Effect of a single exacerbation on decline in lung function in COPD

COPD exacerbations are associated with accelerated lung function decline, but whether they are causal is unknown. We evaluated the effect of a single exacerbation on rate of lung function change using data from the 4-year Understanding Potential Long-term Impacts on Function with Tiotropium (UPLIFT®...

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Vydáno v:	Respiratory Medicine Ročník 128; s. 85 - 91
Hlavní autoři:	Halpin, David M.G., Decramer, Marc, Celli, Bartolome R., Mueller, Achim, Metzdorf, Norbert, Tashkin, Donald P.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 01.07.2017 Elsevier BV Elsevier Limited
Témata:	Administration, Inhalation Adrenal Cortex Hormones Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - pharmacology Adrenergic beta-2 Receptor Agonists Adrenergic beta-2 Receptor Agonists - administration & dosage Adrenergic beta-2 Receptor Agonists - pharmacology Aged Bronchitis Bronchodilator Bronchodilator Agents Bronchodilator Agents - therapeutic use Bronchodilators Chronic obstructive pulmonary disease COPD Disease Progression Exacerbation Female Forced Expiratory Volume Forced Expiratory Volume - drug effects Gene expression Humans Inflammation Lung diseases Lung function decline Lungs Male Middle Aged Parasympatholytics Parasympatholytics - administration & dosage Parasympatholytics - pharmacology PFT Pulmonary Disease, Chronic Obstructive Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary function test Pulmonary/Respiratory Respiratory function Respiratory Function Tests Respiratory Function Tests - methods Retrospective Studies Scopolamine Derivatives Scopolamine Derivatives - therapeutic use Smoking Smoking - adverse effects Smoking - epidemiology Tiotropium Tiotropium Bromide Tiotropium Bromide - administration & dosage Tiotropium Bromide - pharmacology Treatment Outcome Understanding Potential Long-term Impacts on Function with Tiotropium UPLIFT Vital Capacity Vital Capacity - drug effects Wessex Classification Subject Headings::Respiratory medicine UPLIFT Exacerbation Tiotropium Pulmonary function test Understanding Potential Long-term Impacts on Function with Tiotropium Bronchodilator Lung function decline PFT COPD (max 6): bronchodilator Understanding potential long-term impacts on function with tiotropium UPLIFT(®)
ISSN:	0954-6111, 1532-3064, 1532-3064
On-line přístup:	Získat plný text
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