Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia

Studying mechanisms of malignant transformation of human pre-B cells, we found that acute activation of oncogenes induced immediate cell death in the vast majority of cells. Few surviving pre-B cell clones had acquired permissiveness to oncogenic signaling by strong activation of negative feedback r...

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Veröffentlicht in:	Cancer cell Jg. 28; H. 1; S. 114 - 128
Hauptverfasser:	Shojaee, Seyedmehdi, Caeser, Rebecca, Buchner, Maike, Park, Eugene, Swaminathan, Srividya, Hurtz, Christian, Geng, Huimin, Chan, Lai N, Klemm, Lars, Hofmann, Wolf-Karsten, Qiu, Yi Hua, Zhang, Nianxiang, Coombes, Kevin R, Paietta, Elisabeth, Molkentin, Jeffery, Koeffler, H Phillip, Willman, Cheryl L, Hunger, Stephen P, Melnick, Ari, Kornblau, Steven M, Müschen, Markus
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 13.07.2015
Schlagworte:	Animals Antineoplastic Agents - pharmacology Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Dual Specificity Phosphatase 6 - genetics Dual Specificity Phosphatase 6 - metabolism Host Cell Factor C1 Humans Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism MAP Kinase Signaling System - drug effects Membrane Proteins - antagonists & inhibitors Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Transgenic Molecular Sequence Data Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Prognosis Protein Serine-Threonine Kinases Small Molecule Libraries - pharmacology Transcription Factors - genetics Transcription Factors - metabolism
ISSN:	1878-3686
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