Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

Interactions between B and T cells are essential for most antibody responses, but the dynamics of these interactions are poorly understood. By two-photon microscopy of intact lymph nodes, we show that upon exposure to antigen, B cells migrate with directional preference toward the B-zone-T-zone boun...

Full description

Saved in:

Bibliographic Details
Published in:	PLoS biology Vol. 3; no. 6; p. e150
Main Authors:	Okada, Takaharu, Miller, Mark J, Parker, Ian, Krummel, Matthew F, Neighbors, Margaret, Hartley, Suzanne B, O'Garra, Anne, Cahalan, Michael D, Cyster, Jason G
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.06.2005 Public Library of Science (PLoS)
Subjects:	B-Lymphocytes - immunology Cell Communication - immunology Chemotaxis, Leukocyte - immunology Humans Immune system Immunology Lymph nodes Lymphocytes Mus (Mouse) Ovalbumin - immunology Proteins Receptors, CCR7 Receptors, Chemokine - immunology T cell receptors T-Lymphocytes, Helper-Inducer - immunology Chemotaxis, Leukocyte Ovalbumin Humans Receptors, CCR7 B-Lymphocytes Cell Communication T-Lymphocytes, Helper-Inducer Receptors, Chemokine
ISSN:	1545-7885, 1544-9173, 1545-7885
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!