Signatures of copy number alterations in human cancer

Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-related processes of replication stress, mitotic errors, spindle multipolarity and breakage–fusion–bridge cycles, among others, which may lead to chromosomal instability and aneuploidy 1 , 2 . These copy number alte...

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Bibliographic Details
Published in:	Nature (London) Vol. 606; no. 7916; pp. 984 - 991
Main Authors:	Steele, Christopher D., Abbasi, Ammal, Islam, S. M. Ashiqul, Bowes, Amy L., Khandekar, Azhar, Haase, Kerstin, Hames-Fathi, Shadi, Ajayi, Dolapo, Verfaillie, Annelien, Dhami, Pawan, McLatchie, Alex, Lechner, Matt, Light, Nicholas, Shlien, Adam, Malkin, David, Feber, Andrew, Proszek, Paula, Lesluyes, Tom, Mertens, Fredrik, Flanagan, Adrienne M., Tarabichi, Maxime, Van Loo, Peter, Alexandrov, Ludmil B., Pillay, Nischalan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 30.06.2022 Nature Publishing Group
Subjects:	13 13/31 45/22 45/23 45/61 631/114/2785 631/67/69 Aneuploidy Basic Medicine Bisulfite Cancer Cancer and Oncology Cancer och onkologi Chromosomes Chromothripsis Clinical Medicine Copy number Deoxyribonucleic acid DNA DNA Copy Number Variations - genetics DNA microarrays DNA Mutational Analysis DNA sequencing Exome Sequencing Genomes Genomic instability Haploidy Health risks Heterozygosity Homologous recombination Homologous Recombination - genetics Homology Humanities and Social Sciences Humans Klinisk medicin Loss of heterozygosity Loss of Heterozygosity - genetics MDM2 protein Medical and Health Sciences Medical Genetics and Genomics (including Gene Therapy) Medicin och hälsovetenskap Medicinsk genetik och genomik (Här ingår: Genterapi) Medicinska och farmaceutiska grundvetenskaper multidisciplinary Mutation Neoplasms - genetics Neoplasms - pathology Ovaries Risk analysis Risk factors Science Science (multidisciplinary) Signatures Whole genome sequencing
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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