Connectome-wide structure-function coupling models implicate polysynaptic alterations in autism

•We studied structure-function coupling in autism using a Riemannian optimization.•Higher coupling was observed when polysynaptic mechanisms were accounted for.•Compensation was lower in autism, particularly in transmodal association systems.•Structure-function differences in autism reflected autist...

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Bibliographic Details
Published in:	NeuroImage (Orlando, Fla.) Vol. 285; p. 120481
Main Authors:	Park, Bo-yong, Benkarim, Oualid, Weber, Clara F., Kebets, Valeria, Fett, Serena, Yoo, Seulki, Martino, Adriana Di, Milham, Michael P., Misic, Bratislav, Valk, Sofie L., Hong, Seok-Jun, Bernhardt, Boris C.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.01.2024 Elsevier Limited Elsevier
Subjects:	Autism Autism Spectrum Disorder Autistic Disorder - diagnostic imaging Brain Brain Mapping - methods Communication Connectome - methods Diffusion time Humans Magnetic resonance imaging Magnetic Resonance Imaging - methods Neural networks Neuroimaging Predictions Radiology/Diagnostic Imaging Scanners Structure-function coupling Structure-function relationships Synaptic communication Structure-function coupling Autism Diffusion time Synaptic communication
ISSN:	1053-8119, 1095-9572, 1095-9572
Online Access:	Get full text
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