Identification of the Common Origins of Osteoclasts, Macrophages, and Dendritic Cells in Human Hematopoiesis

Osteoclasts (OCs) originate from the myeloid cell lineage, but the successive steps in their lineage commitment are ill-defined, especially in humans. To clarify OC origin, we sorted cell populations from pediatric bone marrow (BM) by flow cytometry and assessed their differentiation potential in vi...

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Veröffentlicht in:	Stem cell reports Jg. 4; H. 6; S. 984 - 994
Hauptverfasser:	Xiao, Yanling, Zijl, Sebastiaan, Wang, Liqin, de Groot, Daniel C., van Tol, Maarten J., Lankester, Arjan C., Borst, Jannie
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 09.06.2015 Elsevier
Schlagworte:	Antigens, CD34 - metabolism Base Sequence Bone Marrow Cells - cytology Bone Marrow Cells - metabolism CD11b Antigen - metabolism Cell Differentiation Cell Lineage Dendritic Cells - cytology Dendritic Cells - metabolism fms-Like Tyrosine Kinase 3 - metabolism Gene Expression Profiling Hematopoiesis High-Throughput Nucleotide Sequencing Humans Interleukin-3 Receptor alpha Subunit - metabolism Macrophages - cytology Macrophages - metabolism Molecular Sequence Data Osteoclasts - cytology Osteoclasts - metabolism Proto-Oncogene Proteins c-kit - metabolism RNA, Messenger - chemistry RNA, Messenger - metabolism Sequence Analysis, DNA Transcriptome
ISSN:	2213-6711, 2213-6711
Online-Zugang:	Volltext
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