Platelet Rich Plasma and Hyaluronic Acid Blend for the Treatment of Osteoarthritis: Rheological and Biological Evaluation

Osteoarthritis (OA) is the most common musculoskeletal disease. Current treatments for OA are mainly symptomatic and inadequate since none results in restoration of fully functional cartilage. Hyaluronic Acid (HA) intra-articular injections are widely accepted for the treatment of pain associated to...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 6; p. e0157048
Main Authors:	Russo, Fabrizio, D’Este, Matteo, Vadalà, Gianluca, Cattani, Caterina, Papalia, Rocco, Alini, Mauro, Denaro, Vincenzo
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 16.06.2016 Public Library of Science (PLoS)
Subjects:	Acids Aged Arthritis Biocompatibility Biological effects Biological properties Biology and Life Sciences Biomedical materials Blood & organ donations Blood platelets Bovine serum albumin Cartilage Cartilage - drug effects Cartilage diseases Cell culture Cell Proliferation - drug effects Cell Survival - drug effects Chondrocytes Chondrocytes - drug effects Culture media Defects Dilution Disease Extracellular matrix Fluids Formulations Glycosaminoglycans - metabolism Growth factors Humans Hyaluronic acid Hyaluronic Acid - administration & dosage Hyaluronic Acid - metabolism Inflammation Injections, Intra-Articular Joint surgery Knee Medical treatment Medicine and Health Sciences Middle Aged Mixtures Musculoskeletal diseases Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - metabolism Osteoarthritis - pathology Pain Pain - drug therapy Pain - pathology Physical Sciences Plasma Platelet-Rich Plasma - chemistry Platelets Primary Cell Culture Proteins Quality of life Regeneration Restoration Rheological properties Rheology Serum albumin Shear modulus Surgery Synovial fluid Synovial Fluid - metabolism Viscoelasticity Viscosity - drug effects Wound healing Italy Switzerland
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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