Combination of NK Cells and Cetuximab to Enhance Anti-Tumor Responses in RAS Mutant Metastatic Colorectal Cancer

The ability of Natural Killer (NK) cells to kill tumor targets has been extensively studied in various hematological malignancies. However, NK cell therapy directed against solid tumors is still in early development. Epidermal Growth Factor Receptor (EGFR) targeted therapies using monoclonal antibod...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 6; p. e0157830
Main Authors:	Veluchamy, John Pradeep, Spanholtz, Jan, Tordoir, Marleen, Thijssen, Victor L., Heideman, Daniëlle A. M., Verheul, Henk M. W., de Gruijl, Tanja D., van der Vliet, Hans J.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 17.06.2016 Public Library of Science (PLoS)
Subjects:	Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - immunology Biology and life sciences Biotechnology Caco-2 Cells Cancer CD16 antigen Cell division Cell Proliferation - drug effects Cell- and Tissue-Based Therapy Cetuximab - administration & dosage Colon Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - immunology Colorectal Neoplasms - pathology Cytotoxicity Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics Fc receptors Hematology HT29 Cells Humans Immunoglobulin G Immunoglobulin G - immunology Immunoglobulins Immunotherapy Killer Cells, Natural Medical prognosis Medicine and health sciences Metastases Metastasis Monoclonal antibodies Mutation Natural killer cells Neoplasm Metastasis Oncology Peripheral blood Proto-Oncogene Proteins B-raf - genetics Ras protein ras Proteins - genetics Receptors Research and analysis methods Solid tumors Targeted cancer therapy Therapy Toxicity Tumor cell lines Tumor cells Tumors Netherlands
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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