Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part Phase Ib/II study
Uloženo v:
| Vydáno v: | Leukemia Ročník 34; číslo 8; s. 2234 - 2237 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
Nature Publishing Group UK
01.08.2020
Nature Publishing Group Springer Nature |
| Témata: | |
| ISSN: | 0887-6924, 1476-5551, 1476-5551 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Audience | Academic |
|---|---|
| Author | Mesa, Ruben A. Pezzutto, Antonio Bettica, Paolo Manzoni, Sara McMullin, Mary Frances Gesullo, Francesca Rambaldi, Alessandro Carli, Giuseppe Luciani, Stefania von Bubnoff, Nikolas Marolleau, Jean-Pierre Guarini, Attilio Cambier, Nathalie Tibes, Raoul Di Tollo, Silvia De Muro, Marianna Iurlo, Alessandra Noble, Richard Martino, Bruno Pancrazzi, Alessandro Vannucchi, Alessandro M. |
| Author_xml | – sequence: 1 givenname: Alessandro orcidid: 0000-0002-3739-7502 surname: Rambaldi fullname: Rambaldi, Alessandro email: alessandro.rambaldi@unimi.it organization: Department of Oncology and Hematology, University of Milan and ASST Papa Giovanni XXIII – sequence: 2 givenname: Alessandra orcidid: 0000-0002-4401-0812 surname: Iurlo fullname: Iurlo, Alessandra organization: Hematology Division, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico – sequence: 3 givenname: Alessandro M. surname: Vannucchi fullname: Vannucchi, Alessandro M. organization: Department of Experimental and Clinical Medicine, University of Florence, Azienda Ospedaliera-Universitaria Careggi – sequence: 4 givenname: Richard surname: Noble fullname: Noble, Richard organization: Department of Hematology, Royal Cornwall Hospital – sequence: 5 givenname: Nikolas surname: von Bubnoff fullname: von Bubnoff, Nikolas organization: Department of Hematology, Oncology and Stem Cell Transplantation, Medical Center, Faculty of Medicine, University of Freiburg, Department of Hematology and Oncology, Medical Center, University of Schleswig-Holstein – sequence: 6 givenname: Attilio surname: Guarini fullname: Guarini, Attilio organization: Hematology Unit, IRCCS Istituto Tumori “Giovanni Paolo II” – sequence: 7 givenname: Bruno surname: Martino fullname: Martino, Bruno organization: Oncology-Hematology Department, A.O. “Bianchi-Melacrino-Morelli” – sequence: 8 givenname: Antonio orcidid: 0000-0002-3246-4470 surname: Pezzutto fullname: Pezzutto, Antonio organization: Department of Hematology Oncology, Charité’ Medical School – sequence: 9 givenname: Giuseppe surname: Carli fullname: Carli, Giuseppe organization: U.O. Hematology, San Bortolo Hospital – sequence: 10 givenname: Marianna surname: De Muro fullname: De Muro, Marianna organization: Hematology and Stem Cells Transplantation Unit, Campus Bio-Medico, University Hospital – sequence: 11 givenname: Stefania surname: Luciani fullname: Luciani, Stefania organization: U.O. Clinical Hematology, Presidio Ospedaliero “Spirito Santo”—A.S.L. Azienda Sanitaria Locale – sequence: 12 