Lipid desaturation – the next step in targeting lipogenesis in cancer?

Metabolic reprogramming is a central feature of transformed cells. Cancer metabolism is now fully back in the focus of cancer research, as the interactions between oncogenic signalling and cellular metabolic processes are uncovered. One aspect of metabolic reprogramming in cancer is alterations in l...

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Bibliographic Details
Published in:	The FEBS journal Vol. 283; no. 15; pp. 2767 - 2778
Main Authors:	Peck, Barrie, Schulze, Almut
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01.08.2016
Subjects:	acyl coenzyme A Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cancer cell communication Cell Hypoxia cell viability clinical trials dietary fat Endoplasmic Reticulum Stress Fatty acids Fatty Acids - biosynthesis fatty-acid synthase Humans hypoxia lipid desaturation Lipid Metabolism lipid synthesis Lipids Lipids - physiology lipogenesis Lipogenesis - drug effects Metabolism microenvironment multiprotein complexes neoplasm cells neoplasms Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - metabolism SCD Stearoyl-CoA Desaturase - antagonists & inhibitors Stearoyl-CoA Desaturase - metabolism Sterol Regulatory Element Binding Proteins - physiology tissues microenvironment hypoxia lipid synthesis SCD lipid desaturation cancer metabolism
ISSN:	1742-464X, 1742-4658
Online Access:	Get full text
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