MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

Circulating microRNAs (miRNA) are relatively stable in plasma and are a new class of disease biomarkers. Here we present evidence that high-density lipoprotein (HDL) transports endogenous miRNAs and delivers them to recipient cells with functional targeting capabilities. Cellular export of miRNAs to...

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Veröffentlicht in:	Nature cell biology Jg. 13; H. 4; S. 423 - 433
Hauptverfasser:	Vickers, Kasey C., Palmisano, Brian T., Shoucri, Bassem M., Shamburek, Robert D., Remaley, Alan T.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.04.2011 Nature Publishing Group
Schlagworte:	631/337/384/331 631/61/2300 Animals Apolipoproteins E - genetics Apolipoproteins E - metabolism Atherosclerosis - blood Atherosclerosis - genetics Biological Transport - physiology Biomarkers Biomarkers - blood Biomedical and Life Sciences Cancer Research Care and treatment CD36 Antigens - genetics CD36 Antigens - metabolism Cell Biology Chromatography Communication Developmental Biology Diagnosis Gene expression Gene Expression Regulation High density lipoprotein High density lipoproteins Humans Hypercholesterolemia Hyperlipoproteinemia Type II - blood Hyperlipoproteinemia Type II - genetics Life Sciences Lipoproteins Lipoproteins, HDL - blood Mice Mice, Knockout MicroRNA MicroRNAs MicroRNAs - blood Physiological aspects Plasma Proteins Receptors, LDL - genetics Receptors, LDL - metabolism Stem Cells United States
ISSN:	1465-7392, 1476-4679, 1476-4679
Online-Zugang:	Volltext
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