermethylation correlates with poor prognosis in sporadic breast cancer

Background CXCL12 is a chemokine that is constitutively expressed in many organs and tissues. CXCL12 promoter hypermethylation has been detected in primary breast tumours and contributes to their metastatic potential. It has been shown that the oestrogen receptor α ( ESR1 ) gene can also be silenced...

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Bibliographic Details
Published in:	BMC cancer Vol. 10; no. 1; p. 23
Main Authors:	Ramos, Edneia AS, Camargo, Anamaria A, Braun, Karin, Slowik, Renata, Cavalli, Iglenir J, Ribeiro, Enilze MSF, Pedrosa, Fábio de O, de Souza, Emanuel M, Costa, Fabrício F, Klassen, Giseli
Format:	Journal Article
Language:	English
Published:	London BioMed Central 28.01.2010 BioMed Central Ltd BMC
Subjects:	Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Research Cell Line, Tumor Chemokine CXCL12 - biosynthesis Chemokine CXCL12 - genetics Chemokines CpG Islands Development and progression DNA Methylation DNA Mutational Analysis Estrogen Estrogen Receptor alpha - biosynthesis Estrogen Receptor alpha - genetics Female Gene Silencing Genetic aspects Genetic Predisposition to Disease Health Promotion and Disease Prevention Humans Immunohistochemistry Medicine/Public Health Methylation Middle Aged Oncology Physiological aspects Prognosis Promoter Regions, Genetic Receptors Research Article Reverse Transcriptase Polymerase Chain Reaction Risk factors Surgical Oncology United States CXCL12 Expression Breast Tumour Cell Line ESR1 Gene Primary Breast Tumour Normal Cell Line
ISSN:	1471-2407, 1471-2407
Online Access:	Get full text
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