Long-term cardiovascular disorders in the STOX1 mouse model of preeclampsia

Adverse long-term cardiovascular (CV) consequences of PE are well established in women. However, the mechanism responsible for that risk remains unknown. Here, we mated wild-type female mice of the FVB/N strain to STOX1A-overexpressing mice to mimic severe PE and investigated the long-term consequen...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Scientific reports Ročník 9; číslo 1; s. 11918 - 13
Hlavní autoři: Miralles, Francisco, Collinot, Hélène, Boumerdassi, Yasmine, Ducat, Aurélien, Duché, Angéline, Renault, Gilles, Marchiol, Carmen, Lagoutte, Isabelle, Bertholle, Céline, Andrieu, Muriel, Jacques, Sébastien, Méhats, Céline, Vaiman, Daniel
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 15.08.2019
Nature Publishing Group
Témata:
45/61
59
631/443/592/1540
631/443/592/75/243/793
64/60
Animals
Body Weight
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnostic imaging
Cardiovascular Diseases - etiology
Cardiovascular Diseases - genetics
Cardiovascular system
Carrier Proteins - metabolism
Cellular stress response
Chemokines
CXCL11 protein
CXCL13 protein
CXCL16 protein
Cytokines - metabolism
Deregulation
Disease Models, Animal
Doppler effect
Endothelial cells
Endothelial Cells - metabolism
Female
Females
Fibrosis
Gene Expression Regulation
Heart
Histology
Humanities and Social Sciences
Hypertrophy
Interleukin 10
Interleukin 16
Interleukin 2
Interleukin 4
Interleukin 6
Life Sciences
multidisciplinary
Myocardium - pathology
Organ Size
Pre-eclampsia
Pre-Eclampsia - blood
Pre-Eclampsia - pathology
Preeclampsia
Pregnancy
Reproductive Biology
Rodents
Science
Science (multidisciplinary)
Transcription, Genetic
Ultrasonic imaging
Ultrasound
Ventricle
ISSN:2045-2322, 2045-2322
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Adverse long-term cardiovascular (CV) consequences of PE are well established in women. However, the mechanism responsible for that risk remains unknown. Here, we mated wild-type female mice of the FVB/N strain to STOX1A-overexpressing mice to mimic severe PE and investigated the long-term consequences on the maternal cardiovascular system. Ultrasonography parameters were analyzed in mice before pregnancy and at 3 and 6 months post-pregnancy. At 6 months post-pregnancy, cardiac stress test induced by dobutamine injection revealed an abnormal ultrasonography Doppler profile in mice with previous PE. Eight months post-pregnancy, the heart, endothelial cells (ECs) and plasma of females were analyzed and compared to controls. The heart of mice with PE showed left-ventricular hypertrophy associated with altered histology (fibrosis). Transcriptomic analysis revealed the deregulation of 1149 genes in purified ECs and of 165 genes in the hearts, many being involved in heart hypertrophy. In ECs, the upregulated genes were associated with inflammation and cellular stress. Systems biology analysis identified interleukin 6 (IL-6) as a hub gene connecting these pathways. Plasma profiling of 33 cytokines showed that, 8 of them (Cxcl13, Cxcl16, Cxcl11, IL-16, IL-10, IL-2, IL-4 and Ccl1) allowed to discriminate mice with previous PE from controls. Thus, PE triggers female long-term CV consequences on the STOX1 mouse model.
AbstractList Adverse long-term cardiovascular (CV) consequences of PE are well established in women. However, the mechanism responsible for that risk remains unknown. Here, we mated wild-type female mice of the FVB/N strain to STOX1A-overexpressing mice to mimic severe PE and investigated the long-term consequences on the maternal cardiovascular system. Ultrasonography parameters were analyzed in mice before pregnancy and at 3 and 6 months post-pregnancy. At 6 months post-pregnancy, cardiac stress test induced by dobutamine injection revealed an abnormal ultrasonography Doppler profile in mice with previous PE. Eight months post-pregnancy, the heart, endothelial cells (ECs) and plasma of females were analyzed and compared to controls. The heart of mice with PE showed left-ventricular hypertrophy associated with altered histology (fibrosis). Transcriptomic analysis revealed the deregulation of 1149 genes in purified ECs and of 165 genes in the hearts, many being involved in heart hypertrophy. In ECs, the upregulated genes were associated with inflammation and cellular stress. Systems biology analysis identified interleukin 6 (IL-6) as a hub gene connecting these pathways. Plasma profiling of 33 cytokines showed that, 8 of them (Cxcl13, Cxcl16, Cxcl11, IL-16, IL-10, IL-2, IL-4 and Ccl1) allowed to discriminate mice with previous PE from controls. Thus, PE triggers female long-term CV consequences on the STOX1 mouse model.
Adverse long-term cardiovascular (CV) consequences of PE are well established in women. However, the mechanism responsible for that risk remains unknown. Here, we mated wild-type female mice of the FVB/N strain to STOX1A-overexpressing mice to mimic severe PE and investigated the long-term consequences on the maternal cardiovascular system. Ultrasonography parameters were analyzed in mice before pregnancy and at 3 and 6 months post-pregnancy. At 6 months post-pregnancy, cardiac stress test induced by dobutamine injection revealed an abnormal ultrasonography Doppler profile in mice with previous PE. Eight months post-pregnancy, the heart, endothelial cells (ECs) and plasma of females were analyzed and compared to controls. The heart of mice with PE showed left-ventricular hypertrophy associated with altered histology (fibrosis). Transcriptomic analysis revealed the deregulation of 1149 genes in purified ECs and of 165 genes in the hearts, many being involved in heart hypertrophy. In ECs, the upregulated genes were associated with inflammation and cellular stress. Systems biology analysis identified interleukin 6 (IL-6) as a hub gene connecting these pathways. Plasma profiling of 33 cytokines showed that, 8 of them (Cxcl13, Cxcl16, Cxcl11, IL-16, IL-10, IL-2, IL-4 and Ccl1) allowed to discriminate mice with previous PE from controls. Thus, PE triggers female long-term CV consequences on the STOX1 mouse model.Adverse long-term cardiovascular (CV) consequences of PE are well established in women. However, the mechanism responsible for that risk remains unknown. Here, we mated wild-type female mice of the FVB/N strain to STOX1A-overexpressing mice to mimic severe PE and investigated the long-term consequences on the maternal cardiovascular system. Ultrasonography parameters were analyzed in mice before pregnancy and at 3 and 6 months post-pregnancy. At 6 months post-pregnancy, cardiac stress test induced by dobutamine injection revealed an abnormal ultrasonography Doppler profile in mice with previous PE. Eight months post-pregnancy, the heart, endothelial cells (ECs) and plasma of females were analyzed and compared to controls. The heart of mice with PE showed left-ventricular hypertrophy associated with altered histology (fibrosis). Transcriptomic analysis revealed the deregulation of 1149 genes in purified ECs and of 165 genes in the hearts, many being involved in heart hypertrophy. In ECs, the upregulated genes were associated with inflammation and cellular stress. Systems biology analysis identified interleukin 6 (IL-6) as a hub gene connecting these pathways. Plasma profiling of 33 cytokines showed that, 8 of them (Cxcl13, Cxcl16, Cxcl11, IL-16, IL-10, IL-2, IL-4 and Ccl1) allowed to discriminate mice with previous PE from controls. Thus, PE triggers female long-term CV consequences on the STOX1 mouse model.
