Molecular evolution and functional characterization of the orexigenic peptide 26RFa and its receptor in vertebrates

Several neuropeptides possessing the RFamide motif at their C-termini (designated RFamide peptides) have been characterized in the hypothalamus of a variety of vertebrates. To date, five groups of the RFamide peptide family have been shown to exert several important neuroendocrine, behavioral, senso...

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Vydáno v:	Cell and tissue research Ročník 343; číslo 3; s. 475 - 481
Hlavní autoři:	Ukena, Kazuyoshi, Vaudry, Hubert, Leprince, Jérôme, Tsutsui, Kazuyoshi
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer-Verlag 01.03.2011 Springer Springer Nature B.V Springer Verlag
Témata:	Amino Acid Sequence Animals Biomedical and Life Sciences Biomedicine birds Cell Behavior Cellular Biology Chemical properties Chemical Sciences classification evolution Evolution, Molecular Evolutionary biology frogs genetics Human Genetics Humans hypothalamus Life Sciences mammals Medicinal Chemistry metabolism Mini Review Molecular biology Molecular Medicine Molecular Sequence Data Neurobiology Neurons and Cognition Neuropeptides Neuropeptides - classification Neuropeptides - genetics Neuropeptides - metabolism Peptides Pharmaceutical sciences Pharmacology Phylogeny Proteomics Receptors, Neuropeptide Receptors, Neuropeptide - genetics Receptors, Neuropeptide - metabolism Sequence Alignment Vertebrates Vertebrates - genetics Vertebrates - metabolism Vertebrates 26RFa Hypothalamus Food intake Neuropeptide G-protein-coupled receptor
ISSN:	0302-766X, 1432-0878, 1432-0878
On-line přístup:	Získat plný text
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Shrnutí:	Several neuropeptides possessing the RFamide motif at their C-termini (designated RFamide peptides) have been characterized in the hypothalamus of a variety of vertebrates. To date, five groups of the RFamide peptide family have been shown to exert several important neuroendocrine, behavioral, sensory, and autonomic functions. Since the discovery of the 26-amino acid RFamide peptide (termed 26RFa) from the frog brain, 26RFa has been shown to exert orexigenic activity in mammals and to be a ligand of the previously identified orphan G-protein-coupled receptor GPR103. Recently, 26RFa and its cognate receptor GPR103 have been identified in the brain of birds. This mini-review summarizes the advances in the identification, localization, and functions of 26RFa and its cognate receptor GPR103 in vertebrates and highlights recent progress made in birds.
Bibliografie:	http://dx.doi.org/10.1007/s00441-010-1116-z ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Review-3
ISSN:	0302-766X 1432-0878 1432-0878
DOI:	10.1007/s00441-010-1116-z