givenname: Mary Frances orcidid: 0000-0002-0773-0204 surname: McMullin fullname: McMullin, Mary Frances organization: Centre for Medical Education, Queen’s University Belfast – sequence: 13 givenname: Nathalie surname: Cambier fullname: Cambier, Nathalie organization: Service d’Oncologie Hématologie, Hospital Saint Vincent de Paul—GHICL Lille – sequence: 14 givenname: Jean-Pierre surname: Marolleau fullname: Marolleau, Jean-Pierre organization: Service d’Oncologie Hématologie Clinique, CHU Amiens—Hospital Sud – sequence: 15 givenname: Ruben A. surname: Mesa fullname: Mesa, Ruben A. organization: Mayo Clinic Cancer Center – sequence: 16 givenname: Raoul surname: Tibes fullname: Tibes, Raoul organization: New York University School of Medicine & Perlmutter Cancer Center/ NYU Langone Health – sequence: 17 givenname: Alessandro surname: Pancrazzi fullname: Pancrazzi, Alessandro organization: Department of Experimental and Clinical Medicine, University of Florence, Azienda Ospedaliera-Universitaria Careggi – sequence: 18 givenname: Francesca surname: Gesullo fullname: Gesullo, Francesca organization: Department of Experimental and Clinical Medicine, University of Florence, Azienda Ospedaliera-Universitaria Careggi – sequence: 19 givenname: Paolo surname: Bettica fullname: Bettica, Paolo organization: Clinical R&D Department, Italfarmaco S.p.A – sequence: 20 givenname: Sara surname: Manzoni fullname: Manzoni, Sara organization: Clinical R&D Department, Italfarmaco S.p.A – sequence: 21 givenname: Silvia surname: Di Tollo fullname: Di Tollo, Silvia organization: Clinical R&D Department, Italfarmaco S.p.A |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32047238$$D View this record in MEDLINE/PubMed https://u-picardie.hal.science/hal-03604943$$DView record in HAL |
| BookMark | eNp9kl9rFDEUxYNUbLv6AXyRgCD6MG3-TZLxQViK2oUFBfU5ZJPMbsrMZJ1kVufbm2Fr21205CGQ-zu5NyfnHJx0oXMAvMToAiMqLyPDVJQFIqhAgpbF-AScYSZ4UZYlPgFnSEpR8IqwU3Ae4w1CU5E_A6eUICYIlWeg_6Zrl0aoOwtdXXujzQhDDdPGwVb_9u3QwhQa1-vkLLQhuqm69jvfhZh0gr6D29CMZsyK1mu4y-h7qGH6FYqt7hP8utFZtFhdLhYwpsGOz8HTWjfRvbjdZ-DHp4_fr66L5ZfPi6v5sjCcolQQKri0tRSsEo5aSVhNaudWpSE8AxVimFfGIkcc5tYaRpnRlmFpuSst1nQGPuzv3Q6r1lnjutTrRm173-p-VEF7dVjp_Eatw04JKgXNhs7Au_0FmyPZ9XyppjNEOWIVozuc2be3zfrwc3AxqdZH45pGdy4MURFa5nkpI1VGXx-hN2Hou2yFIiy_VnIu8OMUESUVFZP31Fo3TvmuDvklZmqt5tkkKYnM6Axc_IPKy-YvMzlTtc_nB4I3DwQbp5u0iaEZkg9dPARfPfT4zqW_AcsA3gOmDzH2rr5DMFJTiNU-xCqHWE0hVmPWiCON8TlquXce2zePKsleGXOXbu36e9P-L_oDzqcC5A |
| CitedBy_id | crossref_primary_10_3389_fimmu_2022_841716 crossref_primary_10_1016_S2152_2650_22_00647_4 crossref_primary_10_3390_ijms22020659 crossref_primary_10_3390_cimb47040227 crossref_primary_10_1007_s11899_021_00630_8 crossref_primary_10_1007_s11899_022_00670_8 crossref_primary_10_1080_14728222_2020_1762176 crossref_primary_10_1002_psp4_13087 crossref_primary_10_1080_14656566_2024_2396029 crossref_primary_10_1016_j_hoc_2021_01_003 crossref_primary_10_1080_13543784_2020_1761323 