Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology

[Display omitted] •Comparative study of whole-hemisphere ex vivo T2*-weighted MRI and histopathology.•Sample of FTLD-Tau and FTLD-TDP subtypes with reference to healthy and AD brain.•Novel focal upper cortical-layer iron-rich pathology distinguishes FTLD-TDP from clinically-similar FTLD-Tau and AD.•...

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Bibliographic Details
Published in:	NeuroImage clinical Vol. 33; p. 102913
Main Authors:	Tisdall, M. Dylan, Ohm, Daniel T., Lobrovich, Rebecca, Das, Sandhitsu R., Mizsei, Gabor, Prabhakaran, Karthik, Ittyerah, Ranjit, Lim, Sydney, McMillan, Corey T., Wolk, David A., Gee, James, Trojanowski, John Q., Lee, Edward B., Detre, John A., Yushkevich, Paul, Grossman, Murray, Irwin, David J.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01.01.2022 Elsevier
Subjects:	Alzheimer’s disease DNA-Binding Proteins Ex vivo MRI Frontotemporal Dementia - diagnostic imaging Frontotemporal Dementia - pathology Frontotemporal lobar degeneration Frontotemporal Lobar Degeneration - diagnostic imaging Frontotemporal Lobar Degeneration - pathology Histopathology Humans Inflammation - diagnostic imaging Iron Magnetic Resonance Imaging Radiology Regular tau Proteins Frontotemporal lobar degeneration Ex vivo MRI Iron Histopathology Alzheimer’s disease
ISSN:	2213-1582, 2213-1582
Online Access:	Get full text
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