The influence of brain iron on myelin water imaging

With myelin playing a vital role in normal brain integrity and function and thus in various neurological disorders, myelin sensitive magnetic resonance imaging (MRI) techniques are of great importance. In particular, multi-exponential T2 relaxation was shown to be highly sensitive to myelin. The mye...

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Vydané v:NeuroImage (Orlando, Fla.) Ročník 199; s. 545 - 552
Hlavní autori: Birkl, Christoph, Birkl-Toeglhofer, Anna Maria, Endmayr, Verena, Höftberger, Romana, Kasprian, Gregor, Krebs, Claudia, Haybaeck, Johannes, Rauscher, Alexander
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Elsevier Inc 01.10.2019
Elsevier Limited
Predmet:
Aged
Aged, 80 and over
Autopsy
Body Water - diagnostic imaging
Brain
Brain research
Engineering research
Female
Humans
Iron
Iron - metabolism
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
Myelin
Myelin Sheath - metabolism
Myelin water imaging
Neuroimaging
Neuroimaging - methods
Neurological diseases
NMR
Nuclear magnetic resonance
Oligodendrocytes
Quantitative MRI
Signal transduction
Substantia alba
White matter
White Matter - diagnostic imaging
White Matter - metabolism
Canada
Brain
Iron
Quantitative MRI
Myelin
White matter
Myelin water imaging
ISSN:1053-8119, 1095-9572, 1095-9572
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Popis
Shrnutí:With myelin playing a vital role in normal brain integrity and function and thus in various neurological disorders, myelin sensitive magnetic resonance imaging (MRI) techniques are of great importance. In particular, multi-exponential T2 relaxation was shown to be highly sensitive to myelin. The myelin water imaging (MWI) technique allows to separate the T2 decay into short components, specific to myelin water, and long components reflecting the intra- and extracellular water. The myelin water fraction (MWF) is the ratio of the short components to all components. In the brain's white matter (WM), myelin and iron are closely linked via the presence of iron in the myelin generating oligodendrocytes. Iron is known to decrease T2 relaxation times and may therefore mimic myelin. In this study, we investigated if variations in WM iron content can lead to apparent MWF changes. We performed MWI in post mortem human brain tissue prior and after chemical iron extraction. Histology for iron and myelin confirmed a decrease in iron content and no change in myelin content after iron extraction. In MRI, iron extraction lead to a decrease in MWF by 26%–28% in WM. Thus, a change in MWF does not necessarily reflect a change in myelin content. This observation has important implications for the interpretation of MWI findings in previously published studies and future research. •MWI was performed in post mortem brain samples before and after iron extraction.•After iron extraction, apparent myelin water fraction was reduced by 26%.•Global geometric mean T2 increased by 31% after iron extraction.•Histology confirmed removal of iron but showed no change in staining for myelin.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1053-8119
1095-9572
1095-9572
DOI:10.1016/j.neuroimage.2019.05.042