Adverse long-term cardiovascular (CV) consequences of PE are well established in women. However, the mechanism responsible for that risk remains unknown. Here, we mated wild-type female mice of the FVB/N strain to STOX1A-overexpressing mice to mimic severe PE and investigated the long-term consequences on the maternal cardiovascular system. Ultrasonography parameters were analyzed in mice before pregnancy and at 3 and 6 months post-pregnancy. At 6 months post-pregnancy, cardiac stress test induced by dobutamine injection revealed an abnormal ultrasonography Doppler profile in mice with previous PE. Eight months post-pregnancy, the heart, endothelial cells (ECs) and plasma of females were analyzed and compared to controls. The heart of mice with PE showed left-ventricular hypertrophy associated with altered histology (fibrosis). Transcriptomic analysis revealed the deregulation of 1149 genes in purified ECs and of 165 genes in the hearts, many being involved in heart hypertrophy. In ECs, the upregulated genes were associated with inflammation and cellular stress. Systems biology analysis identified interleukin 6 (IL-6) as a hub gene connecting these pathways. Plasma profiling of 33 cytokines showed that, 8 of them (Cxcl13, Cxcl16, Cxcl11, IL-16, IL-10, IL-2, IL-4 and Ccl1) allowed to discriminate mice with previous PE from controls. Thus, PE triggers female long-term CV consequences on the STOX1 mouse model.
ArticleNumber 11918
Author Vaiman, Daniel
Marchiol, Carmen
Méhats, Céline
Ducat, Aurélien
Lagoutte, Isabelle
Jacques, Sébastien
Andrieu, Muriel
Duché, Angéline
Miralles, Francisco
Collinot, Hélène
Boumerdassi, Yasmine
Renault, Gilles
Bertholle, Céline
Author_xml – sequence: 1
  givenname: Francisco
  surname: Miralles
  fullname: Miralles, Francisco
  organization: Institut Cochin, U1016 INSERM - UMR8104, CNRS – Université Paris Descartes, Team “From Gametes To Birth”
– sequence: 2
  givenname: Hélène
  surname: Collinot
  fullname: Collinot, Hélène
  organization: Institut Cochin, U1016 INSERM - UMR8104, CNRS – Université Paris Descartes, Team “From Gametes To Birth”
– sequence: 3
  givenname: Yasmine
  surname: Boumerdassi
  fullname: Boumerdassi, Yasmine
  organization: Institut Cochin, U1016 INSERM - UMR8104, CNRS – Université Paris Descartes, Team “From Gametes To Birth”
– sequence: 4
  givenname: Aurélien
  surname: Ducat
  fullname: Ducat, Aurélien
  organization: Institut Cochin, U1016 INSERM - UMR8104, CNRS – Université Paris Descartes, Team “From Gametes To Birth”
– sequence: 5
  givenname: Angéline
  surname: Duché
  fullname: Duché, Angéline
  organization: Institut Cochin, U1016 INSERM - UMR8104, CNRS – Université Paris Descartes, Genom’IC Platform, Bâtiment Gustave Roussy
– sequence: 6
  givenname: Gilles
  surname: Renault
  fullname: Renault, Gilles
  organization: Institut Cochin, U1016 INSERM - UMR8104, CNRS – Université Paris Descartes, PIV Platform
– sequence: 7
  givenname: Carmen
  surname: Marchiol
  fullname: Marchiol, Carmen
  organization: Institut Cochin, U1016 INSERM - UMR8104, CNRS – Université Paris Descartes, PIV Platform
– sequence: 8
  givenname: Isabelle
  surname: Lagoutte
  fullname: Lagoutte, Isabelle
  organization: Institut Cochin, U1016 INSERM - UMR8104, CNRS – Université Paris Descartes, PIV Platform
– sequence: 9
  givenname: Céline
  surname: Bertholle
  fullname: Bertholle, Céline
  organization: Institut Cochin, U1016 INSERM - UMR8104, CNRS – Université Paris Descartes, CYBIO Platform
– sequence: 10
  givenname: Muriel
  surname: Andrieu
  fullname: Andrieu, Muriel
  organization: Institut Cochin, U1016 INSERM - UMR8104, CNRS – Université Paris Descartes, CYBIO Platform
– sequence: 11
  givenname: Sébastien
  surname: Jacques
  fullname: Jacques, Sébastien
  organization: Institut Cochin, U1016 INSERM - UMR8104, CNRS – Université Paris Descartes, Genom’IC Platform, Bâtiment Gustave Roussy
– sequence: 12
  givenname: Céline
  surname: Méhats
  fullname: Méhats, Céline
  organization: Institut Cochin, U1016 INSERM - UMR8104, CNRS – Université Paris Descartes, Team “From Gametes To Birth”
– sequence: 13
  givenname: Daniel
  orcidid: 0000-0002-1915-0717
  surname: Vaiman
  fullname: Vaiman, Daniel
  email: daniel.vaiman@inserm.fr
  organization: Institut Cochin, U1016 INSERM - UMR8104, CNRS – Université Paris Descartes, Team “From Gametes To Birth”
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31417152$$D View this record in MEDLINE/PubMed
https://hal.science/hal-02349183$$DView record in HAL
BookMark eNp9kU1v1DAQhi1UREvbP8ABReICh4A_E_uCVFWlRazUQ4vEzZrYzq6rJF7sZCX-fR3SlrKH-mBbnuedGc_7Fh0MYXAIvSP4M8FMfkmcCCVLTFTJJad1yV6hI4q5KCmj9ODZ_RCdpnSH8xJUcaLeoENGOKmJoEfoxyoM63J0sS8MROvDDpKZOoiF9SlE62Iq_FCMG1fc3F7_IkUfpuTybl1XhLbYRudMB_02eThBr1vokjt9OI_Rz28Xt-dX5er68vv52ao0Fa3Hsm0b01DOlQVlFTOu5lxCzZRTshFguAVJGswtNyxHmoqwCpMKTAUtAcLZMfq65N1OTe-sccMYodPb6HuIf3QAr_-PDH6j12Gnq0oJJllO8GlJsNmTXZ2t9PyGKeOKSLYjmf34UCyG35NLo-59Mq7rYHB5FJrSWlCpqKQZ_bCH3oUpDnkUM8VqxoSYu3__vPun-o-eZIAugIkhpejaJ4RgPXuvF-919l7_9V7PX5J7IuNHGH2YJ-C7l6VskaZcZ1i7-K_tF1T39JnBzw
CitedBy_id crossref_primary_10_1002_cam4_70958
crossref_primary_10_1210_endocr_bqad060
crossref_primary_10_1164_rccm_202202_0325ED
crossref_primary_10_1016_j_placenta_2022_03_009
crossref_primary_10_1111_jcmm_16580
crossref_primary_10_3390_jcm11206048
crossref_primary_10_1016_j_gene_2020_144894
crossref_primary_10_1007_s11906_023_01233_9
crossref_primary_10_26508_lsa_202201517
crossref_primary_10_1007_s11906_020_01039_z
crossref_primary_10_1038_s41598_022_26606_z
crossref_primary_10_1111_aji_13223
crossref_primary_10_1152_ajpheart_00763_2023
crossref_primary_10_1038_s41598_025_07731_x
crossref_primary_10_1016_j_humgen_2023_201193
crossref_primary_10_1038_s41371_021_00637_x
crossref_primary_10_1161_HYPERTENSIONAHA_120_15619
crossref_primary_10_1152_ajpheart_00170_2024
crossref_primary_10_1161_ATVBAHA_124_320737
crossref_primary_10_3389_fcell_2023_1272536
crossref_primary_10_1002_j_2040_4603_2024_tb00304_x
crossref_primary_10_1016_j_ajog_2020_10_025
crossref_primary_10_1016_j_isci_2024_109260
crossref_primary_10_1161_CIRCRESAHA_122_320395
crossref_primary_10_1007_s11906_021_01132_x
Cites_doi 10.1161/01.RES.0000115557.25127.8D
10.1016/S1357-2725(00)00061-3
10.1152/ajpheart.00792.2009
10.1095/biolreprod.112.101147
10.1016/j.ajog.2013.01.042
10.1161/CIRCRESAHA.107.149047
10.1093/cvr/cvr250
10.1016/S0140-6736(10)60279-6
10.1100/tsw.2011.132
10.1111/j.1471-0528.2003.02069.x
10.3389/fimmu.2017.00405
