Identification of the Common Origins of Osteoclasts, Macrophages, and Dendritic Cells in Human Hematopoiesis

Osteoclasts (OCs) originate from the myeloid cell lineage, but the successive steps in their lineage commitment are ill-defined, especially in humans. To clarify OC origin, we sorted cell populations from pediatric bone marrow (BM) by flow cytometry and assessed their differentiation potential in vi...

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Bibliographic Details
Published in:	Stem cell reports Vol. 4; no. 6; pp. 984 - 994
Main Authors:	Xiao, Yanling, Zijl, Sebastiaan, Wang, Liqin, de Groot, Daniel C., van Tol, Maarten J., Lankester, Arjan C., Borst, Jannie
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 09.06.2015 Elsevier
Subjects:	Antigens, CD34 - metabolism Base Sequence Bone Marrow Cells - cytology Bone Marrow Cells - metabolism CD11b Antigen - metabolism Cell Differentiation Cell Lineage Dendritic Cells - cytology Dendritic Cells - metabolism fms-Like Tyrosine Kinase 3 - metabolism Gene Expression Profiling Hematopoiesis High-Throughput Nucleotide Sequencing Humans Interleukin-3 Receptor alpha Subunit - metabolism Macrophages - cytology Macrophages - metabolism Molecular Sequence Data Osteoclasts - cytology Osteoclasts - metabolism Proto-Oncogene Proteins c-kit - metabolism RNA, Messenger - chemistry RNA, Messenger - metabolism Sequence Analysis, DNA Transcriptome
ISSN:	2213-6711, 2213-6711
Online Access:	Get full text
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