Methods for making induced pluripotent stem cells: reprogramming à la carte

Key Points Direct reprogramming enables the generation of pluripotent stem-cell lines from almost any somatic tissue and mammalian species, thereby avoiding the ethical issues associated with human embryonic stem cells. Although direct reprogramming is conceptually and technically simple, it is an e...

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Bibliographic Details
Published in:	Nature reviews. Genetics Vol. 12; no. 4; pp. 231 - 242
Main Authors:	González, Federico, Boué, Stéphanie, Belmonte, Juan Carlos Izpisúa
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.04.2011 Nature Publishing Group
Subjects:	631/136/2444 631/532/2064/2158 631/532/2435 Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cell culture Cell Differentiation Cell lines Cell Physiological Phenomena Cell proliferation Cellular Reprogramming - physiology Chromatin Comparative analysis Efficiency Embryo cells Epigenetics Fibroblasts Fundamental and applied biological sciences. Psychology Gene Function Gene therapy Genetics of eukaryotes. Biological and molecular evolution Genomes Health aspects Human Genetics Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism KLF4 protein Laboratories Mice miRNA mRNA Myc protein Oct-4 protein Physiological aspects Pluripotency Pluripotent Stem Cells - physiology review-article Somatic cells Stem cell transplantation Stem cells Toxicity Transcription factors Transplantation Whole genome sequencing Spain Cellular reprogramming Induced pluripotent stem cell Review Method
ISSN:	1471-0056, 1471-0064, 1471-0064
Online Access:	Get full text
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