Inflammatory breast cancer (IBC): clues for targeted therapies

Inflammatory breast cancer (IBC) is the most aggressive type of advanced breast cancer characterized by rapid proliferation, early metastatic development and poor prognosis. Since there are few preclinical models of IBC, there is a general lack of understanding of the complexity of the disease. Rece...

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Bibliographic Details
Published in:	Breast cancer research and treatment Vol. 140; no. 1; pp. 23 - 33
Main Authors:	Fernandez, Sandra V., Robertson, Fredika M., Pei, Jianming, Aburto-Chumpitaz, Lucy, Mu, Zhaomei, Chu, Khoi, Alpaugh, R. K., Huang, Yong, Cao, Yu, Ye, Zaiming, Cai, Kathy Q., Boley, Kimberly M., Klein-Szanto, Andres J., Devarajan, Karthik, Addya, Sankar, Cristofanilli, Massimo
Format:	Journal Article
Language:	English
Published:	Boston Springer US 01.07.2013 Springer Springer Nature B.V
Subjects:	Adenosine Triphosphatases - genetics Analysis Anaplastic Lymphoma Kinase Animals ATPases Associated with Diverse Cellular Activities Biological and medical sciences Brain Neoplasms - pathology Brain Neoplasms - secondary Breast cancer Cadherins - metabolism Cancer research Cancer therapies CD4 Antigens - genetics Cell adhesion & migration Cell Line, Tumor Chromosomes, Human, Pair 8 DNA-Binding Proteins - genetics Epithelial-Mesenchymal Transition Female Focal Adhesion Kinase 1 - metabolism Focal Adhesion Kinase 2 - metabolism Gene Expression Regulation, Neoplastic Genes, myc Gynecology. Andrology. Obstetrics Humans Inflammatory Breast Neoplasms - genetics Inflammatory Breast Neoplasms - metabolism Inflammatory Breast Neoplasms - pathology Loss of Heterozygosity Lung Neoplasms - secondary Mammary gland diseases Medical sciences Medicine Medicine & Public Health Metastasis Mice Mice, SCID Molecular Targeted Therapy Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms, Experimental - genetics Neoplasms, Experimental - pathology Oncology Preclinical Study Prognosis Receptor Protein-Tyrosine Kinases - genetics Receptor, Notch3 Receptors, Notch - genetics Tumors Xenograft Model Antitumor Assays ALK NOTCH3 MYC FAK1/PTK2 CD44 ATAD2 Transmembrane protein Breast disease Targeted therapy Notch3 gene Cell adhesion molecule Breast cancer Inflammation Malignant tumor Mammary gland diseases Treatment C-Onc gene myc Gene Anaplastic lymphoma kinase Protooncogene Cancer
ISSN:	0167-6806, 1573-7217, 1573-7217
Online Access:	Get full text
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