crossref_primary_10_3390_cancers12102891 crossref_primary_10_1186_s13045_020_00995_y crossref_primary_10_1038_s41408_021_00445_z crossref_primary_10_1038_s41572_025_00608_3 crossref_primary_10_2147_TCRM_S213020 crossref_primary_10_1016_j_beha_2022_101370 crossref_primary_10_1038_s41392_024_02039_0 crossref_primary_10_7759_cureus_14193 crossref_primary_10_1007_s12185_022_03336_6 crossref_primary_10_1080_10428194_2021_1901092 crossref_primary_10_1038_s41392_023_01342_6 crossref_primary_10_3390_ijms21165805 crossref_primary_10_1126_scitranslmed_abg3277 crossref_primary_10_3389_fneur_2023_1095121 crossref_primary_10_1007_s40265_024_02052_1 crossref_primary_10_1186_s40364_021_00298_5 crossref_primary_10_1016_j_clml_2023_11_004 crossref_primary_10_3390_biomedicines10123008 |
| Cites_doi | 10.1182/blood.V128.22.475.475 10.1002/cam4.2147 10.1007/s00277-019-03654-6 10.1038/sj.thj.6200250 10.1038/leu.2008.280 10.1182/blood.2019000428 10.1097/MOH.0b013e3283257a9e 10.1111/j.1365-2141.2010.08266.x 10.1111/bjh.12416 10.1038/sj.leu.2405049 10.1111/bjh.12332 10.1007/s00277-017-3225-1 10.1111/bjh.15648 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2020 COPYRIGHT 2020 Nature Publishing Group The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Distributed under a Creative Commons Attribution 4.0 International License |
| Copyright_xml | – notice: The Author(s) 2020 – notice: COPYRIGHT 2020 Nature Publishing Group – notice: The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Distributed under a Creative Commons Attribution 4.0 International License |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7RV 7T5 7T7 7TM 7TO 7U9 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB0 LK8 M0S M1P M7N M7P NAPCQ P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 1XC 5PM |
| DOI | 10.1038/s41375-020-0735-y |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Nursing & Allied Health Database Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Proquest Health and Medical Complete ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Database ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Nursing & Allied Health Premium Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic Hyper Article en Ligne (HAL) PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection ProQuest Medical Library Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1476-5551 |
| EndPage | 2237 |
| ExternalDocumentID | PMC7387307 oai:HAL:hal-03604943v1 A630882875 32047238 10_1038_s41375_020_0735_y |
| Genre | Letter Multicenter Study Clinical Trial, Phase II Clinical Trial, Phase I Research Support, Non-U.S. Gov't |
| GrantInformation_xml | – fundername: This study was funded by Italfarmaco S.p.A. – fundername: ; |
