FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

BRCA1/2 proteins function in homologous recombination (HR)-mediated DNA repair and cooperate with Fanconi anemia (FA) proteins to maintain genomic integrity through replication fork stabilization. Loss of BRCA1/2 proteins results in DNA repair deficiency and replicative stress, leading to genomic in...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 15; no. 11; pp. 2488 - 2499
Main Authors:	Kais, Zeina, Rondinelli, Beatrice, Holmes, Amie, O’Leary, Colin, Kozono, David, D’Andrea, Alan D., Ceccaldi, Raphael
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 14.06.2016 Elsevier
Subjects:	Animals BRCA1 Protein - deficiency BRCA1 Protein - metabolism BRCA2 Protein - deficiency BRCA2 Protein - metabolism Carrier Proteins - metabolism Cell Line, Tumor Cell Survival DNA End-Joining Repair - genetics DNA Polymerase theta DNA Replication - genetics DNA-Directed DNA Polymerase - metabolism Endodeoxyribonucleases Fanconi Anemia Complementation Group D2 Protein - metabolism Genomic Instability Humans Mice, Nude Mutation - genetics Neoplasms - genetics Neoplasms - pathology Nuclear Proteins - metabolism Poly(ADP-ribose) Polymerases - metabolism Ubiquitination Up-Regulation - genetics
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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