10.1097/CRD.0000000000000021
10.1536/jhj.45.183
10.1161/HYPERTENSIONAHA.114.04971
10.1152/ajpregu.00218.2017
10.1371/journal.pone.0198908
10.1016/j.lfs.2015.10.025
10.1161/HYPERTENSIONAHA.111.172114
10.1016/j.cyto.2013.02.027
10.1073/pnas.0402596101
10.1097/HJH.0000000000001695
10.1136/bmj.323.7323.1213
10.1038/srep19196
10.1128/MCB.00229-15
10.1089/thy.2007.0353
10.1016/s0002-9440(10)63324-x
10.1016/j.neubiorev.2013.03.005
10.1136/heartjnl-2015-308098
10.1007/s11010-018-3359-z
10.1016/j.mvr.2007.04.009
10.1161/01.RES.0000170652.71414.16
10.1038/s41598-019-44639-9
10.1038/sj.jhh.1001785
10.1161/ATVBAHA.107.156059
10.1111/j.1582-4934.2007.00075.x
10.1371/journal.pone.0162487
10.1007/s10554-015-0694-y
10.1038/ng1541
10.1093/hmg/ddq152
10.1089/ars.2013.5661
10.1161/CIRCHEARTFAILURE.110.960625
10.1073/pnas.0336359100
10.1093/ndt/14.5.1129
10.1136/heartjnl-2016-309671
10.1097/HJH.0b013e328360ae6c
10.1016/j.aanat.2017.08.004
10.1093/cvr/cvu018
10.1016/j.ahj.2008.06.042
10.1016/j.preghy.2018.04.015
10.1161/HYPERTENSIONAHA.111.202994
10.1007/s10741-013-9393-8
10.1016/j.matbio.2015.01.023
10.1038/s41420-017-0011-8
10.1161/HYPERTENSIONAHA.111.175919
10.1161/01.HYP.0000143849.67254.ca
10.1096/fj.04-3310fje
10.1097/HJH.0b013e32833a39d0
10.1096/fj.13-238741
10.1016/j.yjmcc.2005.09.003
10.1111/aji.12460
10.1016/j.cjca.2018.11.001
10.4049/jimmunol.161.5.2501
10.1172/jci.insight.120147
10.1038/nature10405
10.1016/j.tcm.2018.11.015
10.1161/JAHA.117.008145
ContentType Journal Article
Copyright The Author(s) 2019
2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Distributed under a Creative Commons Attribution 4.0 International License
Copyright_xml – notice: The Author(s) 2019
– notice: 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Distributed under a Creative Commons Attribution 4.0 International License
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88A
88E
88I
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
7X8
1XC
5PM
DOI 10.1038/s41598-019-48427-3
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Journals
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Science Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
Hyper Article en Ligne (HAL)
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
CrossRef
Publicly Available Content Database

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: PIMPY
  name: ProQuest Publicly Available Content Database
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2045-2322
EndPage 13
ExternalDocumentID PMC6695383
oai:HAL:hal-02349183v1
31417152
10_1038_s41598_019_48427_3
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: INSERM recurrent funding
– fundername: Fondation de France 'Coeur des Femmes'
– fundername: ;
GroupedDBID 0R~
3V.
4.4
53G
5VS
7X7
88A
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AAKDD
ABDBF
ABUWG
ACGFS
ACSMW
ACUHS
ADBBV
ADRAZ
AENEX
AEUYN
AFKRA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
DWQXO
EBD
EBLON
EBS
EJD
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
KQ8
LK8
M0L
M1P
M2P
M48
M7P
M~E
NAO
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RNT
RNTTT
RPM
SNYQT
UKHRP
AASML
AAYXX
AFFHD
AFPKN
CITATION
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
CGR
CUY
CVF
ECM
EIF
NPM
7XB
8FK
K9.
PKEHL
PQEST
PQUKI
PRINS
Q9U
7X8
PUEGO
1XC
IPNFZ
RIG
5PM
ID FETCH-LOGICAL-c627t-ffbcb2449da9d93ce7448a739e98b5ac4da81b04d4c3448b6136016ac6af1a143
IEDL.DBID M7P
ISICitedReferencesCount 31
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000480680800032&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 2045-2322
IngestDate Tue Nov 04 02:00:36 EST 2025
Sat Nov 29 15:10:54 EST 2025
Fri Sep 05 12:32:00 EDT 2025
Tue Oct 07 07:39:20 EDT 2025
Mon Jul 21 06:05:02 EDT 2025
Tue Nov 18 22:36:15 EST 2025
Sat Nov 29 04:38:19 EST 2025
Fri Feb 21 02:40:59 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c627t-ffbcb2449da9d93ce7448a739e98b5ac4da81b04d4c3448b6136016ac6af1a143
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
PMCID: PMC6695383
ORCID 0000-0002-1915-0717
0000-0003-2381-443X
0000-0002-3677-2024
OpenAccessLink https://www.proquest.com/docview/2273733554?pq-origsite=%requestingapplication%
PMID 31417152
PQID 2273733554
PQPubID 2041939
PageCount 13
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_6695383
hal_primary_oai_HAL_hal_02349183v1
proquest_miscellaneous_2275289282
proquest_journals_2273733554
pubmed_primary_31417152
crossref_primary_10_1038_s41598_019_48427_3
crossref_citationtrail_10_1038_s41598_019_48427_3
springer_journals_10_1038_s41598_019_48427_3
PublicationCentury 2000
PublicationDate 2019-08-15
PublicationDateYYYYMMDD 2019-08-15
PublicationDate_xml – month: 08
  year: 2019
  text: 2019-08-15
  day: 15
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Scientific reports
PublicationTitleAbbrev Sci Rep
PublicationTitleAlternate Sci Rep
PublicationYear 2019
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Oka (CR34) 2007; 101
Freeman (CR60) 2004; 44
Chatterjee, Kopriva, Chiasson, Young, Tobin, Newell-Rogers, Mitchell (CR62) 2013; 31
Singh, Ahmed, Girardi (CR65) 2011; 58
CR38
Berry, Cirulli (CR49) 2013; 37
Shahbazian, Shahbazian, Ehsanpour, Aref, Gharibzadeh (CR7) 2011; 5
Dutta, Sengupta (CR66) 2016; 152
Hartman, Frishman (CR54) 2014; 22
Doridot (CR25) 2014; 21
Bytautiene (CR13) 2013; 208
Eghbali (CR27) 2005; 96
Liu, Liu, Shi, Yin, Zhao (CR40) 2018; 4
Wassmann (CR58) 2004; 94
Weissmuller (CR45) 2014; 28
Auger (CR8) 2017; 103
Doridot (CR17) 2013; 61
van Dijk (CR16) 2005; 37
Narizhneva (CR47) 2005; 19
Pritchard, Wick, Slonim, Johnson, Bianchi (CR67) 2012; 87
Levick, Goldspink (CR42) 2014; 19
Chen, Jaffe, Karumanchi (CR1) 2014; 101
Lim (CR48) 1998; 161
Bar (CR6) 1999; 14
CR43
Asahi (CR31) 2004; 101
Kim (CR50) 2011; 92
CR41
Ramsay, Stewart, Greer, Sattar (CR11) 2003; 110
Ducat (CR18) 2016; 6
van Dijk (CR24) 2010; 19
Bautista, Vera, Arenas, Gamarra (CR56) 2005; 19
Cunningham, LaMarca (CR10) 2018; 315
Baird (CR21) 2019; 35
Collinot (CR19) 2018; 36
Cong (CR28) 2015; 31
Pinheiro (CR59) 2013; 62
Steegers, von Dadelszen, Duvekot, Pijnenborg (CR2) 2010; 376
Tang (CR44) 2001; 33
Stan (CR37) 2007; 11
Jarvelainen, Sainio, Wight (CR46) 2015; 43
CR15
Yamamori (CR51) 2005; 39
Su, Lei, Zhang (CR57) 2017; 8
Erlandsson (CR26) 2016; 75
Ichimura (CR35) 2008; 18
Kanda, Takahashi (CR55) 2004; 45
El-Armouche (CR32) 2011; 4
Irgens, Reisaeter, Irgens, Lie (CR4) 2001; 323
Madden (CR36) 2004; 165
Brennan, Morton, Quon, Davidge (CR14) 2016; 11
Palmer (CR23) 2017; 214
Scantlebury (CR29) 2015; 101
