Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site

Antibodies that neutralize autologous transmitted/founder (TF) HIV occur in most HIV-infected individuals and can evolve to neutralization breadth. Autologous neutralizing antibodies (nAbs) against neutralization-resistant (Tier-2) viruses are rarely induced by vaccination. Whereas broadly neutraliz...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 14; no. 1; pp. 43 - 54
Main Authors:	Bradley, Todd, Fera, Daniela, Bhiman, Jinal, Eslamizar, Leila, Lu, Xiaozhi, Anasti, Kara, Zhang, Ruijung, Sutherland, Laura L., Scearce, Richard M., Bowman, Cindy M., Stolarchuk, Christina, Lloyd, Krissey E., Parks, Robert, Eaton, Amanda, Foulger, Andrew, Nie, Xiaoyan, Karim, Salim S. Abdool, Barnett, Susan, Kelsoe, Garnett, Kepler, Thomas B., Alam, S. Munir, Montefiori, David C., Moody, M. Anthony, Liao, Hua-Xin, Morris, Lynn, Santra, Sampa, Harrison, Stephen C., Haynes, Barton F.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 05.01.2016 Elsevier
Subjects:	AIDS Vaccines - immunology AIDS Vaccines - pharmacology Amino Acid Sequence Animals Antibodies, Neutralizing - immunology BASIC BIOLOGICAL SCIENCES env Gene Products, Human Immunodeficiency Virus - genetics env Gene Products, Human Immunodeficiency Virus - immunology Female HIV Antibodies - immunology HIV-1 - genetics HIV-1 - immunology Humans Macaca mulatta Male Molecular Sequence Data
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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