Structures of protective antibodies reveal sites of vulnerability on Ebola virus

Ebola virus (EBOV) and related filoviruses cause severe hemorrhagic fever, with up to 90% lethality, and no treatments are approved for human use. Multiple recent outbreaks of EBOV and the likelihood of future human exposure highlight the need for pre- and postexposure treatments. Monoclonal antibod...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 111; H. 48; S. 17182
Hauptverfasser:	Murin, Charles D, Fusco, Marnie L, Bornholdt, Zachary A, Qiu, Xiangguo, Olinger, Gene G, Zeitlin, Larry, Kobinger, Gary P, Ward, Andrew B, Saphire, Erica Ollmann
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 02.12.2014
Schlagworte:	Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Viral - chemistry Antibodies, Viral - immunology Antibody Affinity - immunology Antibody Specificity - immunology Binding Sites, Antibody - immunology Cell Line Ebolavirus - immunology Ebolavirus - metabolism Epitopes - chemistry Epitopes - immunology Glycoproteins - immunology Hemorrhagic Fever, Ebola - immunology Hemorrhagic Fever, Ebola - virology Immunoglobulin Fab Fragments - immunology Microscopy, Electron Models, Molecular Protein Structure, Tertiary Viral Proteins - immunology EM antibodies Ebola ZMapp
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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