Bytautiene (CR12) 2010; 298
Pruthi (CR64) 2015; 65
Ventura (CR22) 2018; 449
Erlandsson (CR20) 2019; 9
Mutter, Karumanchi (CR3) 2008; 75
Bokslag (CR30) 2018; 13
Cosentino (CR52) 2008; 28
Napoli (CR53) 2003; 100
McDonald, Malinowski, Zhou, Yusuf, Devereaux (CR9) 2008; 156
Yan (CR39) 2015; 35
Conway, Doetschman, Azhar (CR33) 2011; 11
Tanz (CR61) 2018; 13
Chatterjee (CR63) 2011; 58
Carty, Delles, Dominiczak (CR5) 2010; 28
A Bokslag (48427_CR30) 2018; 13
CW Chen (48427_CR1) 2014; 101
H Jarvelainen (48427_CR46) 2015; 43
Piyali Chatterjee (48427_CR62) 2013; 31
J Bar (48427_CR6) 1999; 14
NV Narizhneva (48427_CR47) 2005; 19
D Pruthi (48427_CR64) 2015; 65
RC Baird (48427_CR21) 2019; 35
MB Pinheiro (48427_CR59) 2013; 62
L Erlandsson (48427_CR20) 2019; 9
SP Levick (48427_CR42) 2014; 19
48427_CR15
J Cong (48427_CR28) 2015; 31
WP Mutter (48427_CR3) 2008; 75
M Ichimura (48427_CR35) 2008; 18
DJ Freeman (48427_CR60) 2004; 44
C Napoli (48427_CR53) 2003; 100
J Singh (48427_CR65) 2011; 58
JE Ramsay (48427_CR11) 2003; 110
SL Madden (48427_CR36) 2004; 165
F Cosentino (48427_CR52) 2008; 28
RV Stan (48427_CR37) 2007; 11
N Shahbazian (48427_CR7) 2011; 5
YC Lim (48427_CR48) 1998; 161
T Oka (48427_CR34) 2007; 101
S Dutta (48427_CR66) 2016; 152
T Weissmuller (48427_CR45) 2014; 28
L Doridot (48427_CR25) 2014; 21
A Berry (48427_CR49) 2013; 37
OR Palmer (48427_CR23) 2017; 214
S Wassmann (48427_CR58) 2004; 94
N Auger (48427_CR8) 2017; 103
DC Scantlebury (48427_CR29) 2015; 101
T Kanda (48427_CR55) 2004; 45
T Yamamori (48427_CR51) 2005; 39
M Asahi (48427_CR31) 2004; 101
L Erlandsson (48427_CR26) 2016; 75
LE Bautista (48427_CR56) 2005; 19
L Brennan (48427_CR14) 2016; 11
M van Dijk (48427_CR16) 2005; 37
H Collinot (48427_CR19) 2018; 36
BL Tang (48427_CR44) 2001; 33
P Chatterjee (48427_CR63) 2011; 58
J Hartman (48427_CR54) 2014; 22
48427_CR38
LJ Tanz (48427_CR61) 2018; 13
E Bytautiene (48427_CR13) 2013; 208
A El-Armouche (48427_CR32) 2011; 4
CS Kim (48427_CR50) 2011; 92
EA Steegers (48427_CR2) 2010; 376
NM Ventura (48427_CR22) 2018; 449
E Bytautiene (48427_CR12) 2010; 298
A Ducat (48427_CR18) 2016; 6
H Su (48427_CR57) 2017; 8
M Eghbali (48427_CR27) 2005; 96
G Yan (48427_CR39) 2015; 35
S Pritchard (48427_CR67) 2012; 87
MW Cunningham Jr. (48427_CR10) 2018; 315
H Liu (48427_CR40) 2018; 4
M van Dijk (48427_CR24) 2010; 19
48427_CR43
DM Carty (48427_CR5) 2010; 28
L Doridot (48427_CR17) 2013; 61
SJ Conway (48427_CR33) 2011; 11
48427_CR41
SD McDonald (48427_CR9) 2008; 156
HU Irgens (48427_CR4) 2001; 323
References_xml – volume: 94
  start-page: 534
  year: 2004
  end-page: 541
  ident: CR58
  article-title: Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000115557.25127.8D
– volume: 33
  start-page: 33
  year: 2001
  end-page: 44
  ident: CR44
  article-title: ADAMTS: a novel family of extracellular matrix proteases
  publication-title: Int J Biochem Cell Biol
  doi: 10.1016/S1357-2725(00)00061-3
– volume: 298
  start-page: H189
  year: 2010
  end-page: 193
  ident: CR12
  article-title: Long-term maternal cardiovascular function in a mouse model of sFlt-1-induced preeclampsia
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.00792.2009
– volume: 161
  start-page: 2501
  year: 1998
  end-page: 2508
  ident: CR48
  article-title: Important contributions of P-selectin glycoprotein ligand-1-mediated secondary capture to human monocyte adhesion to P-selectin, E-selectin, and TNF-alpha-activated endothelium under flow
  publication-title: J Immunol
– volume: 87
  start-page: 42
  year: 2012
  ident: CR67
  article-title: Comprehensive analysis of genes expressed by rare microchimeric fetal cells in the maternal mouse lung
  publication-title: Biol Reprod
  doi: 10.1095/biolreprod.112.101147
– volume: 208
  start-page: 388 e381
  year: 2013
  end-page: 388 e310
  ident: CR13
  article-title: Long-term alterations in maternal plasma proteome after sFlt1-induced preeclampsia in mice
  publication-title: Am J Obstet Gynecol
  doi: 10.1016/j.ajog.2013.01.042
– volume: 101
  start-page: 313
  year: 2007
  end-page: 321
  ident: CR34
  article-title: Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.107.149047
– volume: 92
  start-page: 466
  year: 2011
  end-page: 475
  ident: CR50
  article-title: Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc
  publication-title: Cardiovasc Res
  doi: 10.1093/cvr/cvr250
– volume: 376
  start-page: 631
  year: 2010
  end-page: 644
  ident: CR2
  article-title: Pre-eclampsia
  publication-title: Lancet (London, England)
  doi: 10.1016/S0140-6736(10)60279-6
– volume: 11
  start-page: 1509
  year: 2011
  end-page: 1524
  ident: CR33
  article-title: The inter-relationship of periostin, TGF beta, and BMP in heart valve development and valvular heart diseases
  publication-title: ScientificWorldJournal
  doi: 10.1100/tsw.2011.132
– volume: 110
  start-page: 1029
  year: 2003
  end-page: 1031
  ident: CR11
  article-title: Microvascular dysfunction: a link between pre-eclampsia and maternal coronary heart disease
  publication-title: BJOG
  doi: 10.1111/j.1471-0528.2003.02069.x
– volume: 8
  start-page: 405
  year: 2017
  ident: CR57
  article-title: Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2017.00405
– volume: 22
  start-page: 147
  year: 2014
  end-page: 151
  ident: CR54
  article-title: Inflammation and atherosclerosis: a review of the role of interleukin-6 in the development of atherosclerosis and the potential for targeted drug therapy
  publication-title: Cardiol Rev
  doi: 10.1097/CRD.0000000000000021
– volume: 45
  start-page: 183
  year: 2004
  end-page: 193
  ident: CR55
  article-title: Interleukin-6 and cardiovascular diseases
  publication-title: Jpn Heart J
  doi: 10.1536/jhj.45.183
– volume: 65
  start-page: 863
  year: 2015
  end-page: 870
  ident: CR64
  article-title: Exposure to experimental preeclampsia in mice enhances the vascular response to future injury
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.114.04971
– volume: 5
  start-page: 324
  year: 2011
  end-page: 327
  ident: CR7
  article-title: Hypertension and microalbuminuria 5 years after pregnancies complicated by pre-eclampsia
  publication-title: Iran J Kidney Dis
– volume: 315
  start-page: R521
  year: 2018
  end-page: R528
  ident: CR10
  article-title: Risk of cardiovascular disease, end-stage renal disease, and stroke in postpartum women and their fetuses after a hypertensive pregnancy
  publication-title: Am J Physiol Regul Integr Comp Physiol
  doi: 10.1152/ajpregu.00218.2017
