Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination

•222-nm UVC light (0.1 mW/cm2) reduced viable SARS-CoV-2 by 0.94 log10 in 10 seconds.•222-nm UVC light (0.1 mW/cm2) reduced viable SARS-CoV-2 by 2.51 log10 in 30 seconds.•222-nm UVC light did not reduce SARS-CoV-2 RNA copy number after 5-minute irradiation.•TSID50 and not RT-qPCR should be used to m...

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Vydáno v:	American journal of infection control Ročník 49; číslo 3; s. 299 - 301
Hlavní autoři:	Kitagawa, Hiroki, Nomura, Toshihito, Nazmul, Tanuza, Omori, Keitaro, Shigemoto, Norifumi, Sakaguchi, Takemasa, Ohge, Hiroki
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 01.03.2021 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc
Témata:	COVID-19 COVID-19 - prevention & control COVID-19 - virology Decontamination - methods Disinfection Disinfection - methods Environmental contamination Far-UVC Humans Infectious Disease Major RNA, Viral - radiation effects SARS-CoV-2 - radiation effects Ultraviolet Rays COVID-19 Disinfection Environmental contamination Far-UVC
ISSN:	0196-6553, 1527-3296, 1527-3296
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Abstract	•222-nm UVC light (0.1 mW/cm2) reduced viable SARS-CoV-2 by 0.94 log10 in 10 seconds.•222-nm UVC light (0.1 mW/cm2) reduced viable SARS-CoV-2 by 2.51 log10 in 30 seconds.•222-nm UVC light did not reduce SARS-CoV-2 RNA copy number after 5-minute irradiation.•TSID50 and not RT-qPCR should be used to monitor far-UVC disinfection of surfaces. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has emerged as a serious threat to human health worldwide. Efficient disinfection of surfaces contaminated with SARS-CoV-2 may help prevent its spread. This study aimed to investigate the in vitro efficacy of 222-nm far-ultraviolet light (UVC) on the disinfection of SARS-CoV-2 surface contamination. We investigated the titer of SARS-CoV-2 after UV irradiation (0.1 mW/cm2) at 222 nm for 10-300 seconds using the 50% tissue culture infectious dose (TCID50). In addition, we used quantitative reverse transcription polymerase chain reaction to quantify SARS-CoV-2 RNA under the same conditions. One and 3 mJ/cm2 of 222-nm UVC irradiation (0.1 mW/cm2 for 10 and 30 seconds) resulted in 88.5 and 99.7% reduction of viable SARS-CoV-2 based on the TCID50 assay, respectively. In contrast, the copy number of SARS-CoV-2 RNA did not change after UVC irradiation even after a 5-minute irradiation. This study shows the efficacy of 222-nm UVC irradiation against SARS-CoV-2 contamination in an in vitro experiment. Further evaluation of the safety and efficacy of 222-nm UVC irradiation in reducing the contamination of real-world surfaces and the potential transmission of SARS-CoV-2 is needed.
AbstractList	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has emerged as a serious threat to human health worldwide. Efficient disinfection of surfaces contaminated with SARS-CoV-2 may help prevent its spread. This study aimed to investigate the in vitro efficacy of 222-nm far-ultraviolet light (UVC) on the disinfection of SARS-CoV-2 surface contamination. We investigated the titer of SARS-CoV-2 after UV irradiation (0.1 mW/cm ) at 222 nm for 10-300 seconds using the 50% tissue culture infectious dose (TCID ). In addition, we used quantitative reverse transcription polymerase chain reaction to quantify SARS-CoV-2 RNA under the same conditions. One and 3 mJ/cm of 222-nm UVC irradiation (0.1 mW/cm for 10 and 30 seconds) resulted in 88.5 and 99.7% reduction of viable SARS-CoV-2 based on the TCID assay, respectively. In contrast, the copy number of SARS-CoV-2 RNA did not change after UVC irradiation even after a 5-minute irradiation. This study shows the efficacy of 222-nm UVC irradiation against SARS-CoV-2 contamination in an in vitro experiment. Further evaluation of the safety and efficacy of 222-nm UVC irradiation in reducing the contamination of real-world surfaces and the potential transmission of SARS-CoV-2 is needed. Highlights•222-nm UVC light (0.1 mW/cm 2) reduced viable SARS-CoV-2 by 0.94 log10 in 10 seconds. •222-nm UVC light (0.1 mW/cm 2) reduced viable SARS-CoV-2 by 2.51 log10 in 30 seconds. •222-nm UVC light did not reduce SARS-CoV-2 RNA copy number after 5-minute irradiation. •TSID50 and not RT-qPCR should be used to monitor far-UVC disinfection of surfaces. •222-nm UVC light (0.1 mW/cm2) reduced viable SARS-CoV-2 by 0.94 log10 in 10 seconds.•222-nm UVC light (0.1 mW/cm2) reduced viable SARS-CoV-2 by 2.51 log10 in 30 seconds.•222-nm UVC light did not reduce SARS-CoV-2 RNA copy number after 5-minute irradiation.•TSID50 and not RT-qPCR should be used to monitor far-UVC disinfection of surfaces. