Statin therapy reduces plasma endothelin-1 concentrations: A meta-analysis of 15 randomized controlled trials

Raised plasma endothelin-1 (ET-1) levels may be a risk factor for vascular dysfunction and cardiovascular (CV) disease. This meta-analysis assessed the effect of statins on circulating ET-1 concentrations. The search included PUBMED, Cochrane Library, Web of Science, Scopus, and EMBASE up to Septemb...

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Bibliographic Details
Published in:	Atherosclerosis Vol. 241; no. 2; pp. 433 - 442
Main Authors:	Sahebkar, Amirhossein, Kotani, Kazuhiko, Serban, Corina, Ursoniu, Sorin, Mikhailidis, Dimitri P., Jones, Steven R., Ray, Kausik K., Blaha, Michael J., Rysz, Jacek, Toth, Peter P., Muntner, Paul, Lip, Gregory Y.H., Banach, Maciej
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01.08.2015
Subjects:	Adult Aged Biomarkers - blood Cardiovascular Chi-Square Distribution Dyslipidemias - blood Dyslipidemias - diagnosis Dyslipidemias - drug therapy Endothelial dysfunction Endothelin-1 Endothelin-1 - blood Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Lipids - blood Lipophilicity Male Middle Aged Odds Ratio Randomized Controlled Trials as Topic Statins Therapy Treatment Outcome Endothelial dysfunction Therapy Lipophilicity Statins Endothelin-1
ISSN:	0021-9150, 1879-1484, 1879-1484
Online Access:	Get full text
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