Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

A functional genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions. Comparative metabolomics and lipidomics demonstrated that acetate is used as a nutritional source by cancer cells in an ACSS2-de...

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Veröffentlicht in:	Cancer cell Jg. 27; H. 1; S. 57
Hauptverfasser:	Schug, Zachary T, Peck, Barrie, Jones, Dylan T, Zhang, Qifeng, Grosskurth, Shaun, Alam, Israt S, Goodwin, Louise M, Smethurst, Elizabeth, Mason, Susan, Blyth, Karen, McGarry, Lynn, James, Daniel, Shanks, Emma, Kalna, Gabriela, Saunders, Rebecca E, Jiang, Ming, Howell, Michael, Lassailly, Francois, Thin, May Zaw, Spencer-Dene, Bradley, Stamp, Gordon, van den Broek, Niels J F, Mackay, Gillian, Bulusu, Vinay, Kamphorst, Jurre J, Tardito, Saverio, Strachan, David, Harris, Adrian L, Aboagye, Eric O, Critchlow, Susan E, Wakelam, Michael J O, Schulze, Almut, Gottlieb, Eyal
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 12.01.2015
Schlagworte:	Acetate-CoA Ligase - genetics Acetate-CoA Ligase - metabolism Animals Cell Line, Tumor Cell Proliferation Disease Progression Fatty Acids - metabolism Gene Dosage Gene Expression Regulation, Neoplastic Humans Hypoxia MCF-7 Cells Mice Mice, Nude Neoplasm Transplantation Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Stress, Physiological
ISSN:	1878-3686, 1878-3686
Online-Zugang:	Weitere Angaben
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