| GroupedDBID | --- .XZ 0R~ 29L 36B 39C 4.4 406 53G 5GY 5RE 70F 7RV 7X7 88E 8AO 8C1 8FI 8FJ 8R4 8R5 AACDK AANZL AASDW AASML AATNV AAWTL AAYZH AAZLF ABAKF ABJNI ABLJU ABOCM ABUWG ABZZP ACAOD ACGFO ACGFS ACKTT ACMJI ACPRK ACRQY ACZOJ ADBBV ADHDB AEFQL AEJRE AEMSY AENEX AEVLU AEXYK AFBBN AFKRA AFRAH AFSHS AGAYW AGHAI AGQEE AHMBA AHSBF AIGIU AILAN AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF ASPBG AVWKF AXYYD AZFZN BBNVY BENPR BHPHI BKEYQ BKKNO BPHCQ BVXVI C6C CCPQU CS3 DNIVK DPUIP DU5 E3Z EAP EBLON EBS EE. EIOEI ESX EX3 F5P FDQFY FEDTE FERAY FIGPU FSGXE FYUFA HCIFZ HMCUK HVGLF HZ~ IAO IH2 IHR IHW INH INR ITC IWAJR JSO JZLTJ KQ8 LGEZI LOTEE M1P M7P N9A NADUK NAPCQ NQJWS NXXTH O9- OK1 P2P PQQKQ PROAC PSQYO Q2X RNT RNTTT ROL SNX SNYQT SOHCF SOJ SRMVM SWTZT TAOOD TBHMF TDRGL TEORI TSG UKHRP WOW -Q- 2WC AAYXX ABBRH ABDBE ABFSG ABRTQ ACSTC AEZWR AFDZB AFHIU AHWEU AIXLP ATHPR AYFIA CITATION DIK TUS .55 3V. AAQQT ABAWZ ABDBF ACUHS AFFNX B0M BAWUL CAG CGR COF CUY CVF EAD EBC EBD EBX ECM EIF EJD EMB EMK EMOBN EPL FIZPM NAO NPM OVD P6G RNS SV3 TR2 UDS X7M Y6R ZGI ZXP ~8M ACMFV PHGZM PHGZT 7QL 7T5 7T7 7TM 7TO 7U9 7XB 8FD 8FE 8FH 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. LK8 M7N P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS 7X8 PUEGO 1XC AFFHD 5PM |
| ID | FETCH-LOGICAL-c630t-23768df87497e3d824f2feeb5c26630904169cd0e2e16ddc434cad418d6e5d1a3 |
| IEDL.DBID | 7X7 |
| ISICitedReferencesCount | 34 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000512844400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0887-6924 1476-5551 |
| IngestDate | Tue Nov 04 01:59:48 EST 2025 Sat Nov 29 15:07:42 EST 2025 Fri Sep 05 14:26:19 EDT 2025 Mon Oct 06 17:16:08 EDT 2025 Mon Oct 06 17:17:24 EDT 2025 Sat Nov 29 13:22:39 EST 2025 Sat Nov 29 10:03:12 EST 2025 Thu May 22 21:24:17 EDT 2025 Wed Feb 19 02:10:06 EST 2025 Tue Nov 18 22:26:26 EST 2025 Sat Nov 29 02:21:51 EST 2025 Fri Feb 21 02:38:40 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| License | Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c630t-23768df87497e3d824f2feeb5c26630904169cd0e2e16ddc434cad418d6e5d1a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Correspondence-3 content type line 23 PMCID: PMC7387307 |
| ORCID | 0000-0002-3246-4470 0000-0002-0773-0204 0000-0002-4401-0812 0000-0002-3739-7502 0009-0008-1282-023X |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC7387307 |
| PMID | 32047238 |
| PQID | 2427537948 |
| PQPubID | 30521 |
| PageCount | 4 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7387307 hal_primary_oai_HAL_hal_03604943v1 proquest_miscellaneous_2354163429 proquest_journals_2474986671 proquest_journals_2427537948 gale_infotracmisc_A630882875 gale_infotracacademiconefile_A630882875 gale_healthsolutions_A630882875 pubmed_primary_32047238 crossref_primary_10_1038_s41375_020_0735_y crossref_citationtrail_10_1038_s41375_020_0735_y springer_journals_10_1038_s41375_020_0735_y |
| PublicationCentury | 2000 |
| PublicationDate | 2020-08-01 |
| PublicationDateYYYYMMDD | 2020-08-01 |
| PublicationDate_xml | – month: 08 year: 2020 text: 2020-08-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Leukemia |