– volume: 13
  start-page: e0198908
  year: 2018
  ident: CR30
  article-title: Early-onset preeclampsia predisposes to preclinical diastolic left ventricular dysfunction in the fifth decade of life: An observational study
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0198908
– volume: 152
  start-page: 244
  year: 2016
  end-page: 248
  ident: CR66
  article-title: Men and mice: Relating their ages
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2015.10.025
– volume: 58
  start-page: 489
  year: 2011
  end-page: 496
  ident: CR63
  article-title: Interleukin 10 deficiency exacerbates toll-like receptor 3-induced preeclampsia-like symptoms in mice
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.111.172114
– volume: 62
  start-page: 165
  year: 2013
  end-page: 173
  ident: CR59
  article-title: Severe preeclampsia goes along with a cytokine network disturbance towards a systemic inflammatory state
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2013.02.027
– ident: CR15
– volume: 101
  start-page: 9199
  year: 2004
  end-page: 9204
  ident: CR31
  article-title: Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0402596101
– volume: 36
  start-page: 1399
  year: 2018
  end-page: 1406
  ident: CR19
  article-title: Preeclampsia induced by STOX1 overexpression in mice induces intrauterine growth restriction, abnormal ultrasonography and BOLD MRI signatures
  publication-title: J Hypertens
  doi: 10.1097/HJH.0000000000001695
– volume: 323
  start-page: 1213
  year: 2001
  end-page: 1217
  ident: CR4
  article-title: Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study
  publication-title: BMJ (Clinical research ed
  doi: 10.1136/bmj.323.7323.1213
– volume: 6
  year: 2016
  ident: CR18
  article-title: Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsia
  publication-title: Sci Rep
  doi: 10.1038/srep19196
– volume: 35
  start-page: 3312
  year: 2015
  end-page: 3323
  ident: CR39
  article-title: Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00229-15
– volume: 18
  start-page: 625
  year: 2008
  end-page: 630
  ident: CR35
  article-title: Associations of protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene polymorphisms with susceptibility to Graves’ disease in a Japanese population
  publication-title: Thyroid
  doi: 10.1089/thy.2007.0353
– volume: 165
  start-page: 601
  year: 2004
  end-page: 608
  ident: CR36
  article-title: Vascular gene expression in nonneoplastic and malignant brain
  publication-title: Am J Pathol
  doi: 10.1016/s0002-9440(10)63324-x
– volume: 37
  start-page: 790
  year: 2013
  end-page: 802
  ident: CR49
  article-title: The p66(Shc) gene paves the way for healthspan: evolutionary and mechanistic perspectives
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/j.neubiorev.2013.03.005
– volume: 101
  start-page: 1584
  year: 2015
  end-page: 1590
  ident: CR29
  article-title: Left ventricular hypertrophy after hypertensive pregnancy disorders
  publication-title: Heart
  doi: 10.1136/heartjnl-2015-308098
– volume: 449
  start-page: 227
  year: 2018
  end-page: 236
  ident: CR22
  article-title: Developmental origins of pregnancy-induced cardiac changes: establishment of a novel model using the atrial natriuretic peptide gene-disrupted mice
  publication-title: Mol Cell Biochem
  doi: 10.1007/s11010-018-3359-z
– volume: 75
  start-page: 1
  year: 2008
  end-page: 8
  ident: CR3
  article-title: Molecular mechanisms of preeclampsia
  publication-title: Microvasc Res
  doi: 10.1016/j.mvr.2007.04.009
– volume: 96
  start-page: 1208
  year: 2005
  end-page: 1216
  ident: CR27
  article-title: Molecular and functional signature of heart hypertrophy during pregnancy
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000170652.71414.16
– volume: 9
  year: 2019
  ident: CR20
  article-title: Alpha-1 microglobulin as a potential therapeutic candidate for treatment of hypertension and oxidative stress in the STOX1 preeclampsia mouse model
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-44639-9
– ident: CR43
– volume: 19
  start-page: 149
  year: 2005
  end-page: 154
  ident: CR56
  article-title: Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-alpha) and essential hypertension
  publication-title: J Hum Hypertens
  doi: 10.1038/sj.jhh.1001785
– volume: 28
  start-page: 622
  year: 2008
  end-page: 628
  ident: CR52
  article-title: Final common molecular pathways of aging and cardiovascular disease: role of the p66Shc protein
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/ATVBAHA.107.156059
– volume: 11
  start-page: 621
  year: 2007
  end-page: 643
  ident: CR37
  article-title: Endothelial stomatal and fenestral diaphragms in normal vessels and angiogenesis
  publication-title: J Cell Mol Med
  doi: 10.1111/j.1582-4934.2007.00075.x
– volume: 11
  start-page: e0162487
  year: 2016
  ident: CR14
  article-title: Postpartum Vascular Dysfunction in the Reduced Uteroplacental Perfusion Model of Preeclampsia
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0162487
– volume: 31
  start-page: 1361
  year: 2015
  end-page: 1368
  ident: CR28
  article-title: Maternal cardiac remodeling and dysfunction in preeclampsia: a three-dimensional speckle-tracking echocardiography study
  publication-title: Int J Cardiovasc Imaging
  doi: 10.1007/s10554-015-0694-y
– volume: 37
  start-page: 514
  year: 2005
  end-page: 519
  ident: CR16
  article-title: Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family
  publication-title: Nat Genet
  doi: 10.1038/ng1541
– volume: 19
  start-page: 2658
  year: 2010
  end-page: 2667
  ident: CR24
  article-title: The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddq152
– volume: 21
  start-page: 819
  year: 2014
  end-page: 834
  ident: CR25
  article-title: Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2013.5661
– volume: 4
  start-page: 621
  year: 2011
  end-page: 627
  ident: CR32
  article-title: Follistatin-like 1 in chronic systolic heart failure: a marker of left ventricular remodeling
  publication-title: Circ Heart Fail
  doi: 10.1161/CIRCHEARTFAILURE.110.960625
– volume: 100
  start-page: 2112
  year: 2003
  end-page: 2116
  ident: CR53
  article-title: Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0336359100
– volume: 14
  start-page: 1129
  year: 1999
  end-page: 1132
  ident: CR6
  article-title: Microalbuminuria after pregnancy complicated by pre-eclampsia
  publication-title: Nephrol Dial Transplant
  doi: 10.1093/ndt/14.5.1129
– volume: 103
