Restriction of multiple divergent retroviruses by Lv1 and Ref1

The mouse gene Fv1 encodes a saturable restriction factor that selectively blocks infection by N‐tropic or B‐tropic murine leukemia virus (MLV) strains. Despite the absence of an Fv1 gene, a similar activity is present in humans that blocks N‐MLV infection (Ref1). Moreover, some non‐human primate ce...

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Veröffentlicht in:	The EMBO journal Jg. 22; H. 3; S. 385 - 394
Hauptverfasser:	Hatziioannou, Theodora, Cowan, Simone, Goff, Stephen P., Bieniasz, Paul D., Towers, Greg J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Chichester, UK John Wiley & Sons, Ltd 03.02.2003 Nature Publishing Group UK Springer Nature B.V Oxford University Press
Schlagworte:	Animals Carbon-Oxygen Lyases - metabolism Cell Line Chlorocebus aethiops DNA, Viral DNA-(Apurinic or Apyrimidinic Site) Lyase EMBO23 HIV HIV-1 - metabolism Humans Leukemia Leukemia Virus, Murine - metabolism Lv1 Mice MLV Polymorphism, Genetic Proteins - genetics Proteins - metabolism Recombinant Fusion Proteins - metabolism Ref1 restriction Retroviridae - physiology Simian Immunodeficiency Virus - metabolism Ref1 restriction HIV Lv1 MLV
ISSN:	0261-4189, 1460-2075, 1460-2075
Online-Zugang:	Volltext
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Zusammenfassung:	The mouse gene Fv1 encodes a saturable restriction factor that selectively blocks infection by N‐tropic or B‐tropic murine leukemia virus (MLV) strains. Despite the absence of an Fv1 gene, a similar activity is present in humans that blocks N‐MLV infection (Ref1). Moreover, some non‐human primate cell lines express a potentially related inhibitor of HIV‐1 and/or SIVmac infection (Lv1). Here, we examine the spectrum of retrovirus‐restricting activities expressed by human and African green monkey cell lines. Human cells restrict N‐MLV and equine infectious anemia virus (EIAV), but not HIV‐1, HIV‐2, SIVmac or SIVagm, whilst AGM cells restrict N‐MLV, EIAV, HIV‐1, HIV‐2 and SIVmac. Remarkably, in each example examined, restriction of infection by a given retrovirus can be abrogated at least partially by saturation with another retrovirus, provided that it is also restricted but regardless of whether it is closely related. These data suggest that restriction factors in human and non‐human primate cells are able to recognize and block infection by multiple, widely divergent retroviruses and that the factors themselves may be related.
Bibliographie:	istex:BC48AD6E710443E3BC38E03FC864278A89FE5CC0 ArticleID:EMBJ7594953 ark:/67375/WNG-TZRMSMJ0-0 Supplementary data ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23
ISSN:	0261-4189 1460-2075 1460-2075
DOI:	10.1093/emboj/cdg042