A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order

Hay fever or seasonal allergic rhinitis (AR) is a chronic disorder associated with IgE sensitization to grass. The underlying genetic variants have not been studied comprehensively. There is overwhelming evidence that those who have older siblings have less AR, although the mechanism for this remain...

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Vydané v:	Journal of allergy and clinical immunology Ročník 128; číslo 5; s. 996 - 1005
Hlavní autori:	Ramasamy, Adaikalavan, Curjuric, Ivan, Coin, Lachlan J., Kumar, Ashish, McArdle, Wendy L., Imboden, Medea, Leynaert, Benedicte, Kogevinas, Manolis, Schmid-Grendelmeier, Peter, Pekkanen, Juha, Wjst, Matthias, Bircher, Andreas J., Sovio, Ulla, Rochat, Thierry, Hartikainen, Anna-Liisa, Balding, David J., Jarvelin, Marjo-Riitta, Probst-Hensch, Nicole, Strachan, David P., Jarvis, Deborah L.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York, NY Mosby, Inc 01.11.2011 Elsevier Elsevier Limited
Predmet:	Adult adults Allergies Allergy and Immunology atopic dermatitis Biological and medical sciences Birth Order British 1958 Birth Cohort eczema European Community Respiratory Health Survey Female Fundamental and applied biological sciences. Psychology Fundamental immunology gene-environment interaction genes Genetic Predisposition to Disease - genetics genetic variation Genome-Wide Association Study Genomes Genotype grasses Hay fever Humans Hygiene hygiene hypothesis Hypotheses IgE sensitization to grass immunoglobulin E Immunopathology loci Male Medical sciences meta-analysis Non tumoral diseases Northern Finland Birth Cohort of 1966 older siblings open reading frames Otorhinolaryngology. Stomatology Pathogenesis phenotype Poaceae - immunology Polymorphism, Single Nucleotide protective effect Rhinitis, Allergic, Seasonal - genetics Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis siblings single nucleotide polymorphism Software solutes Studies Swiss Study on Air Pollution and Lung Disease in Adults Toll-like receptor 6 Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Switzerland Europe Finland B58C GWAS hygiene hypothesis TSLP European Community Respiratory Health Survey gene-environment interaction NOD1 Hay fever TMEM232 AR British 1958 Birth Cohort ECRHS IgE sensitization to grass SNP Swiss Study on Air Pollution and Lung Disease in Adults NFBC1966 genome-wide association study STAT6 older siblings TLR6 SAPALDIA Northern Finland Birth Cohort of 1966 SLC25A46 Transmembrane protein 232 Signal transducer and activator of transcription 6 Allergic rhinitis Nucleotide-binding oligomerization domain containing 1 Toll-like receptor 6 Thymic stromal lymphopoietin Solute carrier family 25 member 46 Single nucleotide polymorphism Allergy Nose disease Rhinitis IgE Birth order Sibling Respiratory system Hypothesis Metaanalysis Association Immunology ENT disease Adult Birth cohort Community health Sensitization Age Human Immunopathology Lung disease Respiratory disease Genetic variant Survey Genotype environment interaction Surveillance European community Air pollution Genome Elderly Hygiene
ISSN:	0091-6749, 1097-6825, 1097-6825
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