Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study

•Thalamus atrophy is associated with cognitive impairment in multiple sclerosis.•This was confirmed by automated and manual segmentations, but effect sizes varied.•The algorithms work in a multi-center setting.•Automated techniques exhibit proportional bias with respect to thalamus size.•Differences...

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Bibliographic Details
Published in:	NeuroImage clinical Vol. 29; p. 102549
Main Authors:	Burggraaff, Jessica, Liu, Yao, Prieto, Juan C., Simoes, Jorge, de Sitter, Alexandra, Ruggieri, Serena, Brouwer, Iman, Lissenberg-Witte, Birgit I., Rocca, Mara A., Valsasina, Paola, Ropele, Stefan, Gasperini, Claudio, Gallo, Antonio, Pareto, Deborah, Sastre-Garriga, Jaume, Enzinger, Christian, Filippi, Massimo, De Stefano, Nicola, Ciccarelli, Olga, Hulst, Hanneke E., Wattjes, Mike P., Barkhof, Frederik, Uitdehaag, Bernard M.J., Vrenken, Hugo, Guttmann, Charles R.G.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01.01.2021 Elsevier
Subjects:	Atrophy Cognition Deep grey matter MRI Multiple Sclerosis Radiology Regular Segmentation Thalamus RRMS WMV Segmentation MRI WCST CNR NGMV SPM12 Cognition IPS Multiple Sclerosis Atrophy SD eTIV WLG SRT NWMV WM VolBrain Thalamus CAT12 Deep grey matter SDMT EDSS CII NBV GIF CI GM MS ICC CP 10/36 SRT GMV PASAT FSL-FIRST BRB-N HC Statistical Parametric Mapping 12 Normalized brain volume Computational Anatomy Toolbox for Statistical Parametric Mapping 12 Normalized grey matter volume Selective Reminding Test standard deviations 10/36 Spatial Recall Test intraclass correlation coefficient cognitively preserved Brief Repeatable Battery of Neuropsychological Tests white matter volume Paced Auditory Serial Addition Test FMRIB Integrated Registration and Segmentation Tool information processing speed healthy control contrast-to-noise ratio Geodesic Information Flows estimated total intracranial volume Expanded Disability Status Scale cognitive impairment index Normalized white matter volume white matter grey matter volume grey matter Word List Generation cognitively impaired and preserved (CP) MRI Brain Volumetry System Relapsing-Remitting Multiple Sclerosis Wisconsin Card Sorting Test Symbol Digit Modalities Test
ISSN:	2213-1582, 2213-1582
Online Access:	Get full text
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