IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis

In subjects with psoriasis, inflammation and epidermal hyperplasia are thought to be controlled by T cell–derived cytokines. Evidence suggests that the TH17 cell cytokine IL-17A (IL-17) might play a role in disease pathogenesis. We sought to understand the effect that neutralization of IL-17 has on...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 130; no. 1; pp. 145 - 154.e9
Main Authors:	Krueger, James G., Fretzin, Scott, Suárez-Fariñas, Mayte, Haslett, Patrick A., Phipps, Krista M., Cameron, Gregory S., McColm, Juliet, Katcherian, Artemis, Cueto, Inna, White, Traci, Banerjee, Subhashis, Hoffman, Robert W.
Format:	Journal Article
Language:	English
Published:	New York, NY Mosby, Inc 01.07.2012 Elsevier Elsevier Limited
Subjects:	Allergy and Immunology Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - immunology Antibodies, Monoclonal, Humanized - therapeutic use Biological and medical sciences Chemokines Clinical trials Cloning dendritic cells Dermatology dermis dose response Dose-Response Relationship, Drug Drug dosages drugs Fundamental and applied biological sciences. Psychology Fundamental immunology Gene expression genes Humans hyperplasia IL-17 Immunopathology inflammation Inflammation - genetics Inflammation - immunology Inflammation - metabolism interleukin-17 Interleukin-17 - genetics Interleukin-17 - immunology Interleukin-17 - metabolism keratinocytes Lymphocyte Activation Lymphocytes Medical sciences messenger RNA microarray technology Molecular Sequence Data neutralization Oligonucleotide Array Sequence Analysis Pathogenesis placebos Psoriasis Psoriasis - immunology Psoriasis - physiopathology Psoriasis - therapy Psoriasis. Parapsoriasis. Lichen Reverse Transcriptase Polymerase Chain Reaction Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin Skin - immunology Skin - metabolism Skin - physiopathology skin lesions T-lymphocytes TH17 cells Th17 Cells - immunology TNF Treatment Outcome tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism PASI Psoriasis IL-17 DEG PASI 75 DC-LAMP TH17 cells TNF At least a 75% improvement in PASI score T H17 cells Differentially expressed gene Dendritic cell-lysosomal associated membrane protein Psoriasis Area and Severity Index Human Immunopathology Skin disease Cytokine Helper cell Activation Circuit Inflammation Interleukin 17 Immunology Gene T Tumor necrosis factor Genetics 17 cells Th17 lymphocyte
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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