| PublicationTitleAbbrev | Leukemia |
| PublicationTitleAlternate | Leukemia |
| PublicationYear | 2020 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Springer Nature |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Springer Nature |
| References | Kiladjian, Guglielmelli, Griesshammer, Saydam, Masszi, Durrant (CR14) 2018; 97 Guerini, Barbui, Spinelli, Salvi, Dellacasa, Carobbio (CR8) 2008; 22 Mesa (CR4) 2017; 15 Andersen, McMullin, Ejerblad, Zweegman, Harrison, Fernandes (CR15) 2013; 162 Gisslinger, Klade, Georgiev, Skotnicki, Gercheva-Kyuchukova, Egyed (CR12) 2016; 128 McMullin, Harrison, Ali, Cargo, Chen, Ewing (CR1) 2019; 184 Kiladjian, Chomienne, Fenaux (CR6) 2008; 22 Demuynck, Verhoef, Delforge, Vandenberghe, Devos (CR2) 2019; 98 Kiladjian, Gardin, Renoux, Bruno, Bernard (CR5) 2003; 4 Pugliese, Giordano, Nappi, Luciano, Cerchione, Annunziata (CR13) 2019; 8 Rambaldi, Dellacasa, Finazzi, Carobbio, Ferrari, Guglielmelli (CR9) 2010; 150 Barosi, Rosti (CR11) 2009; 16 Kiladjian, Cassinat, Soret-Dulphy, Verger, Roy, Rey (CR3) 2017; 102 Yacoub, Mascarenhas, Kosiorek, Prchal, Berenzon, Baer (CR7) 2019; 134 Finazzi, Vannucchi, Martinelli, Ruggeri, Nobile, Specchia (CR10) 2013; 161 A Rambaldi (735_CR9) 2010; 150 RA Mesa (735_CR4) 2017; 15 A Yacoub (735_CR7) 2019; 134 H Gisslinger (735_CR12) 2016; 128 J-J Kiladjian (735_CR5) 2003; 4 N Pugliese (735_CR13) 2019; 8 T Demuynck (735_CR2) 2019; 98 J-J Kiladjian (735_CR6) 2008; 22 G Finazzi (735_CR10) 2013; 161 CL Andersen (735_CR15) 2013; 162 J-J Kiladjian (735_CR14) 2018; 97 G Barosi (735_CR11) 2009; 16 J-J Kiladjian (735_CR3) 2017; 102 V Guerini (735_CR8) 2008; 22 MF McMullin (735_CR1) 2019; 184 |
| References_xml | – volume: 128 start-page: 475 year: 2016 ident: CR12 article-title: Final results from PROUD-PV a randomized controlled Phase 3 trial comparing ropeginterferon alfa-2b to hydroxyurea in polycythemia vera patients publication-title: Blood doi: 10.1182/blood.V128.22.475.475 – volume: 8 start-page: 2802 year: 2019 end-page: 9 ident: CR13 article-title: Adding hydroxyurea in combination with ruxolitinib improves clinical responses in hyperproliferative forms of myelofibrosis publication-title: Cancer Med doi: 10.1002/cam4.2147 – volume: 98 start-page: 1421 year: 2019 end-page: 6 ident: CR2 article-title: Polycythemia vera and hydroxyurea resistance/intolerance: a monocentric retrospective analysis publication-title: Ann Hematol doi: 10.1007/s00277-019-03654-6 – volume: 4 start-page: 198 year: 2003 end-page: 207 ident: CR5 article-title: Long-term outcomes of polycythemia vera patients treated with pipobroman as initial therapy publication-title: Hematol J doi: 10.1038/sj.thj.6200250 – volume: 22 start-page: 1990 year: 2008 end-page: 8 ident: CR6 article-title: Interferon-alpha therapy in bcr-abl-negative myeloproliferative neoplasms publication-title: Leukemia doi: 10.1038/leu.2008.280 – volume: 102 start-page: S787 year: 2017 ident: CR3 