Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone

In addition to the serotonin 5-HT 2A receptor (5-HT 2A R), the dopamine D 2 receptor (D 2 R) is a key therapeutic target of antipsychotics for the treatment of schizophrenia. The inactive state structures of D 2 R have been described in complex with the inverse agonists risperidone (D 2 R ris ) and...

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Veröffentlicht in:	Nature communications Jg. 11; H. 1; S. 6442 - 11
Hauptverfasser:	Im, Dohyun, Inoue, Asuka, Fujiwara, Takaaki, Nakane, Takanori, Yamanaka, Yasuaki, Uemura, Tomoko, Mori, Chihiro, Shiimura, Yuki, Kimura, Kanako Terakado, Asada, Hidetsugu, Nomura, Norimichi, Tanaka, Tomoyuki, Yamashita, Ayumi, Nango, Eriko, Tono, Kensuke, Kadji, Francois Marie Ngako, Aoki, Junken, Iwata, So, Shimamura, Tatsuro
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 22.12.2020 Nature Publishing Group Nature Portfolio
Schlagworte:	101/1 631/45/612/194 631/535 631/535/1266 82/80 82/83 Antipsychotics Binding Conformation Crystal structure Dopamine Dopamine D2 receptors G protein-coupled receptors Haloperidol Humanities and Social Sciences Inverse agonists Mental disorders multidisciplinary Psychotropic drugs Receptors Risperidone Schizophrenia Science Science (multidisciplinary) Selectivity Serotonin Serotonin S2 receptors Spiperone Therapeutic targets
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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