Precision medicine for cancer with next-generation functional diagnostics

Genome-based cancer therapeutic matching is limited by incomplete biological understanding of the relationship between phenotype and cancer genotype. This Opinion article proposes that this limitation can be addressed by functional testing of live patient tumour cells exposed to potential therapies....

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Veröffentlicht in:	Nature reviews. Cancer Jg. 15; H. 12; S. 747 - 756
Hauptverfasser:	Friedman, Adam A., Letai, Anthony, Fisher, David E., Flaherty, Keith T.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.12.2015 Nature Publishing Group
Schlagworte:	631/154/140 631/208/191 631/208/212/2166 631/67/1059 631/67/69 Biomedicine Cancer Cancer Research Care and treatment DNA sequencing Genomics - methods High-Throughput Nucleotide Sequencing - methods Humans Methods Molecular Diagnostic Techniques - methods Neoplasms - diagnosis Neoplasms - genetics Nucleotide sequencing Oncology, Experimental opinion-2 Precision Medicine
ISSN:	1474-175X, 1474-1768, 1474-1768
Online-Zugang:	Volltext
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