article-title: Molecular response to hydroxyurea and ropeginterferon alfa-2B in the PROUD-PV randomized Phase 3 trial publication-title: Haematologica – volume: 15 start-page: 848 year: 2017 end-page: 50 ident: CR4 article-title: New guidelines from the NCCN for polycythemia vera publication-title: Clin Adv Hematol Oncol – volume: 134 start-page: 1498 year: 2019 end-page: 509 ident: CR7 article-title: Pegylated interferon alfa-2a for polycythemia vera or essential thrombocythemia resistant or intolerant to hydroxyurea publication-title: Blood doi: 10.1182/blood.2019000428 – volume: 16 start-page: 129 year: 2009 end-page: 34 ident: CR11 article-title: Novel strategies for patients with chronic myeloproliferative disorders publication-title: Curr Opin Hematol doi: 10.1097/MOH.0b013e3283257a9e – volume: 150 start-page: 446 year: 2010 end-page: 55 ident: CR9 article-title: A pilot study of the histone-deacetylase inhibitor givinostat in patients with JAK2V617F positive chronic myeloproliferative neoplasms publication-title: Br J Haematol doi: 10.1111/j.1365-2141.2010.08266.x – volume: 162 start-page: 498 year: 2013 end-page: 508 ident: CR15 article-title: A phase II study of vorinostat (MK-0683) in patients with polycythaemia vera and essential thrombocythaemia publication-title: Br J Haematol doi: 10.1111/bjh.12416 – volume: 22 start-page: 740 year: 2008 end-page: 7 ident: CR8 article-title: The histone deacetylase inhibitor ITF2357 selectively targets cells bearing mutated JAK2V617F publication-title: Leukemia doi: 10.1038/sj.leu.2405049 – volume: 161 start-page: 688 year: 2013 end-page: 94 ident: CR10 article-title: A phase II study of givinostat in combination with hydroxycarbamide in patients with polycythaemia vera unresponsive to hydroxycarbamide monotherapy publication-title: Br J Haematol doi: 10.1111/bjh.12332 – volume: 97 start-page: 617 year: 2018 end-page: 27 ident: CR14 article-title: Efficacy and safety of ruxolitinib after and versus interferon use in the RESPONSE studies publication-title: Ann Hematol doi: 10.1007/s00277-017-3225-1 – volume: 184 start-page: 176 year: 2019 end-page: 91 ident: CR1 article-title: A guideline for the diagnosis and management of polycythaemia vera. A British Society for Haematology Guideline publication-title: Br J Haematol doi: 10.1111/bjh.15648 – volume: 15 start-page: 848 year: 2017 ident: 735_CR4 publication-title: Clin Adv Hematol Oncol – volume: 22 start-page: 740 year: 2008 ident: 735_CR8 publication-title: Leukemia doi: 10.1038/sj.leu.2405049 – volume: 16 start-page: 129 year: 2009 ident: 735_CR11 publication-title: Curr Opin Hematol doi: 10.1097/MOH.0b013e3283257a9e – volume: 98 start-page: 1421 year: 2019 ident: 735_CR2 publication-title: Ann Hematol doi: 10.1007/s00277-019-03654-6 – volume: 128 start-page: 475 year: 2016 ident: 735_CR12 publication-title: Blood doi: 10.1182/blood.V128.22.475.475 – volume: 134 start-page: 1498 year: 2019 ident: 735_CR7 