Targeting NOX enzymes in the central nervous system: therapeutic opportunities

Among the pathogenic mechanisms underlying central nervous system (CNS) diseases, oxidative stress is almost invariably described. For this reason, numerous attempts have been made to decrease reactive oxygen species (ROS) with the administration of antioxidants as potential therapies for CNS disord...

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Bibliographic Details
Published in:	Cellular and molecular life sciences : CMLS Vol. 69; no. 14; pp. 2387 - 2407
Main Authors:	Sorce, Silvia, Krause, Karl-Heinz, Jaquet, Vincent
Format:	Journal Article
Language:	English
Published:	Basel Springer-Verlag 01.07.2012 SP Birkhäuser Verlag Basel Springer Nature B.V
Subjects:	Alzheimer disease Alzheimer's disease Amyotrophic lateral sclerosis Antioxidants Autoimmune diseases Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Central nervous system Central Nervous System Diseases - enzymology Central Nervous System Diseases - pathology Central Nervous System Diseases - therapy Clinical trials Demyelinating diseases Demyelination diseases Disorders drugs Enzyme Inhibitors - therapeutic use Enzymes Humans Immune response Immunosuppressive agents Life Sciences Mental disorders Movement disorders Multi-Author Review NAD(P)H oxidase NAD(P)H oxidase (H2O2-forming) NADP (coenzyme) NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - metabolism Neurodegenerative diseases Neurological disorders Oxidative stress Oxygen Parkinson disease Parkinson's disease Pathology Protein Isoforms - antagonists & inhibitors Protein Isoforms - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Schizophrenia Small Molecule Libraries - chemical synthesis Small Molecule Libraries - chemistry Small Molecule Libraries - therapeutic use stroke therapeutics Antioxidants NOX inhibitors Oxidative stress Brain Stroke NOX NADPH oxidase Central nervous system Schizophrenia Autoimmune diseases Alzheimer Parkinson
ISSN:	1420-682X, 1420-9071, 1420-9071
Online Access:	Get full text
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