  start-page: 235
  year: 2017
  end-page: 243
  ident: CR8
  article-title: Recurrent pre-eclampsia and subsequent cardiovascular risk
  publication-title: Heart
  doi: 10.1136/heartjnl-2016-309671
– volume: 31
  start-page: 1414
  issue: 7
  year: 2013
  end-page: 1423
  ident: CR62
  article-title: Interleukin-4 deficiency induces mild preeclampsia in mice
  publication-title: Journal of Hypertension
  doi: 10.1097/HJH.0b013e328360ae6c
– volume: 214
  start-page: 43
  year: 2017
  end-page: 52
  ident: CR23
  article-title: characterization of the murine venous system before and during dobutamine stimulation: implications for preclinical models of venous disease
  publication-title: Ann Anat
  doi: 10.1016/j.aanat.2017.08.004
– volume: 101
  start-page: 579
  year: 2014
  end-page: 586
  ident: CR1
  article-title: Pre-eclampsia and cardiovascular disease
  publication-title: Cardiovasc Res
  doi: 10.1093/cvr/cvu018
– volume: 156
  start-page: 918
  year: 2008
  end-page: 930
  ident: CR9
  article-title: Cardiovascular sequelae of preeclampsia/eclampsia: a systematic review and meta-analyses
  publication-title: Am Heart J
  doi: 10.1016/j.ahj.2008.06.042
– volume: 13
  start-page: 14
  year: 2018
  end-page: 21
  ident: CR61
  article-title: Cardiovascular biomarkers in the years following pregnancies complicated by hypertensive disorders or delivered preterm
  publication-title: Pregnancy Hypertens
  doi: 10.1016/j.preghy.2018.04.015
– volume: 61
  start-page: 662
  year: 2013
  end-page: 668
  ident: CR17
  article-title: Preeclampsia-like symptoms induced in mice by fetoplacental expression of STOX1 are reversed by aspirin treatment
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.111.202994
– ident: CR38
– volume: 19
  start-page: 227
  year: 2014
  end-page: 236
  ident: CR42
  article-title: Could interferon-gamma be a therapeutic target for treating heart failure?
  publication-title: Heart Fail Rev
  doi: 10.1007/s10741-013-9393-8
– volume: 43
  start-page: 15
  year: 2015
  end-page: 26
  ident: CR46
  article-title: Pivotal role for decorin in angiogenesis
  publication-title: Matrix Biol
  doi: 10.1016/j.matbio.2015.01.023
– volume: 4
  start-page: 27
  year: 2018
  ident: CR40
  article-title: NR4A2 protects cardiomyocytes against myocardial infarction injury by promoting autophagy
  publication-title: Cell Death Discov
  doi: 10.1038/s41420-017-0011-8
– volume: 58
  start-page: 716
  year: 2011
  end-page: 724
  ident: CR65
  article-title: Role of complement component C1q in the onset of preeclampsia in mice
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.111.175919
– volume: 44
  start-page: 708
  year: 2004
  end-page: 714
  ident: CR60
  article-title: Short- and long-term changes in plasma inflammatory markers associated with preeclampsia
  publication-title: Hypertension
  doi: 10.1161/01.HYP.0000143849.67254.ca
– volume: 19
  start-page: 1158
  year: 2005
  end-page: 1160
  ident: CR47
  article-title: Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium
  publication-title: FASEB J
  doi: 10.1096/fj.04-3310fje
– volume: 28
  start-page: 1349
  year: 2010
  end-page: 1355
  ident: CR5
  article-title: Preeclampsia and future maternal health
  publication-title: J Hypertens
  doi: 10.1097/HJH.0b013e32833a39d0
– volume: 28
  start-page: 256
  year: 2014
  end-page: 264
  ident: CR45
  article-title: HIF-dependent regulation of AKAP12 (gravin) in the control of human vascular endothelial function
  publication-title: FASEB J
  doi: 10.1096/fj.13-238741
– ident: CR41
– volume: 39
  start-page: 992
  year: 2005
  end-page: 995
  ident: CR51
  article-title: P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction
  publication-title: J Mol Cell Cardiol
  doi: 10.1016/j.yjmcc.2005.09.003
– volume: 75
  start-page: 402
  year: 2016
  end-page: 410
  ident: CR26
  article-title: Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities
  publication-title: Am J Reprod Immunol
  doi: 10.1111/aji.12460
– volume: 35
  start-page: 68
  year: 2019
  end-page: 76
  ident: CR21
  article-title: Pregnancy-Associated Cardiac Hypertrophy in Corin-Deficient Mice: Observations in a Transgenic Model of Preeclampsia
  publication-title: Can J Cardiol
  doi: 10.1016/j.cjca.2018.11.001
– volume: 214
  start-page: 43
  year: 2017
  ident: 48427_CR23
  publication-title: Ann Anat
  doi: 10.1016/j.aanat.2017.08.004
– volume: 36
  start-page: 1399
  year: 2018
  ident: 48427_CR19
  publication-title: J Hypertens
  doi: 10.1097/HJH.0000000000001695
– volume: 161
  start-page: 2501
  year: 1998
  ident: 48427_CR48
  publication-title: J Immunol
  doi: 10.4049/jimmunol.161.5.2501
– volume: 110
  start-page: 1029
  year: 2003
  ident: 48427_CR11
  publication-title: BJOG
  doi: 10.1111/j.1471-0528.2003.02069.x
– volume: 35
  start-page: 3312
  year: 2015
  ident: 48427_CR39
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00229-15
– volume: 208
  start-page: 388 e381
  year: 2013
  ident: 48427_CR13
  publication-title: Am J Obstet Gynecol
  doi: 10.1016/j.ajog.2013.01.042
– volume: 100
  start-page: 2112
  year: 2003
  ident: 48427_CR53
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0336359100
– volume: 13
  start-page: 14
  year: 2018
  ident: 48427_CR61
  publication-title: Pregnancy Hypertens
  doi: 10.1016/j.preghy.2018.04.015
– volume: 298
  start-page: H189
  year: 2010
  ident: 48427_CR12
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.00792.2009
– volume: 75
  start-page: 402
  year: 2016
  ident: 48427_CR26
  publication-title: Am J Reprod Immunol
  doi: 10.1111/aji.12460
– volume: 11
  start-page: 1509
  year: 2011
  ident: 48427_CR33
  publication-title: ScientificWorldJournal
  doi: 10.1100/tsw.2011.132
– volume: 28
  start-page: 622
  year: 2008
  ident: 48427_CR52
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/ATVBAHA.107.156059
– volume: 31
  start-page: 1361
  year: 2015
  ident: 48427_CR28
  publication-title: Int J Cardiovasc Imaging
  doi: 10.1007/s10554-015-0694-y
– volume: 101
  start-page: 9199
  year: 2004
  ident: 48427_CR31
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0402596101
– volume: 4
  start-page: 27
  year: 2018
  ident: 48427_CR40
  publication-title: Cell Death Discov
  doi: 10.1038/s41420-017-0011-8
– volume: 19
  start-page: 1158
  year: 2005
  ident: 48427_CR47
  publication-title: FASEB J
  doi: 10.1096/fj.04-3310fje
– volume: 323
  start-page: 1213
  year: 2001
  ident: 48427_CR4
