Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of hos...

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Veröffentlicht in:Emerging microbes & infections Jg. 9; H. 1; S. 761 - 770
Hauptverfasser: Xiong, Yong, Liu, Yuan, Cao, Liu, Wang, Dehe, Guo, Ming, Jiang, Ao, Guo, Dong, Hu, Wenjia, Yang, Jiayi, Tang, Zhidong, Wu, Honglong, Lin, Yongquan, Zhang, Meiyuan, Zhang, Qi, Shi, Mang, Liu, Yingle, Zhou, Yu, Lan, Ke, Chen, Yu
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Taylor & Francis 01.01.2020
Taylor & Francis Ltd
Taylor & Francis Group
Schlagworte:
Apoptosis
Betacoronavirus
Bronchoalveolar Lavage Fluid
Chemokines - analysis
Coronavirus Infections - blood
Coronavirus Infections - genetics
Coronavirus Infections - immunology
Coronaviruses
COVID-19
cytokine
Cytokines
Cytokines - analysis
Humans
inflammation
Lavage
Leukocytes, Mononuclear
Lymphopenia
Pandemics
Pneumonia, Viral - blood
Pneumonia, Viral - genetics
Pneumonia, Viral - immunology
RNA-Seq
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Signal Transduction
Transcriptome
transcriptome profiling
Tumor Suppressor Protein p53
COVID-19
cytokine
transcriptome profiling
inflammation
lymphopenia
ISSN:2222-1751, 2222-1751
Online-Zugang:Volltext
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Zusammenfassung:Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. To characterize the transcriptional signatures of host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing of the RNAs isolated from the bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) specimens of COVID-19 patients. Our results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/MIP1B. Furthermore, SARS-CoV-2 induced activation of apoptosis and P53 signalling pathway in lymphocytes may be the cause of patients' lymphopenia. The transcriptome dataset of COVID-19 patients would be a valuable resource for clinical guidance on anti-inflammatory medication and understanding the molecular mechansims of host response.
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These authors contributed equally to this work.
Supplemental data for this article can be accessed at https://doi.org/10.1080/22221751.2020.1747363
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2020.1747363