Nedd4‐mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking

J. Neurochem. (2011) 119, 27–39. α‐Amino‐3‐hydroxy‐5‐methyl‐isoxazole‐4‐propionic acid receptors (AMPARs) are the primary mediators of excitatory synaptic transmission in the brain. Alterations in AMPAR localization and turnover have been considered critical mechanisms underpinning synaptic plastici...

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Bibliographic Details
Published in:	Journal of neurochemistry Vol. 119; no. 1; pp. 27 - 39
Main Authors:	Lin, Amy, Hou, Qingming, Jarzylo, Larissa, Amato, Steve, Gilbert, James, Shang, Fu, Man, Heng‐Ye
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01.10.2011 Wiley-Blackwell
Subjects:	AMPA receptors Animals Biological and medical sciences Blotting, Western Cell receptors Cell structures and functions Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors E3 ligase Electrophysiological Phenomena Endosomal Sorting Complexes Required for Transport - physiology Excitatory Postsynaptic Potentials - physiology Female Fundamental and applied biological sciences. Psychology glutamate receptors Humans Immunoprecipitation Lysine - metabolism Molecular and cellular biology Molecular biology Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Mutation Nedd4 Nedd4 Ubiquitin Protein Ligases Neural Stem Cells - physiology Neurochemistry Neurons Neurons - drug effects Neurons - metabolism Patch-Clamp Techniques Pregnancy Proteasome Endopeptidase Complex - metabolism Rats Receptors, AMPA - metabolism Receptors, Cell Surface - metabolism Synaptic Transmission - physiology trafficking Ubiquitin-Protein Ligases - physiology ubiquitination Ubiquitination - physiology Vertebrates: nervous system and sense organs Stability E3 ligase Central nervous system Nedd4 Alteration Glutamate receptor Cell surface Encephalon Endocytosis AMPA receptor Neuron Synaptic transmission ubiquitination Synaptic plasticity Mutation AMPA receptors Localization trafficking Biological receptor glutamate receptors
ISSN:	0022-3042, 1471-4159, 1471-4159
Online Access:	Get full text
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