Confidence from uncertainty - A multi-target drug screening method from robust control theory

Background Robustness is a recognized feature of biological systems that evolved as a defence to environmental variability. Complex diseases such as diabetes, cancer, bacterial and viral infections, exploit the same mechanisms that allow for robust behaviour in healthy conditions to ensure their own...

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Bibliographic Details
Published in:	BMC systems biology Vol. 4; no. 1; p. 161
Main Authors:	Luni, Camilla, Shoemaker, Jason E, Sanft, Kevin R, Petzold, Linda R, Doyle, Francis J
Format:	Journal Article
Language:	English
Published:	London BioMed Central 24.11.2010 BioMed Central Ltd
Subjects:	Algorithms Antibiotics Behavior Bioinformatics Biomedical and Life Sciences Cellular and Medical Topics Computational Biology/Bioinformatics Computer science Confidence Diabetes Drug Evaluation, Preclinical - methods Drug therapy Feedback, Physiological Genes Health aspects Life Sciences Mandatory drug testing Methodology Methodology Article Methods Models, Biological Ordinary differential equations Physiological Physiological aspects Signal transduction Simulation and Modeling Studies Systems Biology Systems Biology - methods Uncertainty United States Stochastic Simulation Algorithm Robust Performance System Biology Markup Language Nominal Performance Local Sensitivity Analysis
ISSN:	1752-0509, 1752-0509
Online Access:	Get full text
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