Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data

Background Target genes of a transcription factor (TF) Pou5f1 ( Oct3/4 or Oct4 ), which is essential for pluripotency maintenance and self-renewal of embryonic stem (ES) cells, have previously been identified based on their response to Pou5f1 manipulation and occurrence of Chromatin-immunoprecipitat...

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Bibliographic Details
Published in:	BMC genomics Vol. 9; no. 1; p. 269
Main Authors:	Sharov, Alexei A, Masui, Shinji, Sharova, Lioudmila V, Piao, Yulan, Aiba, Kazuhiro, Matoba, Ryo, Xin, Li, Niwa, Hitoshi, Ko, Minoru SH
Format:	Journal Article
Language:	English
Published:	London BioMed Central 03.06.2008 BioMed Central Ltd BMC
Subjects:	Algorithms Analysis Animal Genetics and Genomics Animals Binding Sites Biomedical and Life Sciences Chromatin Chromatin Immunoprecipitation - methods DNA binding proteins DNA microarrays DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryonic Stem Cells - metabolism Genetic aspects Genome Health aspects HMGB Proteins - genetics HMGB Proteins - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Life Sciences Mice Microarrays Microbial Genetics and Genomics Nanog Homeobox Protein Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Oligonucleotide Array Sequence Analysis Plant Genetics and Genomics Proteomics Research Article SOXB1 Transcription Factors Time Factors Transcription Factors - genetics Transcription Factors - metabolism United States False Discovery Rate Trophoblast Stem Cell Trophoblast Stem Embryonic Stem Cell ChIP Data
ISSN:	1471-2164, 1471-2164
Online Access:	Get full text
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