  publication-title: BMJ (Clinical research ed
  doi: 10.1136/bmj.323.7323.1213
– volume: 14
  start-page: 1129
  year: 1999
  ident: 48427_CR6
  publication-title: Nephrol Dial Transplant
  doi: 10.1093/ndt/14.5.1129
– volume: 43
  start-page: 15
  year: 2015
  ident: 48427_CR46
  publication-title: Matrix Biol
  doi: 10.1016/j.matbio.2015.01.023
– volume: 58
  start-page: 716
  year: 2011
  ident: 48427_CR65
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.111.175919
– volume: 65
  start-page: 863
  year: 2015
  ident: 48427_CR64
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.114.04971
– volume: 87
  start-page: 42
  year: 2012
  ident: 48427_CR67
  publication-title: Biol Reprod
  doi: 10.1095/biolreprod.112.101147
– volume: 33
  start-page: 33
  year: 2001
  ident: 48427_CR44
  publication-title: Int J Biochem Cell Biol
  doi: 10.1016/S1357-2725(00)00061-3
– volume: 19
  start-page: 2658
  year: 2010
  ident: 48427_CR24
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddq152
– volume: 101
  start-page: 579
  year: 2014
  ident: 48427_CR1
  publication-title: Cardiovasc Res
  doi: 10.1093/cvr/cvu018
– volume: 39
  start-page: 992
  year: 2005
  ident: 48427_CR51
  publication-title: J Mol Cell Cardiol
  doi: 10.1016/j.yjmcc.2005.09.003
– volume: 376
  start-page: 631
  year: 2010
  ident: 48427_CR2
  publication-title: Lancet (London, England)
  doi: 10.1016/S0140-6736(10)60279-6
– volume: 4
  start-page: 621
  year: 2011
  ident: 48427_CR32
  publication-title: Circ Heart Fail
  doi: 10.1161/CIRCHEARTFAILURE.110.960625
– volume: 22
  start-page: 147
  year: 2014
  ident: 48427_CR54
  publication-title: Cardiol Rev
  doi: 10.1097/CRD.0000000000000021
– volume: 61
  start-page: 662
  year: 2013
  ident: 48427_CR17
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.111.202994
– ident: 48427_CR15
  doi: 10.1172/jci.insight.120147
– volume: 18
  start-page: 625
  year: 2008
  ident: 48427_CR35
  publication-title: Thyroid
  doi: 10.1089/thy.2007.0353
– volume: 11
  start-page: e0162487
  year: 2016
  ident: 48427_CR14
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0162487
– volume: 62
  start-page: 165
  year: 2013
  ident: 48427_CR59
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2013.02.027
– volume: 96
  start-page: 1208
  year: 2005
  ident: 48427_CR27
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000170652.71414.16
– volume: 8
  start-page: 405
  year: 2017
  ident: 48427_CR57
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2017.00405
– volume: 19
  start-page: 227
  year: 2014
  ident: 48427_CR42
  publication-title: Heart Fail Rev
  doi: 10.1007/s10741-013-9393-8
– volume: 35
  start-page: 68
  year: 2019
  ident: 48427_CR21
  publication-title: Can J Cardiol
  doi: 10.1016/j.cjca.2018.11.001
– volume: 92
  start-page: 466
  year: 2011
  ident: 48427_CR50
  publication-title: Cardiovasc Res
  doi: 10.1093/cvr/cvr250
– volume: 13
  start-page: e0198908
  year: 2018
  ident: 48427_CR30
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0198908
– volume: 156
  start-page: 918
  year: 2008
  ident: 48427_CR9
  publication-title: Am Heart J
  doi: 10.1016/j.ahj.2008.06.042
– volume: 75
  start-page: 1
  year: 2008
  ident: 48427_CR3
  publication-title: Microvasc Res
  doi: 10.1016/j.mvr.2007.04.009
– volume: 6
  year: 2016
  ident: 48427_CR18
  publication-title: Sci Rep
  doi: 10.1038/srep19196
– volume: 45
  start-page: 183
  year: 2004
  ident: 48427_CR55
  publication-title: Jpn Heart J
  doi: 10.1536/jhj.45.183
– volume: 152
  start-page: 244
  year: 2016
  ident: 48427_CR66
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2015.10.025
– volume: 28
  start-page: 1349
  year: 2010
  ident: 48427_CR5
  publication-title: J Hypertens
  doi: 10.1097/HJH.0b013e32833a39d0
– volume: 5
  start-page: 324
  year: 2011
  ident: 48427_CR7
  publication-title: Iran J Kidney Dis
– volume: 315
  start-page: R521
  year: 2018
  ident: 48427_CR10
  publication-title: Am J Physiol Regul Integr Comp Physiol
  doi: 10.1152/ajpregu.00218.2017
– volume: 28
  start-page: 256
  year: 2014
  ident: 48427_CR45
  publication-title: FASEB J
  doi: 10.1096/fj.13-238741
– volume: 31
  start-page: 1414
  issue: 7
  year: 2013
  ident: 48427_CR62
  publication-title: Journal of Hypertension
  doi: 10.1097/HJH.0b013e328360ae6c
– volume: 165
  start-page: 601
  year: 2004
  ident: 48427_CR36
  publication-title: Am J Pathol
  doi: 10.1016/s0002-9440(10)63324-x
– volume: 103
  start-page: 235
  year: 2017
  ident: 48427_CR8
  publication-title: Heart
  doi: 10.1136/heartjnl-2016-309671
– volume: 21
  start-page: 819
  year: 2014
  ident: 48427_CR25
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2013.5661
– ident: 48427_CR41
  doi: 10.1038/nature10405
– volume: 19
  start-page: 149
  year: 2005
  ident: 48427_CR56
  publication-title: J Hum Hypertens
  doi: 10.1038/sj.jhh.1001785
– volume: 9
  year: 2019
  ident: 48427_CR20
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-44639-9
– volume: 94
  start-page: 534
  year: 2004
  ident: 48427_CR58
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000115557.25127.8D
– volume: 58
  start-page: 489
  year: 2011
  ident: 48427_CR63
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.111.172114
– volume: 37
  start-page: 514
  year: 2005
  ident: 48427_CR16
  publication-title: Nat Genet
  doi: 10.1038/ng1541
– ident: 48427_CR38
  doi: 10.1016/j.tcm.2018.11.015
– volume: 44
  start-page: 708
  year: 2004
  ident: 48427_CR60
  publication-title: Hypertension
  doi: 10.1161/01.HYP.0000143849.67254.ca
– volume: 449
  start-page: 227
  year: 2018
  ident: 48427_CR22
  publication-title: Mol Cell Biochem
  doi: 10.1007/s11010-018-3359-z
– volume: 101
  start-page: 1584
  year: 2015
  ident: 48427_CR29
  publication-title: Heart
  doi: 10.1136/heartjnl-2015-308098
– volume: 37
  start-page: 790
  year: 2013
  ident: 48427_CR49
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/j.neubiorev.2013.03.005
– ident: 48427_CR43
  doi: 10.1161/JAHA.117.008145
– volume: 101
  start-page: 313
  year: 2007
  ident: 48427_CR34
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.107.149047
– volume: 11
  start-page: 621
  year: 2007
  ident: 48427_CR37
  publication-title: J Cell Mol Med
  doi: 10.1111/j.1582-4934.2007.00075.x
SSID ssj0000529419
Score 2.426109
Snippet Adverse long-term cardiovascular (CV) consequences of PE are well established in women. However, the mechanism responsible for that risk remains unknown. Here,...