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has emerged as a serious threat to human health worldwide. Efficient disinfection of surfaces contaminated with SARS-CoV-2 may help prevent its spread. This study aimed to investigate the in vitro efficacy of 222-nm far-ultraviolet light (UVC) on the disinfection of SARS-CoV-2 surface contamination. We investigated the titer of SARS-CoV-2 after UV irradiation (0.1 mW/cm2) at 222 nm for 10-300 seconds using the 50% tissue culture infectious dose (TCID50). In addition, we used quantitative reverse transcription polymerase chain reaction to quantify SARS-CoV-2 RNA under the same conditions. One and 3 mJ/cm2 of 222-nm UVC irradiation (0.1 mW/cm2 for 10 and 30 seconds) resulted in 88.5 and 99.7% reduction of viable SARS-CoV-2 based on the TCID50 assay, respectively. In contrast, the copy number of SARS-CoV-2 RNA did not change after UVC irradiation even after a 5-minute irradiation. This study shows the efficacy of 222-nm UVC irradiation against SARS-CoV-2 contamination in an in vitro experiment. Further evaluation of the safety and efficacy of 222-nm UVC irradiation in reducing the contamination of real-world surfaces and the potential transmission of SARS-CoV-2 is needed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has emerged as a serious threat to human health worldwide. Efficient disinfection of surfaces contaminated with SARS-CoV-2 may help prevent its spread. This study aimed to investigate the in vitro efficacy of 222-nm far-ultraviolet light (UVC) on the disinfection of SARS-CoV-2 surface contamination.BACKGROUNDSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has emerged as a serious threat to human health worldwide. Efficient disinfection of surfaces contaminated with SARS-CoV-2 may help prevent its spread. This study aimed to investigate the in vitro efficacy of 222-nm far-ultraviolet light (UVC) on the disinfection of SARS-CoV-2 surface contamination.We investigated the titer of SARS-CoV-2 after UV irradiation (0.1 mW/cm2) at 222 nm for 10-300 seconds using the 50% tissue culture infectious dose (TCID50). In addition, we used quantitative reverse transcription polymerase chain reaction to quantify SARS-CoV-2 RNA under the same conditions.METHODSWe investigated the titer of SARS-CoV-2 after UV irradiation (0.1 mW/cm2) at 222 nm for 10-300 seconds using the 50% tissue culture infectious dose (TCID50). In addition, we used quantitative reverse transcription polymerase chain reaction to quantify SARS-CoV-2 RNA under the same conditions.One and 3 mJ/cm2 of 222-nm UVC irradiation (0.1 mW/cm2 for 10 and 30 seconds) resulted in 88.5 and 99.7% reduction of viable SARS-CoV-2 based on the TCID50 assay, respectively. In contrast, the copy number of SARS-CoV-2 RNA did not change after UVC irradiation even after a 5-minute irradiation.RESULTSOne and 3 mJ/cm2 of 222-nm UVC irradiation (0.1 mW/cm2 for 10 and 30 seconds) resulted in 88.5 and 99.7% reduction of viable SARS-CoV-2 based on the TCID50 assay, respectively. In contrast, the copy number of SARS-CoV-2 RNA did not change after UVC irradiation even after a 5-minute irradiation.This study shows the efficacy of 222-nm UVC irradiation against SARS-CoV-2 contamination in an in vitro experiment. Further evaluation of the safety and efficacy of 222-nm UVC irradiation in reducing the contamination of real-world surfaces and the potential transmission of SARS-CoV-2 is needed.CONCLUSIONSThis study shows the efficacy of 222-nm UVC irradiation against SARS-CoV-2 contamination in an in vitro experiment. Further evaluation of the safety and efficacy of 222-nm UVC irradiation in reducing the contamination of real-world surfaces and the potential transmission of SARS-CoV-2 is needed.
Author	Omori, Keitaro Nazmul, Tanuza Shigemoto, Norifumi Kitagawa, Hiroki Sakaguchi, Takemasa Nomura, Toshihito Ohge, Hiroki
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32896604$$D View this record in MEDLINE/PubMed
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Copyright	2020 Association for Professionals in Infection Control and Epidemiology, Inc. Association for Professionals in Infection Control and Epidemiology, Inc. Copyright © 2020 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved. 2020 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. 2020 Association for Professionals in Infection Control and Epidemiology, Inc.
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Keywords	COVID-19 Disinfection Environmental contamination Far-UVC
Language	English
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Snippet	•222-nm UVC light (0.1 mW/cm2) reduced viable SARS-CoV-2 by 0.94 log10 in 10 seconds.•222-nm UVC light (0.1 mW/cm2) reduced viable SARS-CoV-2 by 2.51 log10 in... Highlights•222-nm UVC light (0.1 mW/cm 2) reduced viable SARS-CoV-2 by 0.94 log10 in 10 seconds. •222-nm UVC light (0.1 mW/cm 2) reduced viable SARS-CoV-2 by... Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has emerged as a serious threat to human health...
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SubjectTerms	COVID-19 COVID-19 - prevention & control COVID-19 - virology Decontamination - methods Disinfection Disinfection - methods Environmental contamination Far-UVC Humans Infectious Disease Major RNA, Viral - radiation effects SARS-CoV-2 - radiation effects Ultraviolet Rays
Title	Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination
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