The structure of the serotonin system: A PET imaging study

The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of homogeneous 5-HT receptors and transporter is not aligned with such brain regions. This discrepancy indicates that a neocortical parcellation specifi...

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Vydáno v:NeuroImage (Orlando, Fla.) Ročník 205; s. 116240
Hlavní autoři: Beliveau, Vincent, Ozenne, Brice, Strother, Stephen, Greve, Douglas N., Svarer, Claus, Knudsen, Gitte Moos, Ganz, Melanie
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 15.01.2020
Elsevier Limited
Elsevier
Témata:
Adult
Atlases as Topic
Brain
Brain - diagnostic imaging
Brain - metabolism
Cluster Analysis
Clustering
Datasets
Humans
Magnetic Resonance Imaging - methods
Medical imaging
MRI
mRNA
Neocortex
Neuroimaging
Neuroimaging - methods
PET
Positron emission tomography
Positron-Emission Tomography - methods
Receptors, Serotonin - metabolism
RNA, Messenger - metabolism
Serotonin
Serotonin - genetics
Serotonin - metabolism
Spatial distribution
Structure
mRNA
Serotonin
Clustering
Structure
MRI
PET
ISSN:1053-8119, 1095-9572, 1095-9572
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Popis
Shrnutí:The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of homogeneous 5-HT receptors and transporter is not aligned with such brain regions. This discrepancy indicates that a neocortical parcellation specific to the 5-HT system is needed. We first outline issues with an existing parcellation of the 5-HT system, and present an alternative parcellation derived from brain MR- and high-resolution PET images of five different 5-HT targets from 210 healthy controls. We then explore how well this new 5-HT parcellation can explain mRNA levels of all 5-HT genes. The parcellation derived here represents a characterization of the 5-HT system which is more stable and explains the underlying 5-HT molecular imaging data better than other atlases, and may hence be more sensitive to capture region-specific changes modulated by 5-HT. •We evaluate a previous parcellation of the 5-HT system and propose an improvement.•Our new parcellation achieves a higher explained variance and is more stable.•The parcellation includes less regions, so region-based analysis are less penalized.•mRNA data for the HTR1A, HTR1F and HTR2C genes are well captured by the parcellation.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1053-8119
1095-9572
1095-9572
DOI:10.1016/j.neuroimage.2019.116240