SourceID pubmedcentral
hal
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 11918
SubjectTerms 45/61
59
631/443/592/1540
631/443/592/75/243/793
64/60
Animals
Body Weight
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnostic imaging
Cardiovascular Diseases - etiology
Cardiovascular Diseases - genetics
Cardiovascular system
Carrier Proteins - metabolism
Cellular stress response
Chemokines
CXCL11 protein
CXCL13 protein
CXCL16 protein
Cytokines - metabolism
Deregulation
Disease Models, Animal
Doppler effect
Endothelial cells
Endothelial Cells - metabolism
Female
Females
Fibrosis
Gene Expression Regulation
Heart
Histology
Humanities and Social Sciences
Hypertrophy
Interleukin 10
Interleukin 16
Interleukin 2
Interleukin 4
Interleukin 6
Life Sciences
multidisciplinary
Myocardium - pathology
Organ Size
Pre-eclampsia
Pre-Eclampsia - blood
Pre-Eclampsia - pathology
Preeclampsia
Pregnancy
Reproductive Biology
Rodents
Science
Science (multidisciplinary)
Transcription, Genetic
Ultrasonic imaging
Ultrasound
Ventricle
Title Long-term cardiovascular disorders in the STOX1 mouse model of preeclampsia
URI https://link.springer.com/article/10.1038/s41598-019-48427-3
https://www.ncbi.nlm.nih.gov/pubmed/31417152
https://www.proquest.com/docview/2273733554
https://www.proquest.com/docview/2275289282
https://hal.science/hal-02349183
https://pubmed.ncbi.nlm.nih.gov/PMC6695383
Volume 9
WOSCitedRecordID wos000480680800032&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: DOA
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: M~E
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: M7P
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: 7X7
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: BENPR
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Publicly Available Content Database
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: PIMPY
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Science Database
  customDbUrl:
  eissn: 2045-2322
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000529419
  issn: 2045-2322
  databaseCode: M2P
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/sciencejournals
  providerName: ProQuest
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwED_RDSRe-B4LjMog3sBak7hx_IQG2jTEViIYUnmKHH-wSijtmjKJ_547J81UJvbCSx5iR7F9d76f7853AK8Ro6PaiT2X1iZcqKTiWriMSwTjlTcGyS5CsQk5meTTqSo6g1vThVWu98SwUdu5IRv5foJ6VqakHd8tLjhVjSLvaldCYwDblCUhDaF7RW9jIS-WiFV3V2aU5vsN6iu6UxYrLnKRoHxt6KPBOUVDXoea1yMm_3KbBm10dP9_5_EA7nU4lB20jPMQbrn6EdxpK1P-fgyfTub1D07bNjMbEavMduk6GzarGaJH9vXs8zRmZEFwLNTVYXPPFkvnDDLbopnpJ_Dt6PDswzHv6i5wkyVyxb2vTIVqX1mtrEqNk0hQLVPlVF6NtRFWI9gdCStMii0VIgJK6qJNpn2sEYDtwFY9r90uMFXpkUSEaUbGCu117itEPD721mTkSo4gXq9-abqk5FQb42cZnONpXrYUK5FiZaBYmUbwpv9m0abkuLH3KyRq35GyaR8fnJT0DuGKULilXcYR7K2JVXYy3JRXlIrgZd-M0kcuFV07XFfqM8YjK55bI3jaskj_K-TyWCI8ikBuMM_GWDZb6tl5yPCdZQoVEY797ZrNrob176k-u3kWz-FuQoxP-XzHe7C1Wv5yL-C2uVzNmuUQBnIqwzMfwvb7w0nxZRgMFPg8TYphkCxsKT6eFt__ABM8Jc4
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1LbxMxEB61BQQXnqUsFDAITtRqdtdZrw8IVUCVKiFUIki5Ga8fbSS0Cdm0Vf8Uv5HxvqqlorceuK6drL3-ZuazZzwD8AY5Opqd0FFuTESZiDKqmE0oRzKeOa1x2VlZbIKPx-l0Kg7X4HdzF8aHVTY6sVTUZq79GfluhHaWx946flj8or5qlPeuNiU0KlgM7fkZbtmK9wefcH3fRtH-58nHAa2rClCdRHxFnct0hkZNGCWMiLXlOFzFY2FFmvWVZkYhlesxw3SMLRnaO5-yROlEuVAhvcD_XYcbSCOitAwVPGzPdLzXjIWivpvTi9PdAu2jv8MWCspSFqE8d-zf-rGPvrxMbS9HaP7lpi2t3_69_-273Ye7Nc8me5VgPIA1mz-EW1XlzfNHMBzN8yPqzRLRnYhcYup0pAWZ5QTZMfk2-ToNiT8hsaSsG0TmjiyW1moUpkUxU5vw_Vpm8hg28nlunwARmepxZNC6pw1TTqUuQ0bnQmd04l3lAYTNaktdJ133tT9-ytL5H6eyQohEhMgSITIO4F37m0WVcuTK3q8RRG1Hny18sDeS_hnSMSZQZZ-GAWw34JC1jirkBTICeNU2o3bxLiOVW_yuvk8ft-S4Lw9gq4Jk-yqU4pAj_QuAd8DaGUu3JZ8dlxnMk0SgocWx7zSwvhjWv6f69OpZvITbg8mXkRwdjIfP4E7khc7nLu5vw8ZqeWKfw019upoVyxel1BL4cd1w_wPVv3yF
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1LbxMxEB615SEuvB8LBQyCE1jJ7jrr9QGhihK1ShQiUaTcjNdr00hoE7KhqH-NX8fMvqpQ0VsPXNdO1l5_M_PZM54BeIUcHc1O6LnM84gLFWXcCJdwiWQ889bisouq2IScTNLZTE234Hd7F4bCKludWCnqfGHpjLwXoZ2VMVnHnm_CIqb7w_fLH5wqSJGntS2nUUNk5E5_4fatfHe4j2v9OoqGH48-HPCmwgC3SSTX3PvMZmjgVG5UrmLrJA7dyFg5lWYDY0VukNb1RS5sjC0Z2j5KX2JsYnxokGrg_27DFUlJy6uwwWl3vkMeNBGq5p5OP057JdpKus8WKi5SEaFsb9jC7WOKxDxPc89Ha_7lsq0s4fDW__wNb8PNhn-zvVpg7sCWK-7Ctboi5-k9GI0XxTdO5orZjUhdljdpSks2LxiyZvb56NMsZHRy4lhVT4gtPFuunLMoZMtybu7Dl0uZyQPYKRaFewRMZaYvkVnbvs2F8Sb1GTI9H_rcJuRCDyBsV17bJhk71QT5rquggDjVNVo0okVXaNFxAG-63yzrVCQX9n6JgOo6Uhbxg72xpmdI04RCVX4SBrDbAkU3uqvUZygJ4EXXjFqHXEmmcPhdqc8At-q4Xw_gYQ3P7lUo3aFEWhiA3ADuxlg2W4r5cZXZPEkUGmAc-9sW4mfD-vdUH188i-dwHVGux4eT0RO4EZH8UUrjwS7srFc_3VO4ak_W83L1rBJgBl8vG-1_AD6MhUI
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Long-term+cardiovascular+disorders+in+the+STOX1+mouse+model+of+preeclampsia&rft.jtitle=Scientific+reports&rft.au=Miralles%2C+Francisco&rft.au=Collinot%2C+H%C3%A9l%C3%A8ne&rft.au=Boumerdassi%2C+Yasmine&rft.au=Ducat%2C+Aur%C3%A9lien&rft.date=2019-08-15&rft.eissn=2045-2322&rft.volume=9&rft.issue=1&rft.spage=11918&rft_id=info:doi/10.1038%2Fs41598-019-48427-3&rft_id=info%3Apmid%2F31417152&rft.externalDocID=31417152
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon