Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 1...

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Vydáno v:	Nature genetics Ročník 54; číslo 4; s. 437 - 449
Hlavní autoři:	Okbay, Aysu, Wu, Yeda, Wang, Nancy, Jayashankar, Hariharan, Bennett, Michael, Nehzati, Seyed Moeen, Sidorenko, Julia, Kweon, Hyeokmoon, Goldman, Grant, Gjorgjieva, Tamara, Jiang, Yunxuan, Hicks, Barry, Tian, Chao, Hinds, David A., Ahlskog, Rafael, Magnusson, Patrik K. E., Oskarsson, Sven, Hayward, Caroline, Campbell, Archie, Porteous, David J., Freese, Jeremy, Herd, Pamela, Watson, Chelsea, Jala, Jonathan, Conley, Dalton, Koellinger, Philipp D., Johannesson, Magnus, Laibson, David, Meyer, Michelle N., Lee, James J., Kong, Augustine, Yengo, Loic, Cesarini, David, Turley, Patrick, Visscher, Peter M., Beauchamp, Jonathan P., Benjamin, Daniel J., Young, Alexander I.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.04.2022 Nature Publishing Group
Témata:	631/208/1515 631/208/205/2138 Agriculture Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Cancer Research Education Educational attainment Gene Function genetics Genome-wide association studies Genome-Wide Association Study Genomes Genotype & phenotype Gynaecology, Obstetrics and Reproductive Medicine Gynekologi, obstetrik och reproduktionsmedicin Human Genetics Humans Meta-analysis Multifactorial Inheritance Multifactorial Inheritance - genetics Nucleotides Phenotypes Polymorphism Polymorphism, Single Nucleotide - genetics Quantitative genetics Single Nucleotide Single-nucleotide polymorphism X chromosomes
ISSN:	1061-4036, 1546-1718, 1546-1718
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