publication-title: Blood doi: 10.1182/blood.2019000428 – volume: 162 start-page: 498 year: 2013 ident: 735_CR15 publication-title: Br J Haematol doi: 10.1111/bjh.12416 – volume: 22 start-page: 1990 year: 2008 ident: 735_CR6 publication-title: Leukemia doi: 10.1038/leu.2008.280 – volume: 102 start-page: S787 year: 2017 ident: 735_CR3 publication-title: Haematologica – volume: 150 start-page: 446 year: 2010 ident: 735_CR9 publication-title: Br J Haematol doi: 10.1111/j.1365-2141.2010.08266.x – volume: 8 start-page: 2802 year: 2019 ident: 735_CR13 publication-title: Cancer Med doi: 10.1002/cam4.2147 – volume: 4 start-page: 198 year: 2003 ident: 735_CR5 publication-title: Hematol J doi: 10.1038/sj.thj.6200250 – volume: 97 start-page: 617 year: 2018 ident: 735_CR14 publication-title: Ann Hematol doi: 10.1007/s00277-017-3225-1 – volume: 184 start-page: 176 year: 2019 ident: 735_CR1 publication-title: Br J Haematol doi: 10.1111/bjh.15648 – volume: 161 start-page: 688 year: 2013 ident: 735_CR10 publication-title: Br J Haematol doi: 10.1111/bjh.12332 |
| SSID | ssj0014766 |
| Score | 2.494907 |
| SourceID | pubmedcentral hal proquest gale pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 2234 |
| SubjectTerms | 631/136/232 631/532/1542 Adult Aged Aged, 80 and over Blood cancer Cancer Research Carbamates - adverse effects Carbamates - therapeutic use Critical Care Medicine Female Hematology Humans Intensive Internal Medicine Janus Kinase 2 - genetics Letter Life Sciences Male Maximum Tolerated Dose Medicine Medicine & Public Health Middle Aged Mutation Oncology Polycythemia Polycythemia vera Polycythemia Vera - drug therapy Polycythemia Vera - genetics Polycythemia Vera - psychology Quality of Life Vorinostat |
| Title | Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part Phase Ib/II study |
| URI | https://link.springer.com/article/10.1038/s41375-020-0735-y https://www.ncbi.nlm.nih.gov/pubmed/32047238 https://www.proquest.com/docview/2427537948 https://www.proquest.com/docview/2474986671 https://www.proquest.com/docview/2354163429 https://u-picardie.hal.science/hal-03604943 https://pubmed.ncbi.nlm.nih.gov/PMC7387307 |
| Volume | 34 |
| WOSCitedRecordID | wos000512844400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1476-5551 dateEnd: 20241213 omitProxy: false ssIdentifier: ssj0014766 issn: 0887-6924 databaseCode: 7RV dateStart: 19970201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELfYhhAvfH8URjEICYkpahInscsLKtOmVRpVNWDqW-TYDo3UJqVNC_nvucsXCtP2wkse6mvij7vzne_8O0LeMak8LcFykzqyLc91Ijxoii3YOlUcgHDxEvHm8pxPJmI2G07rA7dNnVbZ6MRSUetM4Rn5wPW4NxRBwJ1Pq58WVo3C6GpdQmOPHGDZbORzPmsdLsfjVawSBSkAR6OJajIx2IDy5ng32baAyX2r6OxLtXbem2Ny5FXL82oC5T9R1HJzOr3_v8N6QO7VZikdVXz0kNwy6SNy50sdeH9M1l9lbPKCylRTg6gTUhU0iymYj3QpfyfL7ZLm2QIRmo2mOtsYbP2R7JI0wztLNEnpKlsUqkCU2ERSkCD5kUqa_8qsFbAvnc5hP6XjaDAe0xLz9gn5fnry7fjMqss1WCpgdm5hfo3QsYABccO0cL3YjY2JfAVGALOHNth-Q6Vt4xon0Fp5zFNSe47QgfG1I9lTsp9mqXlOKLhZQCbBNVPlhhm5dhTEUrt-5CrueD1iN4sVqhrLHEtqLMIyps5EWK1vCOsb4vqGRY98aP-yqoA8biJ-jRwQVndRWyUQjmAcAksE-D3yvqRANQBfhlmvbjNA_xFQq0N52KEE8VWd5rfAZW2XEO37bHQe4m9gXCB6D9s58I6Ge8Jax2xCMK7A1wR9Kq5pbjirR960zfh1TKtLTbYFGuajQQ5T3CPPKpZue8JcBBJl8HLeYfZOV7staTIvAco5A1m0eY8cNWLxt1vXzvmLmwfxktx1S2nF3MtDsp-vt-YVua12ebJZ90HuLy77pfSXTwFPcez0ycHnk8n0oo8pvdM_12BhBg |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLa2gYAX7pfAYAaBkEBREzu3IiFUDaZW66ZJbGhvwbEdGqlNSpt25E_xGzknNxSm7W0PvNYnzrF7rvHxdwh5zYV0lIDITajIMh1mR_ihKTbBdcrYA-XyS8Sbb2P_8DA4Pe0fbZDfzV0YLKtsbGJpqFUm8Rt5jzm-0w88z7c_zX-a2DUKT1ebFhqVWOzr4gxStuXH0Wf4f98wtvfleHdo1l0FTOlxKzexDCRQcQDT-ZqrgDkxi7WOXAm-ilt9C0KUvlSWZtr2lJIOd6RQjh0oT7vKFhzm3STXHM44alGw25aU2I5fnY2i4nqQ2DSnqDzoLcFZ-HgX2jJBqVyz6PjB2htsTrAY83yke75g859T29IZ7t3537bxLrldh910UOnJPbKh0_vkxkFdWPCALL6KWOcFFamiGlE1hCxoFlMIj-lM_EpmqxnNsykiUGtFVbbUOPojWSdphneyaJLSeTYtZIEouImgYCHEBypofpaZc1BPejSBeIGOot5oREtM34fk5EpW_IhspVmqnxAKaSSQCUg9ZRkQRMyKvFgo5kZM-rZjEKsRjlDWWO3YMmQaljUDPAgreQpBnkKUp7AwyLv2kXkFVHIZ8Q5KXFjdtW2NXDiAdQTYAsE1yNuSAs0cvBl2vbqtAfwjYFiHcrtDCeZJdoZfgVS3LCGa-XAwDvE3CJ4QnYivbZijkdawtqHLEIJHyKXBXwQXDDeSbJCX7TC-HcsGU52tgIa7mHDAFhvkcaVCLSecIVAqh8n9jnJ1WO2OpMmkBGD3eQCO0TfI-0YN_7J14Z4_vXwRO-Tm8PhgHI5Hh_vPyC1WWgqsM90mW_lipZ-T63KdJ8vFi9LmUPL9qrXzDwo7uEA |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLa2Dk28cL8EBjMIhASKmsS5FQmhwlatWqkqGGhvwbEdGqlNSpt25K_x6zgnNxSm7W0PvPacOLZ7rvHxdwh5wbiwJYfIjcvQ0G3LDPFDU6SD6xSRC8rlFYg330beeOyfnvYmW-R3fRcGyyprm1gYapkK_EbetWzP7vmu65ndqCqLmBwM3i9-6thBCk9a63YapYgcq_wM0rfVu-EB_NcvLWtwePLxSK86DOjCZUamY0mILyMfhvYUk75lR1akVOgI8FvM6BkQrvSENJSlTFdKYTNbcGmbvnSVI03OYNxtsuMxSHo6ZOfD4XjyuTnDsL3ypBTV2IU0pz5TZX53Ba7Dw5vRhg4q5uh5yytWvmF7iqWZ5-Pe8-Wb_5zhFq5xcPN_3tRb5EYVkNN-qUG3yZZK7pDdT1XJwV2y_MIjleWUJ5IqxNvgIqdpRCFwpnP-K56v5zRLZ4hNrSSV6Uoh9Ue8iZMUb2vROKGLdJaLHPFxY07BdvC3lNPsLNUXoLh0MoVIgg7D7nBIC7Tfe-Trlaz4PukkaaIeEgoJJrBxSEpFESqElhG6EZeWE1rCM22NGLWgBKJCccdmIrOgqCZgflDKVgCyFaBsBblGXjePLEoIk8uY91H6gvIWbmP-gj6sw8fmCI5GXhUcaADhzbDr5T0OmD9CibU491qcYLhEi_wcJLyZEuKcH_VHAf4GYRXiFrGNCWPUkhtU1nUVQFgJWTZ4Ev8Cci3VGnnWkPHtWFCYqHQNPMzBVAS2WCMPSnVqZsIshFBlMLjXUrTWVNuUJJ4W0Owe88Flehp5U6vk32lduOePLl_EPtkFpQxGw_HxY3LdKowGFqDukU62XKsn5JrYZPFq-bQyQJR8v2r1_AMU_8Ke |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Safety+and+efficacy+of+the+maximum+tolerated+dose+of+givinostat+in+polycythemia+vera%3A+a+two-part+Phase+Ib%2FII+study&rft.jtitle=Leukemia&rft.au=Rambaldi%2C+Alessandro&rft.au=Iurlo%2C+Alessandra&rft.au=Vannucchi%2C+Alessandro+M.&rft.au=Noble%2C+Richard&rft.date=2020-08-01&rft.pub=Springer+Nature&rft.issn=0887-6924&rft.eissn=1476-5551&rft.volume=34&rft.issue=8&rft.spage=2234&rft.epage=2237&rft_id=info:doi/10.1038%2Fs41375-020-0735-y&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=oai%3AHAL%3Ahal-03604943v1 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0887-6924&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0887-6924&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0887-6924&client=summon |