Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases

Key Points TNF inhibitors are among the most effective protein-based drugs for reducing inflammation associated with several rheumatic diseases In addition to TNF, the TNF superfamily (TNFSF) comprises other ligand–receptor combinations that might participate in the pathogenesis of rheumatic disease...

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Bibliographic Details
Published in:	Nature reviews. Rheumatology Vol. 13; no. 4; pp. 217 - 233
Main Authors:	Croft, Michael, Siegel, Richard M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.04.2017 Nature Publishing Group
Subjects:	4-1BB Ligand - antagonists & inhibitors 4-1BB Ligand - metabolism 692/4023/1670 692/420/256 692/420/2780 692/700/565/1436 Animals Antigens Arthritis Care and treatment CD27 Ligand - antagonists & inhibitors CD27 Ligand - metabolism CD40 Ligand - antagonists & inhibitors CD40 Ligand - metabolism Cell Death Cytokine TWEAK Cytokines Dendritic cells Dendritic Cells - immunology Development and progression Fas Ligand Protein - antagonists & inhibitors Fas Ligand Protein - metabolism Genetic aspects Growth factors Health aspects Humans Immune system Immune Tolerance Ligands Lupus Lymphocyte Activation Lymphotoxin-alpha - antagonists & inhibitors Lymphotoxin-alpha - metabolism Medicine & Public Health Molecular Targeted Therapy OX40 Ligand - antagonists & inhibitors OX40 Ligand - metabolism Proteins review-article Rheumatic diseases Rheumatic Diseases - drug therapy Rheumatic Diseases - immunology Rheumatology Signal Transduction T-Lymphocytes - immunology TNF-Related Apoptosis-Inducing Ligand - antagonists & inhibitors TNF-Related Apoptosis-Inducing Ligand - metabolism Tumor necrosis factor Tumor Necrosis Factor Ligand Superfamily Member 14 - antagonists & inhibitors Tumor Necrosis Factor Ligand Superfamily Member 14 - metabolism Tumor Necrosis Factor Ligand Superfamily Member 15 - antagonists & inhibitors Tumor Necrosis Factor Ligand Superfamily Member 15 - metabolism Tumor Necrosis Factors - antagonists & inhibitors Tumor Necrosis Factors - immunology Tumor Necrosis Factors - metabolism La Jolla California United States > US
ISSN:	1759-4790, 1759-4804
Online Access:	Get full text
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