The CDT of Helicobacter hepaticus induces pro-survival autophagy and nucleoplasmic reticulum formation concentrating the RNA binding proteins UNR/CSDE1 and P62/SQSTM1

Humans are frequently exposed to bacterial genotoxins of the gut microbiota, such as colibactin and cytolethal distending toxin (CDT). In the present study, whole genome microarray-based identification of differentially expressed genes was performed in vitro on HT29 intestinal cells while following...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 17; no. 3; p. e1009320
Main Authors:	He, Wencan, Azzi-Martin, Lamia, Velasco, Valérie, Lehours, Philippe, Dubus, Pierre, Djavaheri-Mergny, Mojgan, Ménard, Armelle
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 04.03.2021 Public Library of Science (PLoS)
Subjects:	Abbreviations Analysis Apoptosis Aspartic acid Autophagy Autophagy (Cytology) Binding Binding proteins Biology and Life Sciences Biosynthesis Calcium Cancer Catalytic activity Cell cycle Cell death Cell survival Chains Cholesterol Coils Damage Deoxyribonucleic acid DNA DNA damage DNA microarrays DNA repair Domains E coli Ectopic expression Fluorescence Forkhead protein FOXO1 protein Gene expression Genes Genetic aspects Genomes Grb2 protein Growth factors Helicobacter Helicobacter infections Homology Hypoxia Initiation factor eIF-2 Inositol 1,4,5-trisphosphate receptors Insulation Intestine Intoxication Kinases Life Sciences Medicine and Health Sciences Membrane proteins Membranes Phagocytosis Polyploidy Protein-serine/threonine kinase Proteins Rapamycin Receptors Research and analysis methods Retina Retinoblastoma RNA RNA-binding protein Survival Transcription Ubiquitin-protein ligase Zinc finger proteins γ-Aminobutyric acid France
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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