Molecular evolution and functional characterization of the orexigenic peptide 26RFa and its receptor in vertebrates

Several neuropeptides possessing the RFamide motif at their C-termini (designated RFamide peptides) have been characterized in the hypothalamus of a variety of vertebrates. To date, five groups of the RFamide peptide family have been shown to exert several important neuroendocrine, behavioral, senso...

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Bibliographic Details
Published in:Cell and tissue research Vol. 343; no. 3; pp. 475 - 481
Main Authors: Ukena, Kazuyoshi, Vaudry, Hubert, Leprince, Jérôme, Tsutsui, Kazuyoshi
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer-Verlag 01.03.2011
Springer
Springer Nature B.V
Springer Verlag
Subjects:
Amino Acid Sequence
Animals
Biomedical and Life Sciences
Biomedicine
birds
Cell Behavior
Cellular Biology
Chemical properties
Chemical Sciences
classification
evolution
Evolution, Molecular
Evolutionary biology
frogs
genetics
Human Genetics
Humans
hypothalamus
Life Sciences
mammals
Medicinal Chemistry
metabolism
Mini Review
Molecular biology
Molecular Medicine
Molecular Sequence Data
Neurobiology
Neurons and Cognition
Neuropeptides
Neuropeptides - classification
Neuropeptides - genetics
Neuropeptides - metabolism
Peptides
Pharmaceutical sciences
Pharmacology
Phylogeny
Proteomics
Receptors, Neuropeptide
Receptors, Neuropeptide - genetics
Receptors, Neuropeptide - metabolism
Sequence Alignment
Vertebrates
Vertebrates - genetics
Vertebrates - metabolism
Vertebrates
26RFa
Hypothalamus
Food intake
Neuropeptide
G-protein-coupled receptor
ISSN:0302-766X, 1432-0878, 1432-0878
Online Access:Get full text
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Summary:Several neuropeptides possessing the RFamide motif at their C-termini (designated RFamide peptides) have been characterized in the hypothalamus of a variety of vertebrates. To date, five groups of the RFamide peptide family have been shown to exert several important neuroendocrine, behavioral, sensory, and autonomic functions. Since the discovery of the 26-amino acid RFamide peptide (termed 26RFa) from the frog brain, 26RFa has been shown to exert orexigenic activity in mammals and to be a ligand of the previously identified orphan G-protein-coupled receptor GPR103. Recently, 26RFa and its cognate receptor GPR103 have been identified in the brain of birds. This mini-review summarizes the advances in the identification, localization, and functions of 26RFa and its cognate receptor GPR103 in vertebrates and highlights recent progress made in birds.
Bibliography:http://dx.doi.org/10.1007/s00441-010-1116-z
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ISSN:0302-766X
1432-0878
1432-0878
DOI:10.1007/s00441-010-1116-z