Spatial patterns of brain lesions assessed through covariance estimations of lesional voxels in multiple Sclerosis: The SPACE-MS technique

[Display omitted] •We present SPACE-MS, a tool to assess the spatial distribution of brain lesions.•SPACE-MS metrics mainly reflect caudality and spatial spreading of brain lesions.•More caudal and more widespread brain lesions correlate with worse disability.•SPACE-MS metrics can be automatically o...

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Bibliographic Details
Published in:	NeuroImage clinical Vol. 33; p. 102904
Main Authors:	Tur, Carmen, Grussu, Francesco, De Angelis, Floriana, Prados, Ferran, Kanber, Baris, Calvi, Alberto, Eshaghi, Arman, Charalambous, Thalis, Cortese, Rosa, Chard, Declan T., Chataway, Jeremy, Thompson, Alan J., Ciccarelli, Olga, Gandini Wheeler-Kingshott, Claudia A.M.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01.01.2022 Elsevier
Subjects:	Anisotropy Brain - diagnostic imaging Brain - pathology Caudality Humans Lesion spatial distribution Magnetic resonance imaging Magnetic Resonance Imaging - methods Multiple sclerosis Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - pathology Multiple Sclerosis, Chronic Progressive - diagnostic imaging Multiple Sclerosis, Chronic Progressive - pathology Radiology Regular SPACE-MS White Matter - pathology Lesion spatial distribution Multiple sclerosis SPACE-MS Magnetic resonance imaging Caudality Anisotropy
ISSN:	2213-1582, 2213-1582
